Discover and read the best of Twitter Threads about #SarsCoV2

Most recents (24)

1/ Alla fine è arrivato. Dopo 26 mesi di isolamento, se non per le spese essenziali e passeggiate nei boschi. Un giorno della scorsa settimana il #SARSCoV2 ha raggiunto mio marito. Dopo la mamma 93enne, la badante, e il figlio, sono rimasta indenne solo io.
2/ Mio marito 67enne, oncologico, dializzato a forte rischio è POSITIVO. A riprova che in un mondo senza #mascherine proteggersi dal #COVID è impossibile. Dove si è contagiato non si sa
3/ In #dialisi? Dove tutti indossano maschera ma non è detto la indossino fuori (personale compreso), non è detto la indossino bene, e se convivi per 3 volte a settimana per ore finisce che se c’è un positivo lo prendi. Nasi fuori e finestre chiuse.
Read 18 tweets
Eine realistische Zusammenfassung aktuellen Situation. Man nennt es nicht so, aber Wegfall der Infektionsschutzmassnahmen läuft auf sich regelmäßig wiederholende Durchseuchungswellen hinaus. Wer schlau ist, versucht da nicht mitzumachen & sich vor Infektion zu schützen #SARSCoV2
#Schweiz kann immerhin interessante Daten liefern zur erhofften #Herdenimmunität: einige Kantone sind schon bei 97-98% Seroprävalenz. Trotzdem massives #Omicron BA.5 Infektionsgeschehen hier mit Hospitalisierung & Positivitätsraten ⬆️ corona-immunitas.ch/aktuell/seropr…
Gibt es eine einfache Lösung für dieses Dilemma? Nein. Wie lange brauchen wir noch Maßnahmen? Weiss niemand. Wie lange mutiert das Virus noch so schnell weiter? Weiss auch niemand. Aber: Ein Mindestmaß an Maßnahmen kann die Inzidenz senken & damit Krankheitsfolgen verhindern.
Read 3 tweets
#Flu and #SARSCoV2 in New South Wales (NSW), Australia to week ending 25JUN2022.
😷 #SARSCoV2 total positive numbers now rising again, as #flu positives decline. Image
😷#SARSCoV2 rate is ~100/100,000 population for all age groups and steady while for #flu, it varies by age, up to ~60/100,00 for those aged 0-9 years, and declining ImageImage
😷In terms of emergency department presentations, #flu-like illness is declining while #COVID19 presentations have stopped declining - slight⬆ ImageImage
Read 8 tweets
1/9 - “A surge in #COVID19 hospital admissions driven by the #BA5 of #Omicron, accompanied by the inability of vaccines to prevent reinfection, has prompted health policymakers to rethink their approach to boosters.”
ft.com/content/4f71ac…
2/9 - “Research into immune imprinting, whereby exposure to the virus via either infection or vaccination determines an individual’s level of protection, is now driving the debate over the make-up of #COVID19 vaccines.”
3/9 - “Immunologists say that, >2y into the pandemic, people have acquired very different types of immunity to the #SARSCoV2, depending on which strain or combination of strains they have been exposed to — leading to big diff in #COVID19 outcomes between indiv and countries.”
Read 9 tweets
1/5 - “In 169 Georgia elementary schools, #COVID19 incidence was 35% lower in 39 schools that improved ventilation through dilution alone and 48% lower in 31 schools that improved ventilation through dilution combined with filtration.”
jamanetwork.com/journals/jama/…
2/5 - “A simulation model found that filtration with 2 high-efficiency particulate air (HEPA) cleaners alone or combined with mask wearing could potentially reduce exposure to infectious particles by an estimated 65% or 90%, respectively.”
3/5 - “Many enhancements to ventilation and filtration can be made at no or low (<$100) cost: opening windows, inspecting and maintaining HVAC systems, and using fans to increase the effectiveness of open windows. Portable HEPA air cleaners can be added for a few hundred $ each.”
Read 5 tweets
A microscope on pandemics.
h/t @jvantill, @steeph, @PeterSpitters, @HMDatabase, @ArielKarlinsky, @hippopedoid.

🧵
1.Find age specific testing data and confirmed case fatality rates per given period of time.
2.Correlate confirmed #Covid19 deaths with reported excess mortality.
3.Correct the excess mortality rate for the fact that there is hardly any Influenza* around these days.
4.Combine all data in a spreadsheet (various equations with various unknowns) estimating general virus population prevalence.

*
5.Input calculated age specific infection risks, and time weighted vaccination% in a cross-sectional regression analysis.
6.Estimate regression parameters, that would describe mortality most likely caused by extraordinary #SARSCoV2 prevalence.

