Discover and read the best of Twitter Threads about #Polygenicity
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✨✨We are thrilled to share 2 new papers published this week in:
#BiologicalPsychiatry: Genetic heterogeneity shapes brain connectivity in psychiatry
dx.doi.org/10.1016/j.biop…
#Brain: Brain connectivity mirrors genetic pleiotropy in psychiatric conditions academic.oup.com/brain/advance-…
#BiologicalPsychiatry: Genetic heterogeneity shapes brain connectivity in psychiatry
dx.doi.org/10.1016/j.biop…
#Brain: Brain connectivity mirrors genetic pleiotropy in psychiatric conditions academic.oup.com/brain/advance-…
1/7 #Polygenicity (=multiple genetic variants associated with one condition) and #pleiotropy (=one genetic variant influencing more than one trait) are key properties of the genomic architecture of #psychiatric conditions and represent major challenges in identifying mechanisms.
2/7 We processed 9 rs-fMRI datasets including 32,726 individuals, to examine the connectome-wide effects of 15 copy number variants, 7 polygenic scores (common variants), and 4 idiopathic psychiatric conditions (Autism, Schizophrenia, ADHD, Bipolar disorder).
