Discover and read the best of Twitter Threads about #TherapeuticIndex
Most recents (1)
NEW #DTAT paper: What Were They Thinking? Pharmacologic priors implicit in a choice of 3+3 dose-escalation design arxiv.org/abs/2012.05301
“The unexamined trial is not worth conducting.”
— Socrates 1/
“The unexamined trial is not worth conducting.”
— Socrates 1/
This latest #DTAT paper @arxiv sets out to reverse-engineer the unstated (∴ unexamined!) pharmacologic intuitions that underlie the #trialsafety claim implicit in the decision to conduct a dose-escalation trial. 2/ 
Prior elicitation from doctors has never been easy, especially about #pharmacology or the future of the #Daleks: 3/
