Discover and read the best of Twitter Threads about #TheAcidTest
Most recents (16)
Andrea affected at 22 after mild infection (maybe EBV)
Extreme progression after a few months
Today fully bedbound
Extreme progression after a few months
Today fully bedbound
17 year old case study they published in 2022
"When a 17-year old girl is diagnosed..."
Girl had diary showing how severe Sx, which they plotted and showed fluctuations over many different time scales.
"When a 17-year old girl is diagnosed..."
Girl had diary showing how severe Sx, which they plotted and showed fluctuations over many different time scales.
Gets samples from the clinic (Haukeland University Hospitals) from RituxME and CycloME clinical trials
Did metabolomics on the samples
Did metabolomics on the samples
Energy metabolism
main energy pathway under aerobic conditions
glucose ->pyruvate->Acetyl-CoA goes into Kreb cycle
(dependent on presence of oxygen)
main energy pathway under aerobic conditions
glucose ->pyruvate->Acetyl-CoA goes into Kreb cycle
(dependent on presence of oxygen)
Prof Karl J Tronstad - energy metabolism and associations to clinical data in ME
There is no unified hypothesis that everyone agrees on, but there are observations that are guiding research
Mechanism, treatments and biomarkers of #MECFS - investigating abnormalities in the clinic, biobank and lab
A warning to anyone thinking of trying the low PRAL diet: if you’re not in a state of acidosis, it could push you into alkalosis, which you also don’t want to be in.
So please be cautious, a diet may not sound too risky, but these diets do real things in the body #TheAcidTest
So please be cautious, a diet may not sound too risky, but these diets do real things in the body #TheAcidTest
Personally the low PRAL diet won’t be something I will try.
My lactic acid levels are elevated, yes, but that does not mean acidosis.
Typically between 2-4mmol/l are not indicative of lactic acidosis unless blood pH is also acidic patient.info/doctor/lactic-…
My lactic acid levels are elevated, yes, but that does not mean acidosis.
Typically between 2-4mmol/l are not indicative of lactic acidosis unless blood pH is also acidic patient.info/doctor/lactic-…
Levels of lactate between 2-4mmol/L may even be beneficial: “Lactate itself is not toxic or harmful & there is some evidence that Hyperlactatemia may be beneficial in some conditions, e.g traumatic brain injury & severe hypoglycaemia…as a metabolic fuel” ep.bmj.com/content/106/3/…
🍭 Candy Girl 🍭
SARS2 spike protein binds to Glucose Regulated Protein 78 (GRP78) just like Pep42 of cancer cells does. >
researchsquare.com/article/rs-151…
SARS2 spike protein binds to Glucose Regulated Protein 78 (GRP78) just like Pep42 of cancer cells does. >
researchsquare.com/article/rs-151…
Diabetics with dysregulated sugars did not fare well, haha, this image. 😀 >
>
So, we have an answer and a diagnosis!
Mitochondrial Dysfunction!
Not disaster bad, but it does explains all my symptoms!
Reference block is 0,2-0,7 (mine 0,158)
Reference post block 0,3-0,8 (mine 0,19)
Thank you for NOTHING, dear (private) doctors in the past 2 1/2 years!
Mitochondrial Dysfunction!
Not disaster bad, but it does explains all my symptoms!
Reference block is 0,2-0,7 (mine 0,158)
Reference post block 0,3-0,8 (mine 0,19)
Thank you for NOTHING, dear (private) doctors in the past 2 1/2 years!
Seriously, I work I retail and have NO medical education!
How the hell is possible, NO ONE was ever checking this until I asked for those tests?????
Explains really nice, why ALA & glutathione are helping! Explains really nice, why low carb is helping! Explains really good, why
How the hell is possible, NO ONE was ever checking this until I asked for those tests?????
Explains really nice, why ALA & glutathione are helping! Explains really nice, why low carb is helping! Explains really good, why
In my case exercise is helping and why stress is worsening everything!
I am really p***ed, no one looked at it, even YOU CAN GOOGLE THE SYMPTOMS AND IT TURNS OUT ITS MITOCHONDRIAL 😤
Thanks to twitter & #TheAcidTest ❤️
I am really p***ed, no one looked at it, even YOU CAN GOOGLE THE SYMPTOMS AND IT TURNS OUT ITS MITOCHONDRIAL 😤
Thanks to twitter & #TheAcidTest ❤️
PI% info @PanickedFoodie @tessfalor
I’m always hot after I eat my evening meal so decided to check my PI and yep, best I’ve ever seen it (usually under 1.5)! Supports eating causing improved blood flow. But…my SPO2 is the lowest I’ve ever seen it. Never seen it go below 98%
I’m always hot after I eat my evening meal so decided to check my PI and yep, best I’ve ever seen it (usually under 1.5)! Supports eating causing improved blood flow. But…my SPO2 is the lowest I’ve ever seen it. Never seen it go below 98%
Only other times I’ve managed to improve my PI% have been my using a hot water bottle on my abdomen (but it only went from 1.5% to 5.7%), or by laying down in bed & heating myself with a hair dryer, where my PI% went over 15% for the first time.
