Discover and read the best of Twitter Threads about #TristanJordan
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As promised, here’s an overview of our study to find host factors required for SARS-CoV-2 infection in human cells. We use a genome-wide CRISPR screen to identify genes (& key mechanisms) that might be therapeutically targetable to prevent viral infection. 
Here’s a link to the manuscript (open access):
cell.com/cell/fulltext/…
cell.com/cell/fulltext/…
First & foremost: HUGE shout-out to first authors @ZDaniloski & #TristanJordan who worked incredibly hard to complete this study in a short time. Key ingredient was the great relationship btwn Zharko & Tristan: They made this happen. Full acknowledgements @ end of the 🧵.
Happy to share our new preprint characterizing a recent mutation in SARS-CoV-2 Spike protein (D614G) and its potential functional impact on the ability of the virus to transduce human cells.
First, this work was spearheaded by a talented postdoc in our group #ZharkoDaniloski and is a wonderful example of curiosity-based science.
In April, we learned that one particular mutation had become dominant among COVID-19 cases worldwide. Here’s a nice visualization using the Nextstrain website to see this mutation in the Spike protein appearing around February:
