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Just read 2012 review @NatureRevGenet pubmed.ncbi.nlm.nih.gov/22641018/
DNA methylation has instructive role in initiating or reinforcing silencing ?? Open question !!
#NotDNAmExpert, my take, DNAm reinforces silencing. Please share your thoughts.
DNA methylation has instructive role in initiating or reinforcing silencing ?? Open question !!
#NotDNAmExpert, my take, DNAm reinforces silencing. Please share your thoughts.
#DNAm of the Hprt gene on the inactive X chromosome occurred after the chromosome had been inactivated. In other words, #DNAm appeared to serve as a ‘lock’ to reinforce a previously silenced state of X-linked genes. @CellCellPress pubmed.ncbi.nlm.nih.gov/3791414/
In cancer cells, genes with CGI promoters that are already silenced by Polycomb are more likely than other genes to become DNAm in cancer: that is, the silent state precedes methylation. #TooManyRefsForThis