And I’ve been resting different fingers: each finger has different values but my left hand has consistently lower perfusion than my right, which ties in with blood tests where they can never find a good vein on the left!
#TheAcidTest @theacidtesters
@angryhacademic
@Naomi_D_Harvey @CiaraGlenville @Aguirre1Gustavo
DAY 6
Yesterday was busy. Drive to appt, Physio, food shop, heated exchange with himself over 💶 =ANS flare. Dizziness, nausea, weakness. Felt like someone clubbed the bk of my head...
@angryhacademic
@Naomi_D_Harvey @CiaraGlenville @Aguirre1Gustavo
DAY 6
Yesterday was busy. Drive to appt, Physio, food shop, heated exchange with himself over 💶 =ANS flare. Dizziness, nausea, weakness. Felt like someone clubbed the bk of my head...
Today post ANS woke up nauseous, full body pain and head pressure/ache. Body sore & stiff.
DAY 6
On waking (fasted)
SPo2 99%
HR:87bpm
GLU : 7.6mmol/L (⬆️ 5.5 yesterday)
LAC : 3.5mmol/L (⬆️ 2.6 yesterday)
1hr post Earl grey, honey spelt x 2 + butter, kefir 150g.
LAC 3.9mmol/L
DAY 6
On waking (fasted)
SPo2 99%
HR:87bpm
GLU : 7.6mmol/L (⬆️ 5.5 yesterday)
LAC : 3.5mmol/L (⬆️ 2.6 yesterday)
1hr post Earl grey, honey spelt x 2 + butter, kefir 150g.
LAC 3.9mmol/L
So then I got curious. Still have some LAC test strips exp tmrw. Repeated post meal LAC readings at 0min (index finger), 4 min (middle finger) & 14 min (ring finger). Same lancet used x 3 readings
Post meal LAC in mmol/L
(0min) 9.35am=3.9
(4min) 9.39am =2.8
(14min) 9.46am = 4.4
Post meal LAC in mmol/L
(0min) 9.35am=3.9
(4min) 9.39am =2.8
(14min) 9.46am = 4.4
went to the store for a new experiment
I am finally going to post some thoughts on ALA supplementation now that I've been taking it for a couple weeks! it is definitely one of the more interesting supplements I've ever tried. it has both positive and negative effects, but I'm settling on a dose that helps overall
the main effect I notice is that it 'activates' my skeletal muscles - releases them from spasm and allows me to consciously tense/release them - and it feels like more blood is getting into my tissue. it moistens my dry eyes, my skin is warmer (but without niacin-type flushing)
Important for those with #LongCovid & #MECFS testing their lactate (#TheAcidTest):
The Edge recently started providing supplemental information with their meters.
It reads:
"The most common reason for inaccurate results is using a blood drop size that is too small. 👇
The Edge recently started providing supplemental information with their meters.
It reads:
"The most common reason for inaccurate results is using a blood drop size that is too small. 👇
You should have enough blood to QUICKLY and COMPLETELY fill the test window, ideally with a little to spare.
Some people choose to perform back-to-back tests to test the meter itself for consistency. If you are doing so, it is CRITICAL to perform both tests within a minute..
Some people choose to perform back-to-back tests to test the meter itself for consistency. If you are doing so, it is CRITICAL to perform both tests within a minute..
or two of each other and use SEPERATE puncture locations for each test."
Are you wondering what the trending hashtag #TheAcidTest is?
#TheAcidTest is a worldwide patient-led #LongCovid #MECFS #VaccineInjured project using at-home devices, like GlucoRx & Edge, to measure lactate at waking & 1 hr after breakfast
Story in 🧵
#TheAcidTest is a worldwide patient-led #LongCovid #MECFS #VaccineInjured project using at-home devices, like GlucoRx & Edge, to measure lactate at waking & 1 hr after breakfast
Story in 🧵
@Vickyvdtogt, a #LongCovid patient, did self-experimentation, found out she had high lactate, wrote a hypothesis paper, & published it!
frontiersin.org/articles/10.33…
#TheAcidTest
frontiersin.org/articles/10.33…
#TheAcidTest
Basic thread about fingertip blood sampling for lactate levels 🧵#TheAcidTest
Lactic acid is a key molecule, part of our anaerobic fermentation, which is one way for cells to obtain energy (=ATP⚡).
Advantages:
1. Anaerobic metabolism means it doesn't need oxygen to work.
...
Lactic acid is a key molecule, part of our anaerobic fermentation, which is one way for cells to obtain energy (=ATP⚡).
