Discover and read the best of Twitter Threads about #RET
Most recents (11)
1) Welcome to a new #accredited #tweetorial, "Utilizing Immunohistochemistry Testing, Biomarkers, and Targeted Therapeutics to Optimize Outcomes in Patients with NSCLC," featuring the highlights of a symposium presented at the #ESMOIO22 congress.
@myESMO #LCSM #FOAMed
@myESMO #LCSM #FOAMed
2) The faculty for this outstanding program were @peters_solange (Chair) 🇨🇭, @HosseinBorghaei 🇺🇸, Natasha Leighl MD 🇨🇦, and @dplanchard 🇫🇷. A truly international roster of experts in #oncology!
Don't miss prior accredited courses in this space at oncologytweetorials-ce.com/category/lung-….
Don't miss prior accredited courses in this space at oncologytweetorials-ce.com/category/lung-….
3) This program is supported by an educational grant from Sanofi. Statement of accreditation and author disclosures are at oncologytweetorials-ce.com/disclosures/.
I’m at the #RET this morning, going to be talking about future power prices - and looking forward to the panel discussion on market design!
ESO looking at “tactical” initiatives for this winter in the winter outlook to help with worst case scenarios - expect publication in august
NGESO: next NOA analysis will show significantly higher annual constraint costs than £2.5bn from last report
@TumorBoardTues Looking forward to the discussion on #RET #precisionmedicine
@Aiims1742
@ShaalanBeg
@weoncologists
@RETpositive
@MPishvaian
@StephenVLiu
@DrSteveMartin
@marklewismd
@neerajaiims
@montypal
@ADesaiMD
@jacobadashek
@n8pennell
@VamsiVelcheti
@kyawzinthein86
@Aiims1742
@ShaalanBeg
@weoncologists
@RETpositive
@MPishvaian
@StephenVLiu
@DrSteveMartin
@marklewismd
@neerajaiims
@montypal
@ADesaiMD
@jacobadashek
@n8pennell
@VamsiVelcheti
@kyawzinthein86
@TumorBoardTues @Aiims1742 @ShaalanBeg @weoncologists @RETpositive @MPishvaian @StephenVLiu @DrSteveMartin @marklewismd @neerajaiims @montypal @ADesaiMD @jacobadashek @n8pennell @VamsiVelcheti @kyawzinthein86 A healthy 56-year-old man presents with neck swelling persisting after 2 weeks of antibiotics. No congenital anamoly. PPD negative. #TumorBoardTuesday
What would you do next ? @marklewismd @StephenVLiu
What would you do next ? @marklewismd @StephenVLiu
@TumorBoardTues @Aiims1742 @ShaalanBeg @weoncologists @RETpositive @MPishvaian @StephenVLiu @DrSteveMartin @marklewismd @neerajaiims @montypal @ADesaiMD @jacobadashek @n8pennell @VamsiVelcheti @kyawzinthein86 Work-up led to total thyroidectomy+ bilateral neck dissection, a diagnosis of #thyroidcancer with lymph node spread #TumorBoardTuesday @hemoncwarner @RenoHemonc @AMansfieldMD @VamsiVelcheti @kyawzinthein86
Roman Dutch Laws & Anti Black Constitution imposed on you and you expect to be treated fairly, its impossible, those documents Justifies the dehumanization of a black race
How laws are weaponized against other race , to justify their dehumanization ,impoverishment and slavery
The rules can be changed overnight to criminalize certain behaviors whenever those with economic power dislikes the existence of certain things, example Radical Economic Transformation aka RET
A plan to shutdown the ANC policy "Radical Economic Transformation" by targetting certain Twitter accounts advocating for RET ,
it is regarded a crime advocating for the economic transformation in Ramaphosa's New Dawn
it is regarded a crime advocating for the economic transformation in Ramaphosa's New Dawn
"Radical Economic Transformation is a policy of the ANC" ~ cyril ramaphosa
Today what was said by the president is regarded as a crime by those who have power to get Twitter accounts they dislike suspended @Twitter @TwitterSupport @SABCNews
Given the recent advances in treating mutant RET+ cancer, I want to take this opportunity to highlight our publication in @Leukemia (2018) entitled “RET-mediated autophagy suppression as targetable co-dependence in acute myeloid leukemia”.
