Discover and read the best of Twitter Threads about #Sotrovimab
Most recents (12)
BREAKING🔔 The 19th paper from G2P-Japan🇯🇵 is out at Lancet Infectious Diseases @TheLancetInfDis . We elucidated the virological characteristics of new SARS-CoV-2 variant of interest, XBB.1.16 (aka #Arcturus) Please RT🔥 1/
thelancet.com/journals/lanin…
thelancet.com/journals/lanin…
XBB.1.16 = XBB.1 + #F486P, #E180V, and #T478K in spike.
cf. XBB.1.5 = XBB.1 + #F486P in spike (i.e., XBB.1.16 = XBB.1.5 + #E180V and #T478K in spike). 2/
cf. XBB.1.5 = XBB.1 + #F486P in spike (i.e., XBB.1.16 = XBB.1.5 + #E180V and #T478K in spike). 2/
A phylogenetic tree shows that XBB.1.16 is a descendant of XBB.1, not of XBB.1.5. 3/
1/x 🧵This Friday at 10:30am, we're excited to announce the reboot of the #forgotten500K campaign with an update from the podcasts hosted by @claremenglish, @MarkOak04974342, @NikolaBrigden. Here's the message for 2023 in advance. RT. 👇
2/x "The #forgotten500K are a group of immunocompromised patients who have not been prioritized during the pandemic and are experiencing higher ongoing levels of risk. The group started off as individuals asking for help while still in isolation during the pandemic.
3/x They were speaking as individuals trying their best to be heard virtually, as they were not able to leave their homes and re-enter normal life like everyone else. However, the #forgotten500K patient campaign brought them together, providing support and one voice. amazing
1/x 🧵***New data *** A double🧦 Lancet headline paper @TheCrick in London from @stcshepherd @TurajlicLab @DavidLVBauer. Results are ASTONISHING about whether we need to protect the #immunocompromised #forgotten500k. thelancet.com/journals/lance… & thelancet.com/journals/lance…. Pls RT.
2/x For those who you don't know. @TheCrick is one of our UK's leading research 👩🔬💪heavy weights with some of the best scientists in the country like @stcshepherd @TurajlicLab @DavidLVBauer. For them to be weighing into the national pandemic landscape is timely & important
3/x. Paper 1⃣ asked the question about cancer patients. They are very #immunocompromised, especially @bloodcancer_uk patients. @stcshepherd @TurajlicLab assessed ~200 cancer patients from their study and looked at immune response to omicron. A study and measure of "protection".
Do mRNA vaccines induce antibody-dependent enhancement (ADE)-causing antibodies also?
We know mRNA vaccines generate robust neutralizing Abs, but vaccines targeting the S-protein, the possible induction of ADE of infection is a concern. 1/
We know mRNA vaccines generate robust neutralizing Abs, but vaccines targeting the S-protein, the possible induction of ADE of infection is a concern. 1/
Recent reports have demonstrated that neutralizing #mAbs against S-protein can exhibit ADE activity in a limited window of Ab concentrations. These reports have demonstrated that some anti-S protein mAbs have the potential to induce ADE of infection. 2/
Several mechanisms leading to #ADE, which can be FcR-dependent but ACE2-independent, FcR-independent but ACE2-dependent, S-protein conformational change-dependent, or both FcR- and ACE2-dependent ADE. 3/
1/ Alla fine è arrivato. Dopo 26 mesi di isolamento, se non per le spese essenziali e passeggiate nei boschi. Un giorno della scorsa settimana il #SARSCoV2 ha raggiunto mio marito. Dopo la mamma 93enne, la badante, e il figlio, sono rimasta indenne solo io.
2/ Mio marito 67enne, oncologico, dializzato a forte rischio è POSITIVO. A riprova che in un mondo senza #mascherine proteggersi dal #COVID è impossibile. Dove si è contagiato non si sa
3/ In #dialisi? Dove tutti indossano maschera ma non è detto la indossino fuori (personale compreso), non è detto la indossino bene, e se convivi per 3 volte a settimana per ore finisce che se c’è un positivo lo prendi. Nasi fuori e finestre chiuse.
