Discover and read the best of Twitter Threads about #SarsCoV2

Most recents (24)

Our new preprint on the spread of the #SARSCoV2 variant Alpha in Geneva, Switzerland, and Beta in South Africa is online. We used clinical and epidemiological data to better understand the mechanisms that lead to a transmission advantage of the #VOCs. 1/8 doi.org/10.1101/2021.0… Image
When analyzing viral load in 950 individuals, we found that Alpha infections exhibit a higher viral load and longer viral shedding compared to non-VOC. 2/8 Image
We then used a transmission model to study the following potential mechanisms that result in a transmission advantage: i) increase in transmissibility, ii) increase of infectious duration, and iii) immune evasion. 3/8 Image
Read 8 tweets
Hay que empezar a decirle a la gente que en relación a #SARSCoV2, salvo catástrofe, no vamos a volver nunca a marzo de 2020.
Ni a septiembre de 2020.
Ni a enero de 2021.
Estamos en "otra pantalla".
Se acaba esta fase.
Lo intento explicar en un #HiloYTal en directo.
Tengo un rato.
Como estoy saliente de guardia, para no liarme usaré anclas.
1⃣ Somos un colador tupido.
2⃣ La catástrofe.
3⃣ Las vacunas.
4⃣ El futuro y los sustitos.
Vamos a ello.
1⃣ Somos un colador tupido.

Este virus nos ha hecho polvo porque TODO EL MUNDO se tuvo que enfrentar a él a ciegas. Hace un año todos éramos primerizos, no había leucocitos con la lección aprendida. Y claro, no es lo mismo hacerlo desde la flexibilidad que desde la rigidez.
Read 30 tweets
1/9 Weekly #COVID19 update from our 5 academic med centers: 8,449 #SARSCoV2 positive patients admitted to date in our 12 hospitals; 5,851 discharged home to date. @UofCAHealth hospitals cared for 57 #SARSCoV2 positive inpatients yesterday. Some inpatient tests may be pending.
2/7 21 #SARSCoV2 positive inpatients are in one of our Intensive Care Units. Note the rest of these ICU beds are not empty; patients with pending results and with other conditions besides #COVID19 are also in the ICU.
3/7 13 #COVID19 @UofCAHealth inpatients are on a ventilator. 6 COVID19 inpatients are on extracorporeal membrane oxygenation (ECMO).
Read 7 tweets
🧶Vacunas vs Delta, el coco de las nuevas variantes de #SARSCoV2
La variante Delta (B.1.617.2) identificada por primera vez en la India es un duro desafío para el control de la pandemia. Estudios recientes indican que es la más contagiosa de todas las identificadas hasta hoy. 1/n
De hecho, la preocupación por el surgimiento de nuevas variantes, incluyendo la Delta, con potencial para evadir la inmunidad conferida por la infección natural o las vacunas aprobadas para COVID-19, ha sido una constante en los últimos meses. 2/n
📷| @NatureMedicine
🔴 La buena noticia viene aquí. Un análisis en 🇬🇧 publicado hoy, muestra que la 💉 de Pfizer-BioNTech previene 94% de las hospitalizaciones tras la D1 y 96% tras la D2, para los casos de infección con Delta. Para AstraZeneca-Oxford, los datos son 71% (D1) y 92% (D2). 3/n
Read 4 tweets
It's been a busy few days/weeks/months modelling steps 2, 3 and 4 of the #roadmap out of lockdown in England, with my #ateam @_nickdavies @markjit and John Edmunds. A 🧵 on our latest work looking at #step4 🪜👩‍💻 and a #photodump of some nice things I saw along the way A photograph of the West pier and Brighton beach with low ti
We project the dynamics of #SARSCoV2 transmission in England using an #agestructured #transmission #model which divides the population into vaccine states and disease states. The model has compartments for three #COVID19 variants (OG, #alpha and #delta) and 2 two-dose vaccines 💉 An illustration of the age-structured compartmental transmis
To capture changes in behaviour (➡️ the amount people mix in the model), we use historic #mobilitydata and make assumptions about what might happen to mobility when policies are implemented, e.g. #step4 🍀 We make low, medium and high assumptions to account for uncertainty... ⭐️ Figures showing google mobility data between January 2020 an
Read 11 tweets
1/9 Daily #COVID19 update from our 5 academic med centers: 8,446 #SARSCoV2 positive patients admitted to date in our 12 hospitals; 5,852 discharged home to date. @UofCAHealth hospitals cared for 54 #SARSCoV2 positive inpatients yesterday. Some inpatient tests may be pending. Image
2/7 20 #SARSCoV2 positive inpatients are in one of our Intensive Care Units. Note the rest of these ICU beds are not empty; patients with pending results and with other conditions besides #COVID19 are also in the ICU. Image
3/7 11 #COVID19 @UofCAHealth inpatients are on a ventilator. 5 COVID19 inpatients are on extracorporeal membrane oxygenation (ECMO). ImageImage
Read 7 tweets
Flipad muy mucho. En magenta, células expresando la proteína ACE2, la que usa #SARSCoV2 para infectar y en verde,otras expresando la proteína Spike del virus. Este trabajo demuestra que la prot. Spike interactúa con el colesterol de las membranas para inducir la entrada del virus
Esta interacción favorece la formación de sincitios celulares de infección (algo que hacen muchos tipos de virus). Se preguntan los autores si las estatinas que disminuyen los niveles de colesterol podrían servir como tratamiento para el COVID-19 🤔
El artículo (y los vídeos flipantes) lo podéis leer aquí elifesciences.org/articles/65962…
Read 5 tweets
#DELTA DIARY: It is clear we are now dealing with a virus that spreads far more easily - probably more than twice as easily - as the version that emerged in #Wuhan at the end of 2019 1/