Read 5 tweets
"On June 28, the #FDA decided that henceforth THEY will choose the variants for reformulated #COVID19 shots and NO clinical trials will be conducted to evaluate #safety. Because $cience." ( tobyrogers.substack.com/p/the-end-of-c… ) #SARSCoV2 #VaccineSideEffects #EarlyTreatmentWorks
Via #FDA's #VRBPAC meeting, also linked in the piece ⬆️. ( ) #COVID19 #SARSCoV2 #VaccineSideEffects #EarlyTreatmentWorks
Read 7 tweets
It’s noteworthy #NevrePoilievre marched with ubiquitous & extremely dodgy character, Paul Alexander. Many have heard his name by now, but it’s important to note how Alexander keeps turning up. He wasn’t just a Trump appointee, he was handpicked by Michael Caputo. #Freedumbers
Michael Caputo created controversy, even within the Trump administration. Caputo has ties to both Putin & Roger Stone. So how he came to personally pluck Alexander, an obscure part-time instructor in 🇨🇦, to help him bully scientists at #HHS, is still a mystery to me. #cdnpoli
Paul Alexander shows up again & again. He was a central figure in #FluTruxKlan 1, & shows up again in #CoupTruxKlan 2.0. #cdnpoli #FreeDumbConvoy
Read 6 tweets
Was ich mich zum #SARSCoV2 #COVID19 #Evaluierungsbericht frage: Es gab offensichtlich nicht genug personelle Ressourcen für systematische Literaturrecherche. Viele Mitglieder sind Universitätsprofessoren mit sicher Zugang zu qualifizierten wissenschaftlichen Mitarbeitern -
Wieviel hätte es wohl gekostet ein paar Postdocs oder fortgeschrittene Doktoranden für einige Monate zu finanzieren um die Recherche & Datenextraktion vorzunehmen? Bei der Relevanz dieser Arbeit für jetzige & kommende Pandemien wäre dies doch eine sinnvolle Investition gewesen
Stattdessen gibt es jetzt einen Bericht ohne Methodenteil, der nicht nachvollziehbar macht, warum die genannten Studien berücksichtigt wurden & andere nicht, der bereits ganz am Anfang selbst anführt, dass das angestrebte Ergebnis nicht erbracht werden konnte.
Read 6 tweets
🔴 A lot of discussions have come up on the BA.2.75 variant of #SARSCOV2. A continuously updated 🧵on emerging evidence on this variant.
This variant was highlighted for designation recently. Majority of genomes have come from India 🇮🇳, apart from many other countries. github.com/cov-lineages/p…
Why is this lineage interesting?
⚪ Interesting because it has 9 unique changes in the spike protein incl. a reversion compared to the BA.4 and BA.5 subvariants of omicron now spreading widely across the globe.
Schema @mercy_rophina
Read 11 tweets
1/ I was asked by @TheLancet to write an editorial on #COVID19 vaccines for 5-11 year-olds: 6 months on, what have we learnt?

Importantly, what is the endgame?
Preventing infections? Severe disease? Long covid? And at what cost?

My tuppence worth …🧵

👉thelancet.com/journals/lance…
2/ My editorial was based on an Italian study on #COVID19 vaccines for 5-11y during Jan-Apr 2022:

VE ⬇️ from 65% (95% CI 62–68) in the 2 weeks after 2 doses to 12% (8–16) by 28-34 days

VE against hospitalisation was 41·1% (22·2–55·4) after 2 doses

👉 thelancet.com/journals/lance…
3/ This risk of severe #COVID19 in 5-11y was based on 644 hospitalisations (15 ICU, 2 died) which translated to:

- hospitalisation risk 0.08%
(84/100,000 infections)
- ICU risk 0.002%
(2/100,000)
- fatality risk 0.0003%
(0·3/100,000)

👉 I mean, how low can you go?🤷🏻‍♂️
Read 13 tweets
Hoy nos levantamos con la que, hasta ahora, es la mayor serie de casos de #monkeypox publicada del actual brote via @TheLancetInfDis. Muchos datos interesantes. ¡Hilo va! thelancet.com/journals/lanin…
El estudio describe 54 casos de #HSH diagnosticados en clinicas de ETS de Londres. Esto tiene algunos inconvenientes: no hay mujeres (que pueden padecer y padecen #monkeypox exactamente igual y con el mismo mecanismo de transmisión que los #HSH y varones heterosexuales)
Y se escapan algunos datos que no se recogen de rutina en las bases de datos de estos centros: sobre todo los gastrointestinales. Y es que algunas de las complicaciones que estamos viendo en 🇪🇦 se deben a obstrucción parcial faríngea por contagio oral pasivo)
Read 16 tweets
“Ik vertrouw op mijn #immuunsysteem!” Maar echt! Alleen snap ik niet dat je, als je dat immuunsysteem een handje kan helpen, ervoor kiest dit niet te doen. Met de #SARSCoV2 #zomergolf in volle gang dus tijd voor een draadje over #vaccins en jouw en mijn immuunsysteem. 1/15
Eerst de basis: ons lichaam heeft tal van barrières om je te beschermen tegen #infectie en ernstige #ziekte. Van o.a. de #huid en #slijmvliezen; bedoeld om #pathogenen = #ziekteverwekkers buiten te houden, tot speciale cellen die in actie komen om hen te bestrijden. 2/15
We hebben voor elke ziekteverwekker een oplossing. Voor de meeste kent ons lichaam na verloop van tijd zelfs al het recept voor de juiste antistof. Ons immuunsysteem is prachtig! Maar bij een nieuw virus zoals #SARSCoV2 is dat anders. Ons lichaam herkent het niet snel genoeg 3/15
Read 18 tweets
#LongCovid ist eine Krankheit, die durch eine Vielzahl klinischer Symptome, einschließlich neurologischer und vaskulärer Symptome, gekennzeichnet ist. Da man davon ausgeht, dass eine Autoimmunkomponente an der Pathogenese von #LongCovid

