Discover and read the best of Twitter Threads about #TPOXX

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“What is the treatment for monkeypox? How does it work?”

Here I give a short overview of how the drug Tecovirimat (TPOXX) works for the treatment of smallpox / monkeypox / or other vaccinia virus type infections. TPOXX can be administered by IV injection or as an oral pill.
In the US, TPOXX is FDA approved for the treatment of smallpox disease for adults and children and is currently in the Strategic National Stockpile. Its use for other orthopox virus infections, including monkeypox, is under an Expanded Access Investigational New Drug protocol.
This allows for the use of tecovirimat (#TPOXX) for primary or early empiric treatment of non-smallpox infections (such as monkeypox) in adults and children of all ages [in the US].
Read 5 tweets
The California Senate Select Committee hearing on #monkeypox is about to begin. Stay tuned for updates/livetweets
@Scott_Wiener says "severe public health failures" over the years have led to the outbreak we are experiencing now, citing expiration of the national vaccine stockpile
Wiener says it needs to be acknowledged that the virus is "overwhelmingly" impacting gay and bisexual men without stigmatizing them, and that there is no guarantee that the virus doesn't spread further
Read 23 tweets
Last month, many of us @mgh_id @bwh_id @BIDMC_IDFellows + @MassDPH came together to care for 3 patients with #monkeypox in Massachusetts and used #tecovirimat for the first time in the state. I'm excited to share our experience in @OFIDJournal.

A brief 🧵…
Key takeaways:

▶️ #tecovirimat was well-tolerated
▶️ our patients (acknowledging limitations of a 3-patient observational study) felt it improved their symptoms and paused progression of early lesions
▶️ the process of obtaining and using #Tpoxx was unnecessarily cumbersome
As #monkeypox cases increase, @US_FDA and @CDCgov should urgently make #tecovirimat readily accessible, and we should leverage lessons from #COVID19 to expedite clinical trials that establish safety, efficacy and inform delivery.

How to obtain #Tpoxx:…
Read 6 tweets
.@CDCgov's latest COCA update on #monkeypox epidemiology, testing, vaccination & treatment. Now 3591 cases in US. 99% male at birth (possibly some trans women), 13 people female at birth (includes some trans men). All but 5 cases attributed to sex between men. 1/
These COCA updates provide a wealth of info. This one includes testing update (now capacity of 80K tests per week, but still only lesion swabs), revised simpler protocol for #TPOXX treatment. 2/…
I've seen some comments on trans reporting. It doesn't say so on this slide, but @CDCgov previously reported there were no trans women & "some" trans men among monkeypox cases to date. @SF_DPH, which is more clued in on this, reports the same.
Read 4 tweets

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