science.thewire.in/health/face-wi…
The #Ro was around 2.5 when the pandemic started in Wuhan and could be as high as 8.0 for the Delta variant 2/
DELTA is evolving: A new, more genetically diverse cluster, lineage AY.1 (which is termed as #Delta+) with a new spike substitution #N417K having immune escape property, has emerged independently in some countries @vinodscaria 3/
Read 9 tweets
A large team of virologists from several insts in China have discovered #SARSCoV2 - like viruses in bats in Yunnan Province. This pre-print contains much of interest.
- 411 bat samples were collected between May 2019 & Nov 2020.
MORE
cell.com/cell/pdf/S0092…
2/
- genome analysis shows 4 novel #SARSCoV2 -related viruses
- 3 of them carry a genetically distinct spike gene that could weakly bind to the human ACE2 receptors in vitro
- and 3 other viruses were found, similar to the one that caused #SARS in 2003

MORE
3/
- the ecological niche for these bats stretches from South Laos & Vietnam & Myanmar to southern China
- genetic sequence identity for #SARSCoV2 and original #SARS of new-found viruses ranges from 94 to 97.7%
- some genomic clustering with pangolin virus seen
MORE
Read 4 tweets
Eine guter Artikel, der das "Dilemma" der Kinderimpfung & die Entscheidung der Stiko gut erläutert. Interessant wird wohl auch Schutzwirkung zu #MISC / #PIMS sowie #Longcovid #SARSCoV2 #COVID19 zeit.de/gesundheit/zei… via @zeitonline
Dies ist in den vorliegenden Studien noch nicht untersucht. Ergänzen kann man die Diskussion noch um einen weiteren Aspekt: Auch ohne Impfung kann man weiterhin durch Schutzmaßnahmen Infektionen verhindern & ⬆️ Durchimpfung bei den Erwachsenen kann Gesamtzirkulation bei allen ⬇️
Ich wünsche mir, dass das Thema Impfung & Kinder nicht genauso politisiert wird wie im letzten Jahr die Rolle der Kinder in der Pandemie. Dies hilft niemandem. Kinder & Junge haben schon genug Opfer gebracht in der Pandemie & verdienen beides: Infektionsschutz & Förderung
Read 6 tweets
Muchas personas me preguntan ¿por qué en Chile con el 59% de la población vacuna con ambas dosis siguen habiendo cerca de 8 mil casos nuevos diarios y las UCI están colapsadas con pacientes Covid-19? Hay varios factores que influyen. Abro hilo para explicar la situación actual:
1. Ha habido una constante mala comunicación de riesgo por parte de las autoridades, contradiciendo los mensajes: Ej "un cafecito con los amigos", largas y flexibles cuarentenas, permiso de vacaciones, pase de movilidad, gran aforo para entrar a malls y muy poco para ir a parques
2. El comportamiento de la gente que, toma estos mensajes y reacciona como si no existiera pandemia, relajando las medidas de seguridad. Vemos largas filas para entrar al Costanera Center por ejemplo. Tampoco pueden todos cumplir las cuarentenas sin una ayuda económica rápida.
Read 10 tweets
Avec la vaccination des plus jeunes va se poser la question des intervalles de vaccination, et de la co existence de plusieurs injections. #Vaccin #COVID19

Que peut on "mixer", comment, et avec quel intervalle ?