🧵 (1/13)
rdcu.be/b6yGD
🧵 (1/13)
rdcu.be/b6yGD
The #RET gene encodes a receptor tyrosine kinase (RTK), whose activating mutations are prevalent in solid-organ malignancies such as thyroid cancer (TC) or non-small cell lung cancer (#NSCLC). In contrast, the role of RET in haematologic malignancies is less well defined. (2/13)
We performed shRNA screens using #AML cell lines and identified RET as essential kinase. We validated these findings in competition and apoptosis assays where additional AML cell lines (+ or - for RET expression) were transduced with GFP-labelled shRNAs targeting RET. (3/13)
#OncoAlert Report @JTOonline on PDL1 variability in metastatic #NSCLC. A lot of intriguing information on this increasingly imperfect biomarker. Important to understand what's driving the heterogeneity and how it impacts treatment. @IASLC #LCSM
jto.org/article/S1556-…
jto.org/article/S1556-…
#OncoAlert In an analysis of 1398 patients with NSCLC they looked at patterns of PD-L1 expression and the impact of disease site and prior therapy. In a subset who received checkpoint inhibitors, they also looked at outcomes. Could influence how we look at PDL1 IHC. #LCSM
Lesson 1: PD-L1 varies by site. Previously reported. If the biopsy is from liver or adrenal, PDL1 runs higher. Brain and bone, PDL1 tends to be low. Some sets have small numbers but interesting trends and may reflect differences in the immune microenvironment #OncoAlert #LCSM
#DCLUNG19 Daunting task of all non-EGFR/ALK drivers in #NSCLC handled easily by @alexdrilon - in #ROS1, note that not all ALK inhibitors are ROS1 inhibitors. Variation in CNS activity. Many active drugs to consider. #LCSM #LCAM
#DCLUNG19 Highly active, CNS penetrant and well tolerated TKIs for #RET and #NTRK fusion positive cancers, outlined by expert @alexdrilon
#WCLC19 Registrational results for LOXO-292, now Selpercatinib, presented by @alexdrilon. This is a highly selective RET inhibitor with preclinical CNS activity. Enrolled remarkably quickly: 253 RET+ #NSCLC enrolled since May 2017! #OncoAlert #LCSM
#WCLC19 Selpercatinib patient demographics. Incredible waterfall plot! In previously treated ORR 68% and nearly all patients with some reduction. CNS ORR 91%. Even better in 1L: 85%! mPFS 18.4 months. Impressive results for #RET #NSCLC #OncoAlert
#WCLC19 Illustrative examples of the depth of response possible. Safety profile very reassuring. Impressive results from Selpercatinib - now awaiting update from BLU-667. A great time for #RET targeting! #OncoAlert #LCSM #PrecisionMedicine
#OncoAlert Important work by @RymaBenayed @MLadanyi in @CCR_AACR online now reviewing why RNA testing is critical for patients with #NSCLC in the important search for actionable driver alterations to guide proper therapy #LCSM
clincancerres.aacrjournals.org/content/early/…
clincancerres.aacrjournals.org/content/early/…
@RymaBenayed @MLadanyi @CCR_AACR #OncoAlert The authors analyzed 254 patients with lung adenocarcinoma who were driver negative by MSK-IMPACT (DNA based NGS) and had enough tissue for RNA sequencing with ARCHER. 232 successfully sequenced and they identified 36 driver events or 15.5% of these patients! #LCSM
@RymaBenayed @MLadanyi @CCR_AACR The most common were #ROS1 (28%), #NRG1 (14%), #ALK (11%), #RET (8%) and #NTRK (8%). Patients able to receive targeted therapy had the expected good outcomes. @ros1cancer @EGFRResisters @ALKLungCancer
Physical Activity and Exercise –––– Their massive role in our health and wellness, at ALL ages/ stages of life.
A #curatedthread with tips and resources ––
Tags: #PhysicalActivity #Exercise #PhysicalMobility #SixthVitalSign #HealthyAging #health #wellness
A #curatedthread with tips and resources ––
Tags: #PhysicalActivity #Exercise #PhysicalMobility #SixthVitalSign #HealthyAging #health #wellness
More –– #PhysicalActivity #Exercise #PhysicalMobility
Tips on Getting Started
m.gulfnews.com/news/europe/uk…
- Craft your 'why'/purpose
- Start slowly
- U may 'love' exercising OR Not
- Be kind to U
- Use 'why'& habit, Not willpower
- Plan,Prioritize
- Be flexible
-+Resistance, +Balance
Tips on Getting Started
m.gulfnews.com/news/europe/uk…
- Craft your 'why'/purpose
- Start slowly
- U may 'love' exercising OR Not
- Be kind to U
- Use 'why'& habit, Not willpower
- Plan,Prioritize
- Be flexible
-+Resistance, +Balance
More ––––#PhysicalActivity #Exercise #PhysicalMobility #SixthVitalSign
"Common Sense Guide To Exercise and Moving More!" ––– by @CorKinetic
20 Great Tips! 👇
"Common Sense Guide To Exercise and Moving More!" ––– by @CorKinetic
20 Great Tips! 👇
