Discover and read the best of Twitter Threads about #Pregnancy

Most recents (24)

Most of the very extensive data showing that #CovidVaccines are safe and effective in #pregnancy was collected in the general rollout.

Is this okay? Shouldn’t we have trial data?

Let’s talk about the ethics of vaccine trials in pregnancy! 🧵…

drive.google.com/file/d/1_wHIYX…
First, let’s note that we do have some data on pregnancy from the COVID vaccine trials. Participants were asked not to become pregnant, but some did by accident. The outcomes for these pregnancies were monitored as part of the trials, with no concerns emerging. 2/
Because…

1. What little data we had was reassuring

2. What we know of 💉 biology suggested there would not be any problems in 🤰🏻

3. COVID 🦠 *does* cause problems in pregnancy

… some countries 🇺🇸 🇮🇱 opted to offer the 💉 and let 🤰🏻 decide

3/
Read 14 tweets
If you are #pregnant, the #CovidVaccine is strongly recommended and you will soon be offered a booster. #BoostTheBump

The recommendation is made on the basis of extensive data that the vaccine is safe and effective, by the following bodies… 1/

drive.google.com/file/d/1_wHIYX…
The UK government… 2/

gov.uk/government/pub…
Read 8 tweets
If you are #pregnant in the UK, the @NHSuk strongly recommends that you get the #CovidVaccine if you are not already protected.

The advice has not changed!

So why are some people saying that it has? 🤔

🧵...

nhs.uk/conditions/cor…
In December 2020, Pfizer submitted data on its vaccine to the MHRA for temporary approval, which was granted. The documents on this are in the public domain... 2/

gov.uk/government/pub…
Periodically, Pfizer sends the MHRA some more data. On 16 August, they sent some additional data on boosting with different brands of vaccine. The documents were updated accordingly. 3/

gov.uk/government/pub…
Read 9 tweets
85,162 ppl giving birth in 🇨🇦May - Dec ‘21, of whom 43,099 had a #CovidVaccine during #pregnancy.

👉🏻 No increased risk of stillbirth, preterm birth or being born smaller than expected following vaccination.

1/

bmj.com/content/bmj/37…
In fact, the authors found a slight reduction in the risk of stillbirth and very preterm birth among those vaccinated. Although they controlled for known confounders, they didn’t feel confident that this wasn’t due to residual confounding. 2/
However, it is in line with the findings from other large studies which show a reduced risk of stillbirth following vaccination… 3/

nature.com/articles/s4146…
Read 4 tweets
For those interested in the miscarriage rate among those who became pregnant during the trial of the Pfizer #CovidVaccine….

👉🏻 Vaccine group 7%

👉🏻 Control group 15%

👉🏻 These rates are not significantly different from each other, or from normal

1/

fda.gov/media/152256/d…
These data were published about a year ago, but ppl are talking about it today because Naomi Wolf has looked at the FOI data and claims she has found a miscarriage rate of 44%. Unclear how she has done this but seems to be a combination of… 2/
👉🏻 Accidentally counting everything twice (oops)

👉🏻 Counting some ppl who didn’t have miscarriages (eg. males)

👉🏻 Counting miscarriages among the control group (ie. ppl who did not get vaccinated). 3/3
Read 4 tweets
How long is #COVID19 infectious? #COVID19infectionpersistence Those with SARS-CoV-2 are often advised to isolate for only a few days. But evidence is mounting that some people can continue to pass on the virus for much longer. nature.com/articles/d4158…
Read 16 tweets
De retour dans l’univers des IA qui génèrent des images, je teste “Midjourney” (en open beta)

Je suis impressionné par l’IA et par l’UI, c’est sous la forme d’un bot Discord 😮
« Goku en train de manger des spaghetti »
#AIart #Midjourney #DragonBall Image
Quelqu’un a demandé “true love” et a obtenu ça 😮

Presque toutes les variations et agrandissements on été demandés 😀
#AIart #love Image
Read 60 tweets
New preprint looking at 32,536 ppl giving birth in Melbourne 🇦🇺of whom 17,356 received a #CovidVaccine in #pregnancy

👉🏻 Congenital abnormalities, preterm birth and stillbirth all significantly *lower* in the vaccinated group.

medrxiv.org/content/10.110…
🤓 Section

Though this is in line with what we expect, I was surprised to see such clear results in a single study - albeit a big one. Is there a bias here?