#COVID19
#coronavirus
#SARSCoV2 Image
…beteiligt ist, ergaben die Daten der vorliegenden Studie, dass eine Seropositivität von GPCR-AAb (funktionelle Autoantikörper) bei Patienten mit #LongCOVID einen Einfluss auf die gestörte Mikrozirkulation in der Netzhaut hatte, die mit OCT-Angiographie (OCT=Optische… Image
…Kohärenztomographie) abgebildet wurde, einer Methode zur Darstellung durchbluteter Netzhaut- und Aderhautgefäße ohne Gabe eines Kontrastmittels.
Die vorliegende Studie könnte darauf hindeuten, dass eine Seropositivität von GPCR-AAbs mit einer gestörten retinalen kapillaren…
Read 5 tweets
2. Dass es gelingen kann, die vorhandenen Hürden zu überwinden, zeigt die Zulassung des pflanzenbasierten Impfstoffs Covifenz in Kanada. An Zulassungen in weiteren Ländern wird gearbeitet. Der Notfallzulassung durch die WHO steht jedoch offenbar die Beteiligung des ...
3. ... Zigarettenherstellers „Philip Morris International“ an der Firma Medicago im Wege. Die WHO hat sehr strenge Regeln, was Partnerschaften mit Unternehmen aus Tabak- und Rüstungsindustrie betrifft. Wenn es hier keine Lösung gibt, wäre Covifenz der erste im Westen ...
Read 16 tweets
1/ Dangerous spread of misinformation by @BBC.

Do not be vaxed relaxed. Triple vaccination and prior infection with omicron #BA1 does not offer protection omicron variants #BA4 and #BA5 - which are currently driving the new wave of infection in the UK. 🧵
2/ #BA5 resists and escapes neutralising antibodies induced by triple-dose vaccination & antibodies induced by prior omicron (#BA1) infection.
3/ Please do all you can to prevent (re)infection. #COVIDisAirborne which means infectious particles are carried in the air we breathe. To protect yourself wear a good-fitting #FFP2 or #FFP3 mask 😷 especially when in indoor public spaces.
Read 5 tweets
This new #SARSCoV2 Omicron subvariant (BA.2.75) flagged here by @PeacockFlu is worth tracking, as it has appreciable antigenic change relative to its parent BA.2. Key mutations: G446S & R493Q

Here is summary of what those mutations imply for antibody escape & ACE2 affinity (1/n)
As I discussed last month, G446S is at one of most potent sites of escape from antibodies elicited by current vaccines that still neutralize BA.2: So for immunity from vaccines or early infections, adding G446S to BA.2 will decrease neutralization (2/n)
However, G446S will have less effect on antibodies of people with prior BA.1 breakthrough infection: . Therefore, BA.2.75's antigenic advantage relative to BA.2 will be most pronounced in people who have NOT had BA.1 exposure. (3/n)
Read 13 tweets
1/ Bad advice. Do not be vaxed relaxed. Omicron variants #BA4 and #BA5 - which are currently driving the new wave of infection, - resist & escape neutralizing antibodies induced by triple-dose vaccination & antibodies induced by prior omicron (#BA1) infection. 🧵
2/ Triple vaccination & prior omicron infection with #BA1 confer no protection against the new variant.
3/ Please ignore notorious Covid-minimiser, Prasad.

‘93-98%’ of people will not get #COVID19 if they wear a good-fitting #FFP2 or #FFP3 mask.

(Re)infection is not ‘inevitable’ and should be avoided. Continue to protect yourself.
Read 6 tweets
Globally, #COVID19 cases has increased for the 3rd consecutive week with >4.1million cases reported to @WHO (18%⬆️ compared to previous week). During the same week, 8,552 fatalities were reported.

We @WHO know both are underestimates and both cases & deaths are too high.

