Discover and read the best of Twitter Threads about #Ritonavir
Most recents (10)
1/ I'm really excited that the @US_FDA has granted an EUA for #Paxlovid - this is a terrific new option for #OmicronVariant and kudos to the scientists, researchers, and developers at Pfizer. So timely, and so necessary as we face a wave of new #COVID19 infections globally.
2/ I went through the fact sheet and it is critical to highlight that many patients with cancer and organ transplant recipients are on medications that will be effected by the #ritonavir component of #paxlovid.
3/ Note black box warning - Co-administration of ritonavir with sedative hypnotics, anti-arrthythmics, or ergot alkaloids are contraindicated.
Pfizer did a great job in compiling potential drug-drug interactions:
Pfizer did a great job in compiling potential drug-drug interactions:
In silico identification of natural products from Centella asiatica as SARS-COV-2 main protease (M pro) inhibitor. 1/n
❌❌❌ #ritonavir #molnupiravir in #COVID19
No more #tryglyceride #mutagenesis
pubmed.ncbi.nlm.nih.gov/34345605/
❌❌❌ #ritonavir #molnupiravir in #COVID19
No more #tryglyceride #mutagenesis
pubmed.ncbi.nlm.nih.gov/34345605/
2/n
Anti-Inflammatory and anti-vascular leakage effects by combination of Centella asiatica and Vitis vinifera L. (Grapevine) leaf extracts.
#antiinflammatory qualities #anti #vascular #leakage effect
hindawi.com/journals/ecam/…
#antiinflammatory qualities #anti #vascular #leakage effect
hindawi.com/journals/ecam/…
A tweet thread on AYUSH.
I think these traditional medicine systems are here to stay. They are of course pure junk, totally unscientific, snake-oil, voodoo medicine.. call it whatever pejorative term you like.. but they are here to stay.
Why are they here to stay?
I think these traditional medicine systems are here to stay. They are of course pure junk, totally unscientific, snake-oil, voodoo medicine.. call it whatever pejorative term you like.. but they are here to stay.
Why are they here to stay?
Well they are here to stay quite simply because many many people have faith in them. The source of this faith and whether it is faith backed by research is debatable but the fact is people have faith in them. Mainly upper caste Hindus when it comes to Ayurveda,
But homeopathy, Unani and Siddha have their own adherents.China is promoting its #TCM - traditional Chinese medicine and the English speaking world has its #AlternativeMedicine movement. On TCM see: economist.com/leaders/2017/0…
MEDICAMENTOS PARA #COVID19
Desde diciembre 2019 que se reportó el primer caso de infección por #SARS_CoV_2, han surgido un sinfín de tratamientos para esta infección.
¿Pero cual tiene suficiente evidencia científica?
Abro hilo
Desde diciembre 2019 que se reportó el primer caso de infección por #SARS_CoV_2, han surgido un sinfín de tratamientos para esta infección.
¿Pero cual tiene suficiente evidencia científica?
Abro hilo
Empecemos por dejar en claro varios puntos:
•#COVID19: Enfermedad provocada por la infección #SARSCoV2.
•#SARSCoV2: Nuevo tipo de #coronavirus que por sus siglas en inglés se refiere a 𝘴𝘦𝘷𝘦𝘳𝘦 𝘢𝘤𝘶𝘵𝘦 𝘳𝘦𝘴𝘱𝘪𝘳𝘢𝘵𝘰𝘳𝘺 𝘴𝘺𝘯𝘥𝘳𝘰𝘮𝘦 𝘤𝘰𝘳𝘰𝘯𝘢𝘷𝘪𝘳𝘶𝘴 𝟸
•#COVID19: Enfermedad provocada por la infección #SARSCoV2.
