Discover and read the best of Twitter Threads about #Pleiotropy

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✨✨We are thrilled to share 2 new papers published this week in:
#BiologicalPsychiatry: Genetic heterogeneity shapes brain connectivity in psychiatry
dx.doi.org/10.1016/j.biop…

#Brain: Brain connectivity mirrors genetic pleiotropy in psychiatric conditions academic.oup.com/brain/advance-…
1/7 #Polygenicity (=multiple genetic variants associated with one condition) and #pleiotropy (=one genetic variant influencing more than one trait) are key properties of the genomic architecture of #psychiatric conditions and represent major challenges in identifying mechanisms.
2/7 We processed 9 rs-fMRI datasets including 32,726 individuals, to examine the connectome-wide effects of 15 copy number variants, 7 polygenic scores (common variants), and 4 idiopathic psychiatric conditions (Autism, Schizophrenia, ADHD, Bipolar disorder).
Read 8 tweets
Excited to see my first ever first-author paper and the first chapter of my dissertation out now in @ISMEJournal!

We did an exhaustive review/synthesis of what is known about the effects of community context on bacteria-phage ecology and evolution (spoiler: not much)

A🧵(1/n)
If you want a little more detail than a Twitter thread, you can check out a 'behind-the-paper' blog post we wrote here: naturemicrobiologycommunity.nature.com/posts/in-bacte…

(2/n)
There has been a long history of studying bacteria and their viral symbionts, #bacteriophages. In #ecology and #evolution, they've been workhorse systems for studying host-parasite interactions for many years (3/n)
Read 15 tweets
1/ 💥Hello, #Nephtwitter 💥
⚡️Let’s talk a little bit about #ciliopathies today.
⚡️How are Nephronophthisis (NPHP), polycystic kidney disease (PKD), & in fact many cystic diseases (aka #ciliopathies) related?!
Join me in the exploration-
#tweetorial #MedTwitter #ASPNeph #NSMC
2/ 💥Let’s begin with Cilia-
📌Motile cilia- generate flow of mucus & CSF
📌Non-motile/sensory cilia (inner ear, retina, & olfactory epithelium)
- plays a part in important pathways [Hedgehog, Wnt (wingless-Int-1), & PCP (planar cell polarity) signaling]
ncbi.nlm.nih.gov/pmc/articles/P…
3/Now let’s move on to💥Cystoproteins💥
📌These are proteins in cilia when mutated → cystic kidney diseases in humans, mice, or zebrafish
📌expressed in primary cilia, basal bodies or centrosomes
Read 9 tweets

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