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Trying my best to understand the results of the very important @RePHILL_trial : Excellent work and fab collaboration studying very complex pts in difficult circumstances #WellDoneAll #Congrats
thelancet.com/journals/lanha…
1/9 on my take….
Result are contradictory to current evidense (RCT and non-RCT) and our understanding of the patophysiology of trauma haemorrhage 2/9 #Limitation #GoAgainstTheFlow #NotRight ?
Trial underpowered ? Power calc reduction 20 - 10 % in PE is a little bold maybe + too many factors affecting the PE. #StatisticalAnalysisPlan reconsidered ?
3/9
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