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Excited to share our recent @SwantonLab @NickyMcGranahan & @MariamJHanjani lab work on the genomic evolution of non-small cell lung cancer metastases in #TRACERx, out @Nature
nature.com/articles/s4158…
A quick thread [1/13]
nature.com/articles/s4158…
A quick thread [1/13]
We analysed paired primary-metastasis data from 126 patients (218 metastatic & 476 primary tumour samples) within the first 421 patients recruited to TRACERx. We explored the timing of metastatic divergence, modes of metastatic dissemination and selection in seeding clones [2/13]
We reconstructed primary tumour phylogenies & timed metastatic divergence relative to the trunk. Divergence is when the metastatic clone first existed & differs from time of spread. The majority of cases (94/126) diverged late following a clonal sweep in the primary tumour [3/13]