1/🧵
Global hot spots can be seen in these figures from our latest @WHO #COVID19 Weekly Epidemiological Update available here:

who.int/publications/m… 2/
In this edition we also provide:
↗️An update on the circulating #SARSCoV2 variants of concern
↗️ A special focus on relative vaccine effectiveness

#Omicron is still dominant: BA.2 represents 25% of sequences, BA.2.12.1 11%, BA.4 12%, & BA.5 43%. #BA4 & #BA5 reports are ⬆️

3/
Read 5 tweets
Ich denke wir erleben derzeit eine dramatische Untererfassung des #Corona-#Infektionsgeschehen|s durch offizielle Zahlen.Der Eindruck aus meinem privaten und geschäftlichen Umfeld suggeriert, daß schon jetzt - mitten im Sommer - die Höhe der ersten #Omikron-Welle erreicht wurde🧵
2/19
Die Schule meiner Kinder ist entvölkert, meine Twitter-Timeline voll mit Infektionsmeldungen und meine Geschäftstätigkeiten kommen aufgrund des Krankenstandes bei den Kunden fast zum Erliegen.
3/19
Derweil herrscht von Seitens der Politik erstaunliche Stille. Während man in Bayern über die Abschaffung der #Maskenpflicht - noch vor dem Peak der aktuellen Welle nachdenkt, geben sich zeitgleich auch vernünftige Klinikchefs recht entspannt.
Read 19 tweets
📍NEW DOMINANCE of “ESCAPE ARTIST” Variants #BA5 & #BA4–together topping 52% of all strains in the US, all while #BA2 family going extinct. ➡️BA5&4 are highly evasive against past immunity—matches rise in #COVID19 hospitalization in US & many countries.🧵 covid.cdc.gov/covid-data-tra…
2) this is why FDA has recommended for updates booster shots— The panel’s vote paves the way for F.D.A. to push manufacturers to make reformulated boosters in time for Biden WH to offer them later this year, before an expected winter surge of the virus.
nytimes.com/2022/06/28/us/…
3) #BA5 has begun causing havoc in hospitalizations worldwide in many countries. Especially recently in Portugal that had a wave of hospitalization that neared it’s winter peak. UK is now being squeezed by BA5/4 too. 👇
Read 8 tweets
It's been a little over 2 weeks since I cut off ties to my former friend group including my best friend for being covidiots. I feel even more resolved in my convictions now. There is not a single word that could be uttered by them for me to forgive them. #CovidIsNotOver 1/
They chose this reality of denialism and bullshit hopium and lies. They chose to wear these blinders while their actions negatively affect the lives and safety of others. They chose to not see me as a high risk person and to willfully ignore my calls for caution. 2/
They chose to attack me and call me paranoid for being safe and informed. They chose to defend everyone in the group for their careless actions without even trying to see my perspective and how I was hurting while being ignored and left behind. 3/
Read 10 tweets
#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (15-DAY TRENDS):

46.66% BA.2.12.1**,
23.33% BA.5^^,
12.15% BA.4^^,
7.64% BA.2,
4.24% BA.5.1^^,
1.29% BA.2.9 and
1.17% unassigned

**S:L452Q; ^^S:L452R/F486V

Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 6/27/22
#OmicronVariantUpdates #UnitedStates 06/27/22

Top 5 lineages:
BA.2.12.1, ⬇️ (Spike: L452Q)
BA.5, ⬆️ (Spike: L452R)
BA.4 ⬆️ (Spike: L452R)
BA.2 ⬇️
BA.5.1 ⬆️👀 (Lineage prevalent in #Portugal)

* includes recently designated BA.2.x.y and undesignated BA.2s
#SARSCoV2 lineages in USA (#15DayTrends)

Circulating #BA5*/#BA4* sub-lineages:
BA.5, BA.4.1, BA.5.2.1, BA.5.1, BA.4, BA.5.2, BA.5.3.1, BE.1, BF.1, BA.5.3

Assignments via: #Nextclade #PANGO - clades.nextclade.org
Read 13 tweets
⚠️Very worried about #BA5 causing #COVID19 hospitalization surges everywhere it goes—bad it’s very past-immunity-evasive. Portugal hit 80-90% of its old hospitalization peak recently. UK hospitals strained to the brink now too. Bad trends many in places.🧵

HT @jburnmurdoch
2) based on models, #BA5 and it’s close cousin #BA4, also past-immunity evasive, is surging so fast, it will likely be 50% of all #SARSCoV2 strains in the Us this week—and soon displacing all other past strains.

HT @JPWeiland
3) Why do we need to look at Portugal? It’s a highly vaccinated country, yet #BA5 has completely overwhelmed it. Vaccines work overall, but if a virus spreads unchecked without OTHER MITIGATIONS, vaccines not enough alone. We need vaccines+ PLUS other mitigations.
Read 11 tweets

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