USA: BA2 Anteil hat sich verdoppelt
Neue @CDCgov Daten zeigen, dass sich #BA2 von 11,6 % letzte Woche auf 23,1 % verdoppelt hat. Nach unserem Varianten-Modell wird BA2 die Dominanz in den #USA in 2 1/2 Wochen erreichen covid.cdc.gov/covid-data-tra…
Neue @CDCgov Daten zeigen, dass sich #BA2 von 11,6 % letzte Woche auf 23,1 % verdoppelt hat. Nach unserem Varianten-Modell wird BA2 die Dominanz in den #USA in 2 1/2 Wochen erreichen covid.cdc.gov/covid-data-tra…
#USA: BA2121 Anteil steigt über 17% Marke
Follower kennen bereits die Bedeutung der 17% Marke im AITask Varianten-Modell: #BA2121 ist in den #USA auf dem Weg zur Dominanz - trotz #BA2 - und das in neuer Rekordzeit🔴🚑🏥
Follower kennen bereits die Bedeutung der 17% Marke im AITask Varianten-Modell: #BA2121 ist in den #USA auf dem Weg zur Dominanz - trotz #BA2 - und das in neuer Rekordzeit🔴🚑🏥
#USA: Variante BA5 wird dominat
BA5 steht in den USA kurz vor der Dominanz. Wie zuvor modelliert wird #BA5 die Variante #BA2121 ablösen. Die Grafik enthält den Trend der #Modellierung aus 05/2022 und die neusten #Varianten-Daten aus den USA:🦠🌊🚑🏥
covid.cdc.gov/covid-data-tra…
BA5 steht in den USA kurz vor der Dominanz. Wie zuvor modelliert wird #BA5 die Variante #BA2121 ablösen. Die Grafik enthält den Trend der #Modellierung aus 05/2022 und die neusten #Varianten-Daten aus den USA:🦠🌊🚑🏥
covid.cdc.gov/covid-data-tra…
Does #Sotrovimab remain effective against #Omicron sublineage BA.2? Here is another preprint on the issue, this time published by researchers from @Vir_Biotech , the company that produces Sotrovimab and a second, closely related monoclonal antibody. While there is (1/4)
a numerical difference between BA.2 and other variants in a pseudovirus model, the company says that overall, neutralisation activity is sustained in BA.2, which would suggest sustained clinical effectiveness.
-
„Sotrovimab was tested against an extended panel of (2/4)
-
„Sotrovimab was tested against an extended panel of (2/4)
pseudotyped viruses incorporating emerging variants as well as variants currently or previously deemed as Variants of Concern (VOC) or Variants of Interest (VOI) by the World Health Organization (WHO). Sotrovimab neutralized all variants tested with (3/4)
La gente en #Venezuela anda comprando #Molnupiravir y #Remdesivir como si fuera Acetaminofen. Muchas veces sin prescripción médica, solo porque el familiar, el amigo o la vecina se lo recomendo.
Aquí les explico cuál es su uso correcto
🧵
Aquí les explico cuál es su uso correcto
🧵
Tenemos 4 #antivirales disponibles para #COVID19 hasta el momento.
#Paxlovid (Nirmatrelvir/Ritonavir) (oral)
#Sotrovimab (endovenoso)
#Remdesivir (endovenoso)
#Molnupiravir (oral)
De las cuáles, solo tenemos disponibles en Venezuela los 2 últimos.
#Paxlovid (Nirmatrelvir/Ritonavir) (oral)
#Sotrovimab (endovenoso)
#Remdesivir (endovenoso)
#Molnupiravir (oral)
De las cuáles, solo tenemos disponibles en Venezuela los 2 últimos.
¿Cuando usarlos?
Se recomienda el uso de #antivirales orales en pacientes NO hospitalizados con enfermedad leve/moderada (Saturación mayor o igual a 94%) que tienen ALTO RIESGO DE PROGRESIÓN.
Ese riesgo será definido por su médico, pero les voy a aclarar a que se refiere eso.
Se recomienda el uso de #antivirales orales en pacientes NO hospitalizados con enfermedad leve/moderada (Saturación mayor o igual a 94%) que tienen ALTO RIESGO DE PROGRESIÓN.
Ese riesgo será definido por su médico, pero les voy a aclarar a que se refiere eso.
Cos'è il #monoclonare #Sotrovimab?
E' l'unico che sembra funzionare contro #Omicron .
E' ancora in piena sperimentazione, ma se non vi fidate dei #vaccini, perché all'improvviso vi fidate di questo?
Reazioni: oltre alle solite, difficoltà respiratorie e calo pressione
1/2
E' l'unico che sembra funzionare contro #Omicron .
E' ancora in piena sperimentazione, ma se non vi fidate dei #vaccini, perché all'improvviso vi fidate di questo?
Reazioni: oltre alle solite, difficoltà respiratorie e calo pressione
1/2
Quello che è incomprensibile è che il Sotrovimab , in cui c'è una osservazione in atto, si parli di panacea di tutti i mali!