•#SARSCoV2: Nuevo tipo de #coronavirus que por sus siglas en inglés se refiere a 𝘴𝘦𝘷𝘦𝘳𝘦 𝘢𝘤𝘶𝘵𝘦 𝘳𝘦𝘴𝘱𝘪𝘳𝘢𝘵𝘰𝘳𝘺 𝘴𝘺𝘯𝘥𝘳𝘰𝘮𝘦 𝘤𝘰𝘳𝘰𝘯𝘢𝘷𝘪𝘳𝘶𝘴 𝟸
Es decir, puedes tener la infección pero no desarrollar la enfermedad.
Esto es importante para entender la clasificación los @NIH para la infección por #SARSCoV2:
1.- Asintomático
2.- Cuadro leve
3.- Cuadro moderado
4.- Cuadro severo
5.- Cuadro criticó
covid19treatmentguidelines.nih.gov/whats-new/
Esto es importante para entender la clasificación los @NIH para la infección por #SARSCoV2:
1.- Asintomático
2.- Cuadro leve
3.- Cuadro moderado
4.- Cuadro severo
5.- Cuadro criticó
covid19treatmentguidelines.nih.gov/whats-new/
🔥Voilà un thread afin de ne pas avoir à répéter tout le temps la même chose sur la recherche médicale thérapeutique pendant #COVID19 #SARS_CoV_2 #pandemic
👇👇
👇👇
1/ Les infectiologues cliniciens n'attendaient pas de ttt antiviral permettant une amélioration "spectaculaire" pr une maladie aiguë virale sévère (cf dengue, zika, chik, grippe), il était donc nécessaire d’évaluer rigoureusement et d’espérer un ttt un peu efficace et non toxique
2/ Il existe de nombreux candidats repositionnés qui ont été utilisés et testés et ce dès le début de la pandémie : #lopinavir/#ritonavir, #remdesivir, #hydroxychloroquine, #interferon ß pour n’en citer que quelques-uns
21/ #ZelenkoProtocol
1. Abstract Conclusion = Zinc helps
2. But: Paragraph 2 under METHODS
3. Essential to read study's methods
"Patients were *included* if ... had either been discharged from the hospital, transitioned to hospice or expired"
Full PDF:
drive.google.com/file/d/1XkIHqV…
1. Abstract Conclusion = Zinc helps
2. But: Paragraph 2 under METHODS
3. Essential to read study's methods
"Patients were *included* if ... had either been discharged from the hospital, transitioned to hospice or expired"
Full PDF:
drive.google.com/file/d/1XkIHqV…
22/ #Hydroxychloroquine & #Chloroquine & #Azithromycin
Norwegian Medicines Agency published a Warning April 23 & updated it on May 6.
Translates perfectly to English:
bit.ly/3fBSN5b
Citations:
medrxiv.org/content/10.110…
medrxiv.org/content/10.110…
#TrumpLiesAmericansDie
Norwegian Medicines Agency published a Warning April 23 & updated it on May 6.
Translates perfectly to English:
bit.ly/3fBSN5b
Citations:
medrxiv.org/content/10.110…
medrxiv.org/content/10.110…
#TrumpLiesAmericansDie
23/ #Remdesivir & #Vaccines & #SARSCoV2 & #COVID19
Norwegian Medicines Agency reports:
"Investigations started in Europe"
EMA - Remdesivir:
ema.europa.eu/en/news/ema-st…
NMA - Medicines & Vaccines:
legemiddelverket.no/english/covid-…
#TrumpPressConf #TrumpLiesAmericansDie
Norwegian Medicines Agency reports:
"Investigations started in Europe"
EMA - Remdesivir:
ema.europa.eu/en/news/ema-st…
NMA - Medicines & Vaccines:
legemiddelverket.no/english/covid-…
#TrumpPressConf #TrumpLiesAmericansDie
1/ Little Thread about all The Misleading Medical Information still floating around about #Hydroxychloroquine & #Chloroquine & #Azithromycin & #ZelenkoProtocol - by 1 doctor - @zev_dr & #Remdesivir & more
Despite #TrumpIsNotADoctor has stopped saying "What do you have to lose?".
Despite #TrumpIsNotADoctor has stopped saying "What do you have to lose?".
