Discover and read the best of Twitter Threads about #Sulzer_Lab

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#Autism is often associated with an excess of synapses:
but how does this trait affect large-scale circuit function?

Here's what we found by modelling autism-related pruning deficits across-species🧠🐭

By @MarcoPagani1985 @mvlombardo & al.

Thread 1/n
Postmortem investigations in idiopathic #Autism have consistently revealed an excess of excitatory synapses

Seminal work form the #Sulzer_Lab @Columbia has shown that postmortem synaptic surplus in #Autism is associated with hyperactive mTOR signalling
➡️this is a molecular pathway often dysregulated in autism and a key point of convergence of many autism-risk genes

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