In this cohort the vaccinated are generally healthier and wealthier, but the authors adjust for this. 2/
They also restrict the sample to ppl for whom weeks 20-43 following LMP fall entirely within the study period, to avoid fixed cohort bias. 3/
Read 8 tweets
A) a fetus dies inside of the uterus, but fails to evacuate. The mother becomes septic. She is given an Dialation & Curettage

B) A woman chooses to end her #pregnancy She is given a Dialation & Curettage

Are these both #ABORTIONS ?

#RoeVsWade #AbortionBan
C) in the first trimester a woman has a partial placental abruption, the fetus is failing to thrive, miscarriage is nearly inevitable. She has a D&C

D) a woman decides to end her pregnancy. She has a D&C

Are both abortions?
E) a woman is diagnosed with cancer. The treatment will slowly terminate her pregnancy, and could cause serious complications. No treatment = death. She has a D&C

F) a woman decides to end her pregnancy. She has a D&C
Read 14 tweets
Hot but not bothered?🧠🔥 Our paper on human brain temperature is out today in Brain! @ONeill_Lab @MRC_LMB @Brain1878 #LMBResearch #BrainTemp #BrainTrauma doi.org/10.1093/brain/…
With thanks to our amazing participants, collaborators, and supporters @AriErcole @Etherjoe @ManuelCabeleira @CescaStats @EdinUniImaging @EdinUniNeuro @EdinUniBrainSci @CenterTBI @CellBiol_MRCLMB @RachelSEdgar and @The_MRC for funding
In a prospective analysis of healthy men and women, we found that brain temperature is higher than body temperature; brain temperature ranges from 36.1 to 40.9°C, with an average of 38.5C 🧠🔥.
Read 11 tweets
🧵 Question Abt: Transplantation and Fetal Toxicity of Immunosuppressive Drugs in Pregnancy. 1/13 #Access #ProLife #prochoice #SCT #AbortionBan #healthcare
Q: What is the medical safety net for premenopausal women that are also transplant recipients who MUST take multiple immunosuppressive drugs? 2/13

#Access #ProLife #prochoice #SCT #AbortionBan #healthcare
She can’t depend on the #pill to prevent an unwanted #pregnancy because of daily antibiotics. 3/13

#Access #ProLife #prochoice #SCT #AbortionBan #healthcare
Read 14 tweets
#SCOTUS news are shocking
Even tho no big surprise: This lets the dreams of far-right movements from Poland via France to Brazil come true: to repressively control the female body, thus her reproduction, thus her sex life
I take 1 personal and 2 political points out of this 1/4
As a (hopefully) loving boyfriend, the most terrible moments for gf's were when there was the slightest hint of a potential (!) #pregnancy. To disregard the, (as I'd say as a bystander) emotional horror women go through, is appalling. Women need #support, not #oppression!
Politically (also in #Europe), the far-right has succeeded by playing dirty: Disregarding all democratic traditions and fair play rules for electing #SCOTUS judges, this is a key example of how "just setting an example" is not enough.
No: Key institutions require tough fights!
Read 6 tweets
NEW PAPER ALERT📢
A favorite paper of my career! ➡️ rb.gy/1scuc5 Mothers who participated in a prenatal #mindfulness intervention had babies with healthier #stress responses, suggesting psychosocial #pregnancy #intervention can positively shape infant #health! 🧵 1/ Image
Check out the @UCSF web story on the paper here, written by the wonderful @BertholdJess: 2/ ucsf.edu/news/2022/03/4…
BACKGROUND
This study followed prior work by @Dr_Epel, me & team, which showed the #prenatal #intervention: reduced women’s stress & depression, increased physical activity, lowered diabetes risk. Here, we tested whether these health benefits extended to the developing child. 3/ Image
Read 11 tweets
#Mixtures matter! Check out our new study in @ScienceMagazine where we show the impact of real-life chemical exposure during pregnancy on language development, integrating epidemiology and experimental neurobiology (1/14) science.org/doi/10.1126/sc…
on the same issue, do not miss also the insightful perspective by @liew_zeyan and Pengfei Guo (2/10) science.org/doi/10.1126/sc… (2/14)
and here an animated summary of the story () by @secret_molecule (3/14)
Read 14 tweets
Update.

