Discover and read the best of Twitter Threads about #TresAmigos
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Finally got to analyze & put my thoughts together on the recent #posaconazole vs. #voriconazole phase 3 trial for invasive #aspergillosis published in .@TheLancet a few weeks ago.
Best is to put the major trials of the 3 #VIP triazoles done over the last 20 years in perspective!
Best is to put the major trials of the 3 #VIP triazoles done over the last 20 years in perspective!
So (re)studied the following key trials & appendices
#Posaconazole vs. #Voriconazole: thelancet.com/journals/lance…
#Isavuconazole vs. Vori: thelancet.com/journals/lance…
#AmphotericinB vs. Vori: nejm.org/doi/10.1056/NE…
#TxID #IDTwitter
#Posaconazole vs. #Voriconazole: thelancet.com/journals/lance…
#Isavuconazole vs. Vori: thelancet.com/journals/lance…
#AmphotericinB vs. Vori: nejm.org/doi/10.1056/NE…
#TxID #IDTwitter
Here is the table with key points of trial design of the #TresAmigos trials, interesting features:
#Vori-Ampho was open label, but with blinded adjudication, including to adverse effects.
All where non-inferiority trials, #vori-amphoB had a clause for claiming superiority.
#Vori-Ampho was open label, but with blinded adjudication, including to adverse effects.
All where non-inferiority trials, #vori-amphoB had a clause for claiming superiority.
