Discover and read the best of Twitter Threads about #Superantigens
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as I keep saying tweeps
and govts want us to remove our masks!
(this is several months old now, but still holds even more true)
and govts want us to remove our masks!
(this is several months old now, but still holds even more true)
let's talk about #CytokineStorm in #COVID19.
1st, there is no standard threshold above which something is called #CytokineStorm.
Mechanistically, the simplest form of #CytokineStorm we can understand is when anti-CD19 #CART cells are infused in tumor-bearing recipients.
1st, there is no standard threshold above which something is called #CytokineStorm.
Mechanistically, the simplest form of #CytokineStorm we can understand is when anti-CD19 #CART cells are infused in tumor-bearing recipients.
in this scenario, we have large numbers of antigen-specific T cells (anti-CD19) and large numbers of antigen-bearing cells (CD19+ tumor cells). When too many T cells engage with too many antigens simultaneously in a short period of time we get #CytokineStorm
Why is that? This is because naturally developing an adaptive immune system (T cells) ordinarily doesn't work that way. 1st, for a given antigen we have very few antigen-specific T cells (~ 50 cells/antigen, unlike anti-CD19 CAR-T cells that are in millions).
