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1/ New insights into control of #tregs by #DNAmethylation from #SingerLab. #epigenetics @luisamnMD @NMPulmCritCare
Check out our new preprint on @biorxivpreprint: biorxiv.org/cgi/content/sh…
Check out our new preprint on @biorxivpreprint: biorxiv.org/cgi/content/sh…
2/ Treg cells are known to require a lineage-specific DNA hypomethylation pattern during development that stabilizes their lineage. We wanted to determine whether maintenance DNA methylation is required for Treg cell lineage development and stability.
3/ Accordingly, we bred mice with Treg cell-specific deficiency in the epigenetic regulator Uhrf1, which maintains methyl-DNA marks. These mice displayed a profound inflammatory phenotype.