Sui vaccini (che sono preventivi e ormai somministrati a miliardi di individui) c'è pregiudizio incredibile. 2/2
Sui vaccini (che sono preventivi e ormai somministrati a miliardi di individui) c'è pregiudizio incredibile. 2/2
Eppure le reazioni avverse esistono anche per il monoclonale. Tra l'altro è anche una procedura molto costosa e non ci sono moltissime disponibilità.
Non "curano gli eletti", ma al momento non è per tutti, occorrono delle caratteristiche ben precise per la somministrazione.
Non "curano gli eletti", ma al momento non è per tutti, occorrono delle caratteristiche ben precise per la somministrazione.
With #Omicron rapidly spreading nationwide, I am concerned about all the members of our communities with damage and injury in the immune system, particularly to cell-mediated injury (to T cells and Ab-producing cells). In neutralization studies, most monoclonal Abs used to date
2/ have lost activity to #Omicron and are no longer useful in areas with high attack rates (pretty much everywhere in US right now). There are two possible exceptions. The first is #sotrovimab which was originally isolated from an individual with
3/ #SARSCoV1 (not a typo) back in 2003. The Ab recognizes a conserved glycan motif at the base of the Spike protein (away from the ACE-2 receptor-binding domain). Extremely limited supplies and fairly narrow emergency use authorization, as follows:
-🛑-Modifications du registre #AIFA (agence Italienne de pharmacologie) 🇮🇹
aifa.gov.it/-/modifiche-re…
- anticorps monoclonaux #COVID19
bfmtv.com/sante/covid-19…
A partir du 07/08/2021 il est égalnt possible d'utiliser l'anticorps monoclonal #sotrovimab contre le #COVID19 :
-THREAD
aifa.gov.it/-/modifiche-re…
- anticorps monoclonaux #COVID19
bfmtv.com/sante/covid-19…
A partir du 07/08/2021 il est égalnt possible d'utiliser l'anticorps monoclonal #sotrovimab contre le #COVID19 :
-THREAD
-Que sont les anticorps monoclonaux ?
Sources bfm afin d'atteindre le maximum de 🧠, enfin ce qu'il en reste.
Nous informons les utilisateurs des Registres des médicaments sous surveillance que, suite à la publication de la Détermination AIFA n.911 dans le Journal Officiel n.187
Sources bfm afin d'atteindre le maximum de 🧠, enfin ce qu'il en reste.
Nous informons les utilisateurs des Registres des médicaments sous surveillance que, suite à la publication de la Détermination AIFA n.911 dans le Journal Officiel n.187
du 06.08.2021, à partir du 07/08/2021 il est possible d'utiliser également l'anticorps monoclonal sotrovimab, pour l'indication thérapeutique suivante :
"Traitement de la maladie à coronavirus 2019 (COVID-19) légère ou modérée chez les adultes et les adolescents âgés de 12 ans
"Traitement de la maladie à coronavirus 2019 (COVID-19) légère ou modérée chez les adultes et les adolescents âgés de 12 ans
#EUCommission to buy over 200,000 COVID anti-body treatments | 15:52
- #Sotrovimab, developed by #GlaxoSmithKline in collaboration with VIR biotechnology, is part of the first portfolio of five COVID-19 therapeutics announced by the Commission in June 2021
euractiv.com/section/corona…
- #Sotrovimab, developed by #GlaxoSmithKline in collaboration with VIR biotechnology, is part of the first portfolio of five COVID-19 therapeutics announced by the Commission in June 2021
euractiv.com/section/corona…
Covid-19: Patients vouch for effectiveness of #Sotrovimab | Jul 24
- Patients treated with Sotrovimab, the new #Covid19medicine, praised the effectiveness of the drug to reduce symptoms in a matter of days.
khaleejtimes.com/coronavirus-pa…
- Patients treated with Sotrovimab, the new #Covid19medicine, praised the effectiveness of the drug to reduce symptoms in a matter of days.
khaleejtimes.com/coronavirus-pa…
#Sotrovimab is an investigational human neutralizing dual-action #monoclonalantibody with activity against severe acute respiratory syndrome coronavirus 2, known as #SARSCoV2.
- Sotrovimab is designed to attach to the spike protein of SARS-CoV-2.
en.wikipedia.org/wiki/Sotrovimab
- Sotrovimab is designed to attach to the spike protein of SARS-CoV-2.
en.wikipedia.org/wiki/Sotrovimab