2/ #TrumpIsTheWORSTPresidentEVER
First, why it has been political all the way, suspected from day one:
"Trump had been touting HCQ for weeks, sparking worldwide shortages of HCQ & prompting negotiations with Indian PM Modi to lift export restrictions"
vanityfair.com/news/2020/04/i…
First, why it has been political all the way, suspected from day one:
"Trump had been touting HCQ for weeks, sparking worldwide shortages of HCQ & prompting negotiations with Indian PM Modi to lift export restrictions"
vanityfair.com/news/2020/04/i…
3/ #Trump2020
Indian PM Modi and Trump held a rally together.
"Mr Trump wanted to show people in the US that he was hugely popular abroad and that he was capable of negotiating good deals out of a country he once described as the king of tariffs"
bbc.com/news/world-sou…
Indian PM Modi and Trump held a rally together.
"Mr Trump wanted to show people in the US that he was hugely popular abroad and that he was capable of negotiating good deals out of a country he once described as the king of tariffs"
bbc.com/news/world-sou…
What evidence has the @JHSPH_NCRC reviewed to date on treatments for COVID-19? 💊💉🩸
From Gautret et al. in International Journal of Antimicrobial Agents:
Viral shedding appeared lower in the #hydroxychloroquine arm; however, important differences between groups may also explain the effect seen. bit.ly/2W5meov
Viral shedding appeared lower in the #hydroxychloroquine arm; however, important differences between groups may also explain the effect seen. bit.ly/2W5meov
From Gautret et al. in International Journal of Antimicrobial Agents:
The study did not formally assess clinical endpoints, and it is unclear whether there is #COVID19 clinical benefit with #hydroxychloroquine treatment. bit.ly/2W5meov
The study did not formally assess clinical endpoints, and it is unclear whether there is #COVID19 clinical benefit with #hydroxychloroquine treatment. bit.ly/2W5meov
Starting a series on clinical Pearls I am gathering in #COVID19 patients based on experiences of many experts
Will add as we go along
Feel free to add your own observations/experiences
#covidclinicalpearls /1
Will add as we go along
Feel free to add your own observations/experiences
#covidclinicalpearls /1
Anosmia is likely the most specific #COVID19 related symptom
30% of patients have anosmia as their 1st symptom
#covidclinicalpearls /2
30% of patients have anosmia as their 1st symptom
#covidclinicalpearls /2
Around 90% of patients have fever.
50% maybe afebrile at the time of presentation
Fever tends to be very resistant to routine measures in hospitalized patients
There is no consensus that NSAIDs are to be avoided in #COVID2019 patients
#covidclinicalpearls /3
50% maybe afebrile at the time of presentation
Fever tends to be very resistant to routine measures in hospitalized patients
There is no consensus that NSAIDs are to be avoided in #COVID2019 patients
#covidclinicalpearls /3
1er essai clinique #COVID19 pour les antiviraux #Lopinavir-Ritonavir (inhibiteur de protéase) : PAS DE BENEFICE
Pas de différence pour le délai d'amélioration clinique
Délai médian d'amélioration clinique :
Contrôle = 16j
Lopinavir = 16j
RR=1.31 [0.95-1.85]
#COVID2019france
Pas de différence pour le délai d'amélioration clinique
Délai médian d'amélioration clinique :
Contrôle = 16j
Lopinavir = 16j
RR=1.31 [0.95-1.85]
#COVID2019france
En analyse en intention de traiter modifiée, le lopinavir – #ritonavir a conduit à un délai médian d'amélioration clinique inférieur d'un jour à celui observé avec les soins standard
La mortalité à 28 jours était similaire des les 2 groupes (19,2% contre 25,0%)
La mortalité à 28 jours était similaire des les 2 groupes (19,2% contre 25,0%)
Les événements indésirables gastro-intestinaux étaient plus fréquents dans le groupe lopinavir – ritonavir, mais les événements indésirables graves étaient plus fréquents dans le groupe soins standard
