Discover and read the best of Twitter Threads about #Recombination
Most recents (4)
First, kudos to the Chinese authors doing this work & a shoutout to @edwardcholmes also involved
I already flagged this Wang et al. preprint yesterday but it is worth explaining its significance to both the #origins discussion and the related pandemic #prevention discussion
A🧵
I already flagged this Wang et al. preprint yesterday but it is worth explaining its significance to both the #origins discussion and the related pandemic #prevention discussion
A🧵
First: Origins
One thing that goes often down in all the noise surrounding #lableak is the fact that SARS-CoV-2, and actually all CoVs, possess #mosaic genomes.
This is because CoVs evolve not only through mutation but also through exchanging genetic elements with other CoVs
2/
One thing that goes often down in all the noise surrounding #lableak is the fact that SARS-CoV-2, and actually all CoVs, possess #mosaic genomes.
This is because CoVs evolve not only through mutation but also through exchanging genetic elements with other CoVs
2/
This exchange is called '#recombination'.
One can imagine CoV genomes like colorful Lego brick walls, and recombination as taking one brick from a different virus and putting it in the wall of another; changing the color while keeping roughly the function.
3/
One can imagine CoV genomes like colorful Lego brick walls, and recombination as taking one brick from a different virus and putting it in the wall of another; changing the color while keeping roughly the function.
3/
🧵 "A #biologist's perspective of #process and #pattern in #innovation"
by SFI External Professor @HochTwit
Starting in just a few minutes on our YouTube channel.
Follow this thread for select slides and quotations...
youtube.com/user/santafein…
by SFI External Professor @HochTwit
Starting in just a few minutes on our YouTube channel.
Follow this thread for select slides and quotations...
youtube.com/user/santafein…
"I'm not going to pretend there's a unified theory of #innovation, and I'm going to explain why."
We begin with a tale of #Minitel: the original, now-extinct French "Web"...and then back further to #ARPANet...and then to theoretical precursors.
@HochTwit
We begin with a tale of #Minitel: the original, now-extinct French "Web"...and then back further to #ARPANet...and then to theoretical precursors.
@HochTwit
"There is no first-principles definition for #innovation."
"How could a company start with selling books online when people want to see a book in person and look through it? Nonetheless, @amazon survived..."
Before Amazon, Books.com on TelNet, later bought by B&N
"How could a company start with selling books online when people want to see a book in person and look through it? Nonetheless, @amazon survived..."
Before Amazon, Books.com on TelNet, later bought by B&N
1/ Both T cells and B cells undergo the process of genetic recombination. Their receptors are generated by randomly selecting genes from a very broad range of possible genes.
2/ This random genetic selection process is so similar between both T cells and B cells that it makes sense to cover them together. The key to remember is recombination happens at the DNA level, and it is permanent.
Ever wondered if and how #recombination of #retroelements contributes to #somatic #mosaicism? Read about it in our new pre-print:
Non-allelic homologous recombination of Alu and LINE-1 elements generates somatic complexity in human genomes. biorxiv.org/content/10.110…
Non-allelic homologous recombination of Alu and LINE-1 elements generates somatic complexity in human genomes. biorxiv.org/content/10.110…
1/ Background: pathogenic non-allelic homologous recombination (NAHR) of Alu and LINE-1 has been found in several genomic disorders and #cancer types. We thought this could be just the tip of the iceberg of a physiological recombinogenic activity of retroelements.
2/ The excellent Martin Frith developed a fresh pipeline to identify non-allelic homologous recombination (NAHR) in short and long-reads libraries: 🦖TE-reX🦖. It smartly focuses on split reads that join repeat elements at homologous positions.