⤵️
Principe général

En principe, tous les vaccins non vivants peuvent être réalisés le même jour ou avec n’importe quel intervalle de temps, selon le site InfoVac

infovac.fr/actualites/bul…
Ce même site "en l’absence de données spécifiques et pour faciliter la surveillance en pharmacovigilance des vaccins COVID-19, il a été recommandé de ne pas administrer d’autre vaccin entre les 2 doses ; et de respecter un délai d’au moins 2 semaines après la 2de dose" ⤵️
Read 7 tweets
ARTIFICIALE E NATURALE: L’ORNITORINCO DEI VIRUS – PARTE 2
Eccoci qua! Secondo thread su origine di #SARSCoV2!
Dopo avervi spiegato perchè il virus potrebbe essere artificiale (ma anche no!), oggi invece vi raccontiamo perché NON abbiamo delle prove che il virus sia naturale 1/ Image
Se #SARSCoV2 è naturale, esiste un animale portatore, cioè animale in natura infettato da un virus quasi identico a quello umano. Non vale 92,4% del #coronavirus nei pangolini malesi, né 96,2% del virus trovato nei pipistrelli ferro di cavallo. Punto. 2/
Come per le scale in Harry Potter, anche ai virus piace cambiare. Pipistrello e pangolino potrebbero essere “serbatoio” naturale, da cui #SARSCoV2 è arrivato a noi, attraverso varie mutazioni e salti di specie intermedi. Il punto è ricostruire la mappa degli eventi. 3/
Read 12 tweets
#InternationalBankingCartel Themes at 2021 G7 Meeting

#ClimateChange

+

#PublicHealth & the #ChinaVirus Outbreaks

+

Gender "Fluid" + LGBT + Anti-Testosterone (Strong, Aggressive White Men are Bad)

#EyesOpenFolks
#DemocratCorruptionNetworks
Where have All the Cowboys Gone ?

Read 20 tweets
du @BeatGlogger @higgsmag wäre das ein vorschlag für 1 gemeinsames #feedlog

wir gehen die punkte durch:
- und zeigst, was #ClemensArvay nicht korrekt auf die reihe bekommt? (so?) #CoronaViurs

#thread: "mRNA-Impfstoffe: Erste Hinweise auf Langzeitfolgen"
@BeatGlogger @higgsmag 1. aussage: mRNA-impfstoffe, könnten ihr immunsystem "nachhaltig" reprogrammieren
@BeatGlogger @higgsmag 00:00:31 dein werbesponsor @JNJ_ch wird erwähnt.
Read 24 tweets
We have just released a new version of the Nextclade web application clades.nextstrain.org for #SARSCOV2. We now use Nextalign (C++ via wasm) under the hood, which allows for many new exacting features!

A quick tour!

1/7
Analysis now takes a few seconds to start, but overall it has become much faster and analyzing hundreds of sequences should be no problem. You can download the reference alignments, including translations of SARS-CoV-2 genes, for further analyses.

2/7
You can now examine the diversity of the nucleotide alignment and alignments of different proteins. Select a gene from the drop-down or click on a gene in the genome annotation panel below.

3/7
Read 7 tweets
🧬6/10 Connecticut #SARSCoV2 variant surveillance
@CovidCT | @jacksonlab | @CTDPH | @YaleSPH | @Yalemed | @YNHH

Alpha (B.1.1.7) = 57% (📉11%)
Gamma (P.1) = 10.9% (📈2.7%)
Delta (B.1.617.2) = 6.5% (📈3.2%)

short 🧵 | Report 👉
covidtrackerct.com/variant-survei…
2/7 Gamma (P.1) and Delta (B.1.617.2) continue rising in Connecticut, while Alpha (B.1.1.7) and others decline, following national trends (see next tweet).
3/7 Data from outbreak.info shows that in the US 🇺🇸, Delta (B.1.617.2) is 📈 exponentially, while Alpha (B.1.1.7) is on the 📉. Despite this, COVID-19 cases are still dropping (for now).
Read 8 tweets
PAY ATTENTION—the #DeltaVariant is the biggest worry & becoming more dominant worldwide. Why?

📍More contagious

📍More severe (⬆️hospitalization risk)

📍Lower vaccine efficacy/neutralization—1 dose just not enough.

Video 📺 part 1 of 2 #COVID19

HT @VickiGSP @IndependentSage
2) It’s critical to recognize that the #DeltaVariant is rising underneath the decrease of the #AlphaVariant #B117. Many have been complacent about this. But Delta is doubling every week now in 🇬🇧! Image
3) India 🇮🇳 doctors have been sharing concerns that #DeltaVariant is more severe / affecting more kids. Singapore 🇸🇬 MOH is also warning it is affecting children a lot. Image
Read 32 tweets
Just like primary schools, we found limited #sarscov2 infection or transmission when UK secondary schools reopened fully from Sep-Dec 2020

We measured #COVID19 antibodies in blood, which captured symptomatic & asymptomatic infections in students & staff

sciencedirect.com/science/articl…
Between Sep & Dec 2020, 8.7% (57/652) staff & 6.6% (36/549) students seroconverted (antibody -ve ➡️ +ve) (p=0.16)

At the end of term, antibody positivity rates were similar in staff & students, & comparable to local community antibody positivity rates

sciencedirect.com/science/articl…
This is yet another study showing that schools are not filled with asymptomatic kids spreading #SARSCoV2 to others. If that was the case, antibody positivity rates would be much higher (esp. in kids) as seen in care homes, hospitals, prisons, etc (30-60%)

sciencedirect.com/science/articl…
Read 3 tweets
There is hope for American hospital systems after all.

Old friend of mine (who isn't really local to me and who shall remain nameless) requested help presenting with 76% SpO2 ambulatory at least 10 days post #SARSCoV2 infection.

Rule#1: don't panic the ill by conveying severity
Pt obtained ivermectin. We immediately began IVM+NAC+doxycycline+ASA. SpO2 popped to 87% within one hour - no doubt thanks to NAC. Gradually declined back to 82% after 5mg of melatonin and attempts to sleep for the evening. Obvious signs of hypoxemia = 911 & hospital transport.
Instantly landed in ICU. Critical care docs stabilized using high flow 80% FiO2 5L (bipap at night), low dose dex, and anticoagulation therapy, Over the course of several days (and after #remdesivir failure), I fed the ICU doc (via FB messenger) some of the molecular biology...
Read 5 tweets
Thanks to #opendata sharing via @GISAID, we've updated nextstrain.org/ncov with 10836 new #COVID19 #SARSCoV2 sequences!

1/4
You can see new sequences from Australia, Guadeloupe and Mexico on nextstrain.org/ncov/oceania and nextstrain.org/ncov/north-ame….

(Thanks to @SAHealth, @JMPawlotsky, @APHP, @Inserm, @institutpasteur, @todoscicese)

2/4
Check out new sequences from Belarus, Singapore, Taiwan and Vietnam on nextstrain.org/ncov/europe and nextstrain.org/ncov/asia.

(Thanks to RRPCEM Belarus, @mysgh, @Taiwan_CDC, @OUCRU_Vietnam)

3/4
Read 4 tweets
Gene Editing Recipe Continued: “Cell activity control is achieved using magnetic compounds such as ferritin or magnetic nanoparticles. These compounds are designed to link to the ion channels that are genetically expressed 1/2

en.wikipedia.org/wiki/Magnetoge…
on specific cells. Control of activity is thus restricted to genetically pre-defined cells and performed in a spatiotemporal-specific manner by magnetic stimulation.” 2/2
EXPOSED! Magnetism INTENTIONALLY Added to ‘Vaccine’ to Force mRNA Through Entire Body

redvoicemedia.com/2021/06/expose…
Read 26 tweets
IL CORONAVIRUS DI SCHRÖDINGER: ARTIFICIALE E NATURALE - PARTE 1
Ok, affrontiamo l'elefante nella stanza: da dove deriva #SARSCoV2 ? Un thread per spiegarvi perchè NON siamo certi sull’origine del nuovo coronavirus. Noi ricercatori siamo così: nessuna prova, nessuna parola 1/
Immaginate la vostra palazzina inondata dall’acqua, causa un tubo rotto. Di domenica. Agosto. Prima delle ferie. La frustrazione di quel momento può portare nostro cervello primordiale a cercare e creare una risposta. "Colpa del vicino invidioso, il tubo passa nel suo muro!" 2/
È uno scenario abbastanza improbabile, no? Anche la casa del vicino è inondata! Ecco, credere all’ipotesi del virus creato in laboratorio e volutamente messo in circolazione non è diverso da questa storiella. Aggiungiamo però anche altri aspetti su sequenza di #SARSCoV2 3/
Read 10 tweets
Pro-vaccine fanatics describe anyone who is against being jabbed with experimental, man-made lab concoctions as experiencing “vaccine hesitancy." The fact remains all 4 of the #COVID19 vaccine manufacturers have criminal rap sheets longer than the Mississippi River.

So back off.
#AstraZeneca has already shelled out hundreds of millions of $ in lawsuit settlements for off-label drug marketing & kickback schemes & now they’ve created this horrific failure of a covid-19 💉 called Vaxzevria, a viral vector vax, like the toxic, blood-clotting jab made by J&J.
Any vaccines that cause blood clots and death come highly recommended by the World Hate Organization (WHO), and the Centers for Disease Continuation (CDC), just like the deadly Astra-Z #SARSCoV2 jab.
Read 4 tweets

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