Discover and read the best of Twitter Threads about #Tregs
Most recents (6)
Excited to share our new paper out at @NatImmunol today! We discovered the limiting factor for #brain #Tregs is #IL2, and developed a new #genetherapy to treat #traumaticbraininjury and other #neuroinflammatory pathologies. 1/12
nature.com/articles/s4159…
nature.com/articles/s4159…
The work started more than 10 years ago, after my brother Russell died following a #traumaticbraininjury. The more I read into it, the more treatable #neuroinflammation seems. Obviously there is a #brain delivery problem, but stopping #inflammation is basic #immunology! 2/12 
We had a great post-doc, @EmanuelaPasciu1, drive a project showing #Tcells in mouse and human brain, with key functions. Among these T cells were a small population of anti-inflammatory #Tregs, again in mouse and human. 3/12
cell.com/cell/fulltext/…
cell.com/cell/fulltext/…
Recently, we published the concluding part III of the #SPIRAL model, which we were working on since 2016.
Pathological T Helper Polarization Requires Pre-existing Cross-Reactive Memory T Cells
I'm going to explain the significance of this model.
preprints.org/manuscript/202…
Pathological T Helper Polarization Requires Pre-existing Cross-Reactive Memory T Cells
I'm going to explain the significance of this model.
preprints.org/manuscript/202…
In part I published in 2018, we introduced the SPIRAL model. It proposes that cross-reactivity is the basic unit that drives the evolution of adaptive immune system and it is thymus-derived regulatory T cells, Tregs, that rely on cross-reactive epitopes to control other T cells
We also proposed that thymus-derived #Foxp3 Tregs rely on #CrossReactive epitope derived from the friendly gut microbiota to survive and function in the periphery. So one of the main roles of gut microflora is to supply #Tregs with epitopes.
onlinelibrary.wiley.com/doi/10.1111/sj…
onlinelibrary.wiley.com/doi/10.1111/sj…
I am the luckiest person in the world to have such wonderful trainees who organized the most amazing #IwasakiLabReunion/birthday zoom party yesterday. I am still in awe of how incredibly inspiring it was. Here are a few highlights I want to share with you. (1/)
The event started with a delicious lunch delivered to my door for me and my family, to be followed later by my favorite dinner 🍣and 🎂 🍾 🎁 in the evening 😋 They really know how to spoil me! The entire day was packed with amazing talks, trivia sessions and Prince songs 💜(2/)
So 🙏🏼 to everyone who organized this incredible reunion and thoughtful presents - @maria_tokuyama @MelissaLV14 Kris Sepanek @jofrank1088 @JeffGehlhausen @Myoungjoo @peowenlu @carolilucas @aliceluculligan @tianyangmao @annsea_park @marioph13 @taka_takehiro @YYexin Pat Wong (3/)
Meet Kevin Hendrawan, the PhD Student from the @SVH_BSCCR lab at St Vincent's Centre for Applied Medical Research @UNSW, the researcher helping us understand how people with #multiplesclerosis may benefit from stem cell transplantation
A thread 👇
#stemcells #transplant #Tregs
A thread 👇
#stemcells #transplant #Tregs
While our immune system is important for eliminating harmful foreign molecules and/or pathogens (like the virus causing COVID-19), it is equally important that it does not attack our own cells and organs (which is what occurs in autoimmune diseases).
This delicate balance is, in part, maintained by immune-suppressive cells known as T regulatory cells (Tregs).
(📸: blog.quartzy.com/iq_biosciences…)
(📸: blog.quartzy.com/iq_biosciences…)
a removal of a subset of #Tregs called T follicular regulatory cells (Tfr) from the immune system in #Foxp3-cre Bcl6-fl/fl mice #paradoxically reduces, rather than increases, #peanut-specific #IgE responses.
#immunology
bit.ly/2RAMe8L
#immunology
bit.ly/2RAMe8L
And if you think maybe their knockout mice are some kind of weirdos, not really. Their model also shows that total IgE is increasing as expected. So, the system the authors are using is within acceptable norms.
bit.ly/2RAMe8L
bit.ly/2RAMe8L
The authors then went on to show that IL-10 derived from Tfr cells are important for promoting peanut allergy-producing IgE production. (IL-10 is lesser understood cytokine but it is generally accepted as an immunosuppressant.) #immunology
1/ New insights into control of #tregs by #DNAmethylation from #SingerLab. #epigenetics @luisamnMD @NMPulmCritCare
Check out our new preprint on @biorxivpreprint: biorxiv.org/cgi/content/sh…
Check out our new preprint on @biorxivpreprint: biorxiv.org/cgi/content/sh…
2/ Treg cells are known to require a lineage-specific DNA hypomethylation pattern during development that stabilizes their lineage. We wanted to determine whether maintenance DNA methylation is required for Treg cell lineage development and stability.
3/ Accordingly, we bred mice with Treg cell-specific deficiency in the epigenetic regulator Uhrf1, which maintains methyl-DNA marks. These mice displayed a profound inflammatory phenotype.
