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After a few quiet months, the next release of #PyHMMER is out today with some new major features! 
You can now use a target database for search methods without having to load it entirely in memory, just pass a SequenceFile object directly (s/o @felixmlanger):
Also, there's now an `hmmscan` implementation! Target profiles can be either loaded from a pressed file (like the original), or pre-fetched into memory, which gives massive performance improvements if you can afford the extra RAM. A benchmark of 4,489 proteins against Pfam v33.1:
