Discover and read the best of Twitter Threads about #Schwannoma

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📢 #Pathology #tweetorial alert!
⚕️ Dx: Plexiform #Schwannoma (aka neurilemmoma)

🔬 Multiple (2-50) nodules or foci of fascicular expansion.
🔬Biphasic: dense hypercellular areas (Antoni A) + loose hypocellular areas (Antoni B)

Scroll down ⬇️ #dermpath #BSTPath ImageImageImage
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A plexiform multinodularity is typical of plexiform schwannoma on gross examination.
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Usually sporadic (90%)
NF2 associated (5%)

NF2 gene on 22q12 ➡️ merlin.
🆚
Plexiform neurofibroma is associated with germline mutation of NF1 (17q11.2 ➡️neurofibromin)
sciencedirect.com/science/articl…
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