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#SIRT for advanced HCC has been recommended by @NICEComms. There may be some reasons for doing this but #costeffectiveness is not one of them. A short Tweetorial. @BSIR_News @cirsesociety @BASLedu nice.org.uk/news/article/h…
The relevant population here is people with advanced HCC. BCLC C, CP A, PS 1-2, unsuitable for conventional transarterial therapy (eg. portal vein thrombosis). These people have a dismal prognosis: most are dead within a year.
Treatment options are limited. Sorafenib is a protein kinase inhibitor and prolongs life slightly (vs best supportive care: SHARP trial) but at significant expense. It was originally rejected by NICE on this basis so Bayer applied via the Cancer Drugs fund (ie: reduced the cost). 
