Discover and read the best of Twitter Threads about #Ribavirin
Most recents (3)
TODAY at #Virological: throughout the #COVID19 pandemic, there has been a tendency to underestimate the potential of #SARSCoV2 to mutate and adapt.
As the @US_FDA meets Tuesday to discuss #molnupiravir, @sarperotto and I fear another oversight.🧵
1/15
virological.org/t/mutagenic-an…
As the @US_FDA meets Tuesday to discuss #molnupiravir, @sarperotto and I fear another oversight.🧵
1/15
virological.org/t/mutagenic-an…
To be clear, I believe vaccines and antiviral drugs BOTH have critical parts to play in the fight against #COVID19.
Oral antivirals are of particular interest given their potential for equitable distribution.
This is NOT an argument against antivirals.
2/15
Oral antivirals are of particular interest given their potential for equitable distribution.
This is NOT an argument against antivirals.
2/15
Antivirals can work via several mechanisms.
🦠PROTEASE INHIBITORS, like #paxlovid and #masitinib, prevent the production of mature viral proteins.
🧬MUTAGENS, like #molnupiravir, instead increase the viral mutation rate to intolerable levels, causing LETHAL MUTAGENESIS.
3/15
🦠PROTEASE INHIBITORS, like #paxlovid and #masitinib, prevent the production of mature viral proteins.
🧬MUTAGENS, like #molnupiravir, instead increase the viral mutation rate to intolerable levels, causing LETHAL MUTAGENESIS.
3/15
1/
Should we use #Lopinavir-ritonavir (LPV/r) + #Ribavirin (RBV) +/- #Interferon beta-1b (IFN) to treat #SARSCoV2 #COVID19? Let’s take a look at the data.
Here’s: #HowIReadThisPaper on @TheLancet trial of triple therapy for COVID19
Hung et al: thelancet.com/journals/lance…
Should we use #Lopinavir-ritonavir (LPV/r) + #Ribavirin (RBV) +/- #Interferon beta-1b (IFN) to treat #SARSCoV2 #COVID19? Let’s take a look at the data.
Here’s: #HowIReadThisPaper on @TheLancet trial of triple therapy for COVID19
Hung et al: thelancet.com/journals/lance…
2/
First, let’s assess our baseline beliefs about triple therapy:
Before reading this study, when considering triple therapy as a treatment for patients with COVID19, I think the most important component is likely to be:
First, let’s assess our baseline beliefs about triple therapy:
Before reading this study, when considering triple therapy as a treatment for patients with COVID19, I think the most important component is likely to be:
3/
Background: A 2003 case series suggested ↓mortality (vs historical controls) in SARS patients treated with LPV/r + RBV :
ncbi.nlm.nih.gov/pmc/articles/P…
In 2015, LPV/r and IFN led to ↓viral load and improved clinical outcomes in animal models of MERS:
pubmed.ncbi.nlm.nih.gov/26198719/
Background: A 2003 case series suggested ↓mortality (vs historical controls) in SARS patients treated with LPV/r + RBV :
ncbi.nlm.nih.gov/pmc/articles/P…
In 2015, LPV/r and IFN led to ↓viral load and improved clinical outcomes in animal models of MERS:
pubmed.ncbi.nlm.nih.gov/26198719/
There is no proven effective antiviral drug for the treatment of #SARSCoV2
Several compounds are suggested for Rx of #COVID19. Based on the available in vitro and clinical data, which one is your preferred Rx, if available? #MayoIDQ references follow...
Several compounds are suggested for Rx of #COVID19. Based on the available in vitro and clinical data, which one is your preferred Rx, if available? #MayoIDQ references follow...
1/
#Chloroquine
Anti-malaria
Several potential mechanisms: change in cell membrane pH, impairs viral fusion, interferes with glycosylation of viral proteins
#chloroquine and #redemsivir are active against SARS-COV2 in experimental models
doi.org/10.1038/s41422…
#Chloroquine
Anti-malaria
Several potential mechanisms: change in cell membrane pH, impairs viral fusion, interferes with glycosylation of viral proteins
#chloroquine and #redemsivir are active against SARS-COV2 in experimental models
doi.org/10.1038/s41422…
2/
#Hydroxychloroquine
- Analogue of chloroquine
- Anti inflammatory effect
Hydroxychloroquine was more potent than chloroquine against #SARS-CoV2 in vitro.
doi.org/10.1093/cid/ci…
#Hydroxychloroquine
- Analogue of chloroquine
- Anti inflammatory effect
Hydroxychloroquine was more potent than chloroquine against #SARS-CoV2 in vitro.
doi.org/10.1093/cid/ci…