Deaths WITH #Covid19 age 0-19 yrs as of Jan 21 2022:

27

Reported/accepted #vaccine adverse events age 5-17 yrs (#Pfizer Comirnaty authorized Nov 19, 2021) as of Jan 14 2022 (56 days)

1,288

(w/ 291 categorized as serious in 12-17 yr old group)
#RegulatoryCapture

Prior to intro. of user fees in 1994, #HealthCanada was solely funded by tax dollars - therefore accountable to the public. By 2018, approx. 50% of #HealthCanada’s budget came from #Pharma. Quietly announced in Oct 2017 was intention to increase to 90%.
On May 27, 2021, Dr. Patrick Phillips was asked if the data in Canada's adverse event system can be trusted. He replied "absolutely not" & suggested #VAERS may be more reliable. However, "HHS’s own studies indicate that VAERS may be understating vaccine injuries by OVER 99%."
Read 12 tweets
2,126 couples #TryingToConceive between Dec 2020 and Sep 2021…

👩‍❤️‍👨💉 #CovidVaccination made no difference to per cycle chance of #pregnancy

👩🏻🦠 Infection of female partners made no difference…

👦🏽🦠… but in males ⬇️ chance of pregnancy for ~60d.

academic.oup.com/aje/advance-ar…
The finding that #CovidVaccination does not affect #fertility mirrors what we have already seen in IVF settings, but it is good (if unsurprising!) to see it confirmed among those #TryingToConceive the old fashioned way! 2/

drive.google.com/file/d/1_wHIYX…
This is the first study to look at the effects of #Covid infection on #fertility.

It’s reassuring to see that it doesn’t affect chance of conception in female partners. 3/
Read 6 tweets
New findings on #CovidVaccination and #Fertility!

Using the @BUPRESTOStudy, we show no association between #CovidVaccination in either partner and fertility among couples #TryingToConceive

A 🧵 on our new study in @AmJEpi #EpiTwitter (1/12)
doi.org/10.1093/aje/kw…
We enrolled couples who were #TryingToConceive without fertility treatment. Female and male partners completed questionnaires on lifestyle, health, and #covid19 infection and vaccination. We followed couples for up to 12 months to determine whether and when they conceived (2/12)
Then, we measured whether #TimeToPregnancy differed by vaccination status or infection history. We accounted for many factors (like occupation, income, etc.) that may be related to fertility and vaccination or infection (3/12)
Read 12 tweets
‼️ EMA’s regular press briefing on #COVID19 vaccines and treatments will be broadcast live 🔴 today, 18 January, from 16:00 to 16:30 CET. #EMAPresser
👉ema.europa.eu/en/events/ema-…
Watch live 🔴

We are now starting our regular press briefing on #COVID19 vaccines and treatments.

Don’t miss our tweets during the press briefing. Follow #EMAPresser.
👉 ema.europa.eu/en/events/ema-…
Omicron & other variants: Global regulators agreed that the administration of multiple booster doses at short intervals would not be sustainable in the long term. #COVID19 #EMAPresser #ICMRA
Read 10 tweets
“Doctor, what should be my targets for Hba1c, Fasting and Post meal (PP) glucose?”