Advantages:
1. Anaerobic metabolism means it doesn't need oxygen to work.
...
2. Lactate can go back to pyruvate->glucose (Cori cycle) to be included in the mitochondrial respiratory chain (using oxygen)
Disadvantage: anaerobic is much less efficient than the aerobic respiratory chain
➡️When we measure lactate we're usually interested in two things:
Disadvantage: anaerobic is much less efficient than the aerobic respiratory chain
➡️When we measure lactate we're usually interested in two things:
1- Lactate elevation due to tissue hypoperfusion:
It can be caused by complete occlusion of a large vessel followed by reperfusion, which releases lactate back into circulation.
Small vessel occlusions or capillary dysfunction may also lead to high lactate released in venules.
It can be caused by complete occlusion of a large vessel followed by reperfusion, which releases lactate back into circulation.
Small vessel occlusions or capillary dysfunction may also lead to high lactate released in venules.
#TheAcidTest - Day 1.0
Using my @GlucoRx X6 Meter AKA 'The Thingy'
On waking (after 14 hrs fast) - Lactate=1.6 mmol/L
PulseOx 97% RHR 59
Visible App Score=4
Garmin 'Connect' sleep score=51
Subjective Feeling Like Death Index: 4/10 (0=Dead)
Using my @GlucoRx X6 Meter AKA 'The Thingy'
On waking (after 14 hrs fast) - Lactate=1.6 mmol/L
PulseOx 97% RHR 59
Visible App Score=4
Garmin 'Connect' sleep score=51
Subjective Feeling Like Death Index: 4/10 (0=Dead)
#TheAcidTest - Day 1.1
One hour after 'breakfast' - Lactate= 2.8 mmol/L
(Never really do breakfast apart from pints of tea and some fruit)
PulseOx 98% RHR 69
One hour after 'breakfast' - Lactate= 2.8 mmol/L
(Never really do breakfast apart from pints of tea and some fruit)
PulseOx 98% RHR 69
#TheAcidTest - Day 1.2
One hour after lunch - Lactate=1.3 mmol/L
Blood Glucose= 7.6 mmol/L
PulseOx 98% RHR 81
One hour after dinner - Lactate= 5.1 (!) mmol/L
PulseOx 99% 69RHR
One hour after lunch - Lactate=1.3 mmol/L
Blood Glucose= 7.6 mmol/L
PulseOx 98% RHR 81
One hour after dinner - Lactate= 5.1 (!) mmol/L
PulseOx 99% 69RHR
The AXA1125 mimic I am taking: would like to help if others want to make it and can’t find info in sprawling tweets/ threads. Info here on how to make it, and a nice explainer video with reference to reduced lactate levels with AXA1125 too! 📣 #TheAcidTest
Original dosage from this paper: journals.lww.com/ajg/Fulltext/2…
And study in long Covid at 6 sachets per day in this: thelancet.com/journals/eclin…
And study in long Covid at 6 sachets per day in this: thelancet.com/journals/eclin…
Great explainer video here (with thanks to @Michaeltikus!). Note that also increasing blood volume is another mode of action I suspect
#TheAcidTest 📣 Guide for at home lactate testing #pwME #LongCovid #vaccineinjured ! Please note your results, questionnaire to follow. If interested in US bulk buy/device sharing please DM @ales_frost
Please use #TheAcidTest if tweeting results. Join in! forms.gle/sDBr2BG8udKG4J…
Please use #TheAcidTest if tweeting results. Join in! forms.gle/sDBr2BG8udKG4J…
UK device and *Ireland* device (this does ship to Ireland!) glucorx.co.uk/shop/glucorx-x…
Only £20 plus shipping. Added lactate strips currently free as due to expire on 24th May 23
Only £20 plus shipping. Added lactate strips currently free as due to expire on 24th May 23
And now a word from those behind the climate strikes. The We Mean Business co-founders et al. They thank you, for without you, there is no saving the ruling classes & the suicidal system killing us.
Let's take a look.
1st up-The co-founder of We Mean Business liked this one
Let's take a look.
1st up-The co-founder of We Mean Business liked this one
If you are not caught up with We Mean Business, you may find Volume II ACT V worth your time:
wrongkindofgreen.org/2019/09/18/the…
#TheyMeanBusiness
wrongkindofgreen.org/2019/09/18/the…
#TheyMeanBusiness
Here is another that Grieve appears to like.
Greta: "We don't want to be heard."
I wonder what adult taught @GretaThunberg to hate democracy? Wall Street wants to heard - as does We Mean Business et al. (And today sadly they were).
Greta: "We don't want to be heard."
I wonder what adult taught @GretaThunberg to hate democracy? Wall Street wants to heard - as does We Mean Business et al. (And today sadly they were).
