Discover and read the best of Twitter Threads about #TMPRSS2
Most recents (5)
Key findings on #Omicron’s characteristics:
1-Omicron spike binds ACE2 better than Delta.
2-Both Omicron & Delta replicate similarly in nasal cell cultures
3-However, in airway cells high in TMPRSS2 there was significant impairment for Omicron. 1/
1-Omicron spike binds ACE2 better than Delta.
2-Both Omicron & Delta replicate similarly in nasal cell cultures
3-However, in airway cells high in TMPRSS2 there was significant impairment for Omicron. 1/
4-Omicron has altered preference for cell entry towards a TMPRSS2 *independent* pathway that involves engulfing of virus by endocytosis rather than fusion of the virus with the cell directly (TMPRSS2 *dependent*). 2/ 
5-Consistent with impaired use of #TMPRSS2, the Omicron spike was inefficiently cleaved
This came as a surprise because Omicron has 3 mutations around the polybasic cleavage site (S1/S2). 3/
This came as a surprise because Omicron has 3 mutations around the polybasic cleavage site (S1/S2). 3/
Comparison of SARS-CoV-2 Receptors Expression in Primary Endothelial Cells and Retinoic Acid-Differentiated Human Neuronal Cells
#TMPRSS2 #NRP1 #ACE2 levels increase when cells are treated with #retinoicacid (RA).
#ACE2 and #TMPRSS2 expression in subsets of lung epithelial cells
#TMPRSS2 #NRP1 #ACE2 levels increase when cells are treated with #retinoicacid (RA).
#ACE2 and #TMPRSS2 expression in subsets of lung epithelial cells
are regulated by androgen-signaling. #NRP1 is highly expressed in the respiratory and olfactory epithelium, which can explain the SC2 infectivity and spreading through both the lungs and olfactory bulb. NRP1 is involved in axonal guidance and pruning. Data indicate that
pseudoviral entry is aligned with the expression of NRP1 levels. This seems to substantiate the previous observations showing that NRP1 plays a major role for SARS-CoV-2 entry in certain cell types. Here, the study demonstrated higher expression of both NRP1 and TMPRSS2,
1/
🔥EXCELLENT results for Phase III multicentric double-blind RCT of #proxalutamide for hospitalized #COVID_19 patients🔥
n=588
Study led by @FlavioCadegiani in 🇧🇷
92% reduction in mortality ! prnewswire.com/news-releases/…
🔥EXCELLENT results for Phase III multicentric double-blind RCT of #proxalutamide for hospitalized #COVID_19 patients🔥
n=588
Study led by @FlavioCadegiani in 🇧🇷
92% reduction in mortality ! prnewswire.com/news-releases/…
2/
Keep in mind that this is a press release, not a scientific publication.
A point is particularly unclear in the press release, i.e. authors claim 588 patients were enrolled, but then later write they were 294 in proxalutamide group & 296 in control group.
294+296=590≠588.
Keep in mind that this is a press release, not a scientific publication.
A point is particularly unclear in the press release, i.e. authors claim 588 patients were enrolled, but then later write they were 294 in proxalutamide group & 296 in control group.
294+296=590≠588.
3/
Detailed results were shared in Portuguese during this press conference in 🇧🇷
Detailed results were shared in Portuguese during this press conference in 🇧🇷
Infektionsgefahr in #Schulen über belastete #Aerosole
Professor #Kähler schließt sich der #AITAsk Bewertung an:
"#Lüften alleine reicht nicht. Die Schulen wurden ja lange zugemacht, weil es eben nicht reicht". #twlz #kmk #rki
sueddeutsche.de/muenchen/landk…
Professor #Kähler schließt sich der #AITAsk Bewertung an:
"#Lüften alleine reicht nicht. Die Schulen wurden ja lange zugemacht, weil es eben nicht reicht". #twlz #kmk #rki
sueddeutsche.de/muenchen/landk…
Schulen sind mittlerweile wieder geöffnet, weitere Jahrgänge sollen folgen, dabei steigen bundesweit die Infektionszahlen. Gleichzeitig breitet sich die Mutante #B117 weiter aus. #Schulen sollen "eher" keine Pandemie-Treiber und dank #AHA+L sicher sein, sagt das #RKI. Stimmt das?
Eine erste Warnung, was ein #Superspreader im #Klassenzimmer bewirken kann und warum #Schulen sehr schnell zu einem Pandemie-Treiber werden können, zeigte das Ergebnis der #AITask-#Modellierung bereits im August 2020: Superspreader Klassenzimmer #twlz #kmk
MEDICAMENTOS PARA #COVID19
Desde diciembre 2019 que se reportó el primer caso de infección por #SARS_CoV_2, han surgido un sinfín de tratamientos para esta infección.
¿Pero cual tiene suficiente evidencia científica?
Abro hilo
Desde diciembre 2019 que se reportó el primer caso de infección por #SARS_CoV_2, han surgido un sinfín de tratamientos para esta infección.
¿Pero cual tiene suficiente evidencia científica?
Abro hilo
Empecemos por dejar en claro varios puntos:
•#COVID19: Enfermedad provocada por la infección #SARSCoV2.
•#SARSCoV2: Nuevo tipo de #coronavirus que por sus siglas en inglés se refiere a 𝘴𝘦𝘷𝘦𝘳𝘦 𝘢𝘤𝘶𝘵𝘦 𝘳𝘦𝘴𝘱𝘪𝘳𝘢𝘵𝘰𝘳𝘺 𝘴𝘺𝘯𝘥𝘳𝘰𝘮𝘦 𝘤𝘰𝘳𝘰𝘯𝘢𝘷𝘪𝘳𝘶𝘴 𝟸
•#COVID19: Enfermedad provocada por la infección #SARSCoV2.
•#SARSCoV2: Nuevo tipo de #coronavirus que por sus siglas en inglés se refiere a 𝘴𝘦𝘷𝘦𝘳𝘦 𝘢𝘤𝘶𝘵𝘦 𝘳𝘦𝘴𝘱𝘪𝘳𝘢𝘵𝘰𝘳𝘺 𝘴𝘺𝘯𝘥𝘳𝘰𝘮𝘦 𝘤𝘰𝘳𝘰𝘯𝘢𝘷𝘪𝘳𝘶𝘴 𝟸
Es decir, puedes tener la infección pero no desarrollar la enfermedad.
Esto es importante para entender la clasificación los @NIH para la infección por #SARSCoV2:
1.- Asintomático
2.- Cuadro leve
3.- Cuadro moderado
4.- Cuadro severo
5.- Cuadro criticó
covid19treatmentguidelines.nih.gov/whats-new/
Esto es importante para entender la clasificación los @NIH para la infección por #SARSCoV2:
1.- Asintomático
2.- Cuadro leve
3.- Cuadro moderado
4.- Cuadro severo
5.- Cuadro criticó
covid19treatmentguidelines.nih.gov/whats-new/
