Discover and read the best of Twitter Threads about #Thiamine
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Someone DM'd me about POTS and long-Covid and asked if a ketogenic diet could help. So let's do a quick little thread. 🧵1/7
I wrote an article about how #Keto can help with neuro #Covid symptoms, but it is mostly focused on cognitive and mood symptoms, not POTS. Here it is if anyone is interested. 2/7
mentalhealthketo.com/2022/10/01/bes…
mentalhealthketo.com/2022/10/01/bes…
That said, the mechanisms can be similar. For example, #neuroinflammation (which keto is great for) impairs the function of the #Vagus nerve, which is implicated in POTS symptoms. 3/7
Key: "The observed pulmonary vascular dilation might be due to relative failure of normal, physiological hypoxic pulmonary vasoconstriction in the setting of overactivation of a regional vasodilatation cascade as part of a dysfunctional and diffuse inflammatory process." 2/
This leads me to hypothesize this is the site of viral injury, where #COVID binds #ACE2R's - where mito demands are the greatest - where #HIF proteins and assoc. cascades they initiate are in play - including #vasodialiation #angiogenesis and excessive #inflammation 3/
I want to talk about 2 papers that highlight the role of mitochondria in what are likely the progression of symptoms assoc with #COVID19. Note these papers are not about #covid but highlight important pathways. 1/
1st paper - Intracellular ATP is req. 4 #mitochondrial #apoptotic pathways rat #cardiac #myocytes ncbi.nlm.nih.gov/pubmed/12909326 2/
Key findings: apoptosis and necrosis are part of the same pathway, initiated by same mito sequences but are distinguished by time and severity, where the delimiting factor is available intracellular #ATP. 3/