Many of our friends with Diabetes have this question. I will try to explain in the thread below.

#Diabetes #GlycemicTargets #HbA1c (1/n)
HbA1c should be done at least 2 times a year if goals are met and glucose control is stable,

Done more often if goals not met or there is change in the medicines.

A1c goal for many non pregnant adults is < 7% without any significant hypoglycaemia.

#Diabetes #HbA1c (2/n)
Tighter HbA1c goals ( less than 7%) may be considered in some.

Less stringent goals (less than 8%) may be appropriate in pts with limited life expectancy or side effect of drugs.

Individualisation of glycemic targets is a must. It’s not a one size fits all criteria.

(3/n)
Read 11 tweets
*New data* from 79,148 ppl giving birth in Scotland Mar 20 - Oct 21.

🦠 #COVID ⬆️ risk of stillbirth or neonatal death by ~4x, and preterm birth by ~2x

💉 #CovidVaccination protects against COVID and is not associated with poor #pregnancy outcomes. 1/

nature.com/articles/s4159…
This gives us some homegrown data on vaccine effectiveness in pregnancy, including in the delta wave. Roughly speaking, vaccination reduces the risk of...

Any infection by 30%

Hospitalisation by 72%

ICU by 94%

2/
The findings are roughly in line with what we already know about the outcomes of COVID in pregnancy.

We usually say that stillbirth is 3x more likely following infection. The slightly higher number here may be because they also counted babies dying shortly after birth... 3/
Read 8 tweets
🧵 Shared from a dr friend, details changed for patient privacy: Had 3 unvaxxed women in late pregnancy hospitalized w/ #COVID19 w/ emergency early deliveries. One dead, leaving 5 kids; one transferred out of state for ECMO (my note: most advanced life support) & dying anyway…
2/ One survived but had a stroke that left her with neurological disability so she will not be able to return to her home. Instead, she’ll spend her New Years’ Eve in a brain rehab. All the babies are expected to live, but these families are 💔. Two young moms dead, one disabled.
3/ #COVID19 is very dangerous in #pregnancy. The risk of death from #Covid is 22 times ⬆️ if you are #pregnant. The risk of stillbirth is doubled. Both @CDCgov & @ACOGPregnancy strongly rec to #GetVaccinated & #GetBoosted at ANY point in pregnancy, yet 2/3 in 🇺🇸 are unvaxxed.
Read 7 tweets
Live thread: 🐓 cockadoodle Wu! Rise and shine! @MayorWu planned to slip into rollcall to lecture, I mean visit the #Boston cops in area B-3. 100 protesters got up earlier #novaxpassports #novaxmandates @BostonFRU @mafamass @michellemalkin Image
@LOCAL_718 @BostonPatrolmen @mafamass Nice chilly crowd of protesters gathering to greet @MayorWu Image
Much of the #Boston media still wearing footie pajamas @TheKuhnerReport @WBZNightside @G_CURLEY @HowieCarrShow They choose health not @MayorWu CONTROL
Read 29 tweets
I know personally 3 people receiving monoclonal antibodies this evening. All have had 3 doses of #COVID19 #vaccine or prior infection + 2 doses of vaccine. All are careful. They all have risk factors, but all are pretty symptomatic. Jan is gonna be…rough. #MaskUp. #Omicron
Tweet 2: A lot of people seem to be panicking based on this anecdote. Panic is NOT productive. Instead you need to calmly plan & act to reduce your risk. These are some effective things you can do right now:
👉Upgrade your masks. No more cloth alone. Best is N95/KN95/KF94...
Tweet 3: As an alternative to N95/KN95/KF94, if you can't tolerate those or don't have them, I rec a surgical mask (ASTM level 3, 3-ply is great) w/ cloth mask over it. Read this: scientificamerican.com/article/why-we…. The non-profit @projectn95 has vetted, affordable PPE including masks.
Read 13 tweets

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