Discover and read the best of Twitter Threads about #TATAbox
Most recents (1)
What's the deal with ... Gilbert's syndrome?
Unconjugated bilirubin deserves its own #tweetorial
Featuring:
🟨Why?
🟨Is it bad or...PLOT TWIST...good!?
🟨What to do about it?
🏆The most 🍌🍌trials ever conducted
#livertwitter #meded #MedTwitter
1/
Unconjugated bilirubin deserves its own #tweetorial
Featuring:
🟨Why?
🟨Is it bad or...PLOT TWIST...good!?
🟨What to do about it?
🏆The most 🍌🍌trials ever conducted
#livertwitter #meded #MedTwitter
1/
What is Gilbert's?
1⃣Healthy person gets labs. Bili 2.4, >80% indirect
2⃣Student studies all🌙, forgets 2 eat.
In AM,👀slightly 🟨
Turns out:
👉3% of🌎has bili>1.4mg/dL (fig1)
Many things⬆️indirect bili:
👉Only 1⃣ makes bili⬆️w/fasting (Fig2)
It's...
2/
1⃣Healthy person gets labs. Bili 2.4, >80% indirect
2⃣Student studies all🌙, forgets 2 eat.
In AM,👀slightly 🟨
Turns out:
👉3% of🌎has bili>1.4mg/dL (fig1)
Many things⬆️indirect bili:
👉Only 1⃣ makes bili⬆️w/fasting (Fig2)
It's...
2/
GILBERT'S SYNDROME
Who?1⃣Described c1901. Hilarious paper
(🙏google translate, my🇨🇦franglish education)
Why?2⃣Familial⬇️UDPGT protein
(the thing that 'conjugates' bili)
Why?3⃣Base pair insertion in UGT1A1 promoter
(#TATAbox, the gene that makes UDPGT)
3/
Who?1⃣Described c1901. Hilarious paper
(🙏google translate, my🇨🇦franglish education)
Why?2⃣Familial⬇️UDPGT protein
(the thing that 'conjugates' bili)
Why?3⃣Base pair insertion in UGT1A1 promoter
(#TATAbox, the gene that makes UDPGT)
3/
