Discover and read the best of Twitter Threads about #Recombination

Most recents (4)

First, kudos to the Chinese authors doing this work & a shoutout to @edwardcholmes also involved

I already flagged this Wang et al. preprint yesterday but it is worth explaining its significance to both the #origins discussion and the related pandemic #prevention discussion

A🧵
First: Origins

One thing that goes often down in all the noise surrounding #lableak is the fact that SARS-CoV-2, and actually all CoVs, possess #mosaic genomes.

This is because CoVs evolve not only through mutation but also through exchanging genetic elements with other CoVs
2/
This exchange is called '#recombination'.

One can imagine CoV genomes like colorful Lego brick walls, and recombination as taking one brick from a different virus and putting it in the wall of another; changing the color while keeping roughly the function.
3/ Image
Read 18 tweets
🧵 "A #biologist's perspective of #process and #pattern in #innovation"
by SFI External Professor @HochTwit

Starting in just a few minutes on our YouTube channel.

Follow this thread for select slides and quotations...
youtube.com/user/santafein… Image
"I'm not going to pretend there's a unified theory of #innovation, and I'm going to explain why."

We begin with a tale of #Minitel: the original, now-extinct French "Web"...and then back further to #ARPANet...and then to theoretical precursors.


@HochTwit ImageImageImage
"There is no first-principles definition for #innovation."

"How could a company start with selling books online when people want to see a book in person and look through it? Nonetheless, @amazon survived..."

Before Amazon, Books.com on TelNet, later bought by B&N ImageImageImageImage
Read 15 tweets
#Recombination

The Process of VDJ recombination of T and B cells.
1/ Both T cells and B cells undergo the process of genetic recombination. Their receptors are generated by randomly selecting genes from a very broad range of possible genes.
2/ This random genetic selection process is so similar between both T cells and B cells that it makes sense to cover them together. The key to remember is recombination happens at the DNA level, and it is permanent. Image
Read 20 tweets
Ever wondered if and how #recombination of #retroelements contributes to #somatic #mosaicism? Read about it in our new pre-print:

Non-allelic homologous recombination of Alu and LINE-1 elements generates somatic complexity in human genomes. biorxiv.org/content/10.110…
1/ Background: pathogenic non-allelic homologous recombination (NAHR) of Alu and LINE-1 has been found in several genomic disorders and #cancer types. We thought this could be just the tip of the iceberg of a physiological recombinogenic activity of retroelements.
2/ The excellent Martin Frith developed a fresh pipeline to identify non-allelic homologous recombination (NAHR) in short and long-reads libraries: 🦖TE-reX🦖. It smartly focuses on split reads that join repeat elements at homologous positions.
Read 11 tweets

Related hashtags

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3.00/month or $30.00/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!