Discover and read the best of Twitter Threads about #Tumors
Most recents (6)
1/As promised & after reading $CRSP latest Q4 2022 #financial #report here is my impression regarding @CRISPRTX latest corporate status. I have focused only on the main issues that I found to be the most interesting & relevant. #CRISPR #BioTech #FinTwit #Genomics #GeneEditing 🧵 
2/IMO the most significant corporate event in Q4 was $CRSP announcement that regulatory Exa-cel submissions of both #SickleCell & #BetaThalassemia validated in the #EU & #UK & that the @US_FDA BLA submission is on track by the end of Q1 ‘23 - possibly reaching the #markets in ‘23
3/Exa-cel/CTX001 - the key program in $CRSP portfolio, is an #autologous Ex-Vivo #CRISPR/#Cas9 #GeneEditing therapy aimed for patients suffering from #TDT or severe #SCD. The latest readout for both programs was phenomenal with 42/44 TDT & 31/31(!) demonstrated remarkable results
Standard cancer detection tests are done with #tissuebiopsies.🧫
These are invasive, risky, and expensive as they require an endoscope and open surgery.
An alternative approach to this is Liquid Biopsy which is performed by drawing blood.🩸
2/n
These are invasive, risky, and expensive as they require an endoscope and open surgery.
An alternative approach to this is Liquid Biopsy which is performed by drawing blood.🩸
2/n
Liquid biopsy is an innovative solution to #cancerdetection.
▪️They use a much smaller sample and have a quicker turnaround for results compared to tissue biopsies.
▪️They are more advantageous in detecting a metastasized tumor - when cancer has spread to multiple sites.
3/n
▪️They use a much smaller sample and have a quicker turnaround for results compared to tissue biopsies.
▪️They are more advantageous in detecting a metastasized tumor - when cancer has spread to multiple sites.
3/n
Very happy to see our microRNA metastases paper out. co-led by @HyeEirik and by many fantastic colleagues
We show the reasons for previously published contradicting reports of de-regulated #microRNAs in colorectal cancer #tumors and #metastases:
tinyurl.com/yckwdk2z
We show the reasons for previously published contradicting reports of de-regulated #microRNAs in colorectal cancer #tumors and #metastases:
tinyurl.com/yckwdk2z
Among them are
- lack of correction for background expression
- different metastatic sites were not analyzed as separate entities
- expression cut-off level for microRNAs to ensure biological relevance are typically not used
- lack of correction for background expression
- different metastatic sites were not analyzed as separate entities
- expression cut-off level for microRNAs to ensure biological relevance are typically not used
We establish a stringent, reproducible and easily expandable bioinformatics pipeline (github.com/eirikhoye/mirn…) that we applied on all previously published (depending on availability) and a large range of novel smallRNA sequencing datasets, altogether 268 datasets.
Happy 2021! @MBVanElzakker and I are excited to share our new article published in #Immunometabolism: “Pathogens Hijack Host Cell Metabolism: Intracellular Infection as a Driver of the Warburg Effect in Cancer and Other Chronic Inflammatory Conditions”: ij.hapres.com/htmls/IJ_1341_…
2/ In the paper, we detail molecular mechanisms by which #viral, #bacterial, and #parasite intracellular pathogens can induce, or contribute to, a Warburg-like #metabolism in infected host cells in order to meet their own replication and nutritional needs.
3/ We also discuss how host defense towards #infection may impact cellular metabolic changes (including how #mitochondria can participate in the innate immune response towards infection)
Canada's #5G rollout
"A larger number of connected devices will result in huge increases in data that need to be stored in energy-intensive #data centres, which are expected to emit more #carbon than the international #aviation industry."
#Climate
macleans.ca/opinion/threat…
"A larger number of connected devices will result in huge increases in data that need to be stored in energy-intensive #data centres, which are expected to emit more #carbon than the international #aviation industry."
#Climate
macleans.ca/opinion/threat…
"It also means an exponential increase in the # of wireless networks, which are energy-guzzlers (est. to be 10x less efficient than wired networks). In 2015 alone, the energy used to power wireless networks generated approx. 30 megatonnes of carbon, the same as 4.9 million cars."
In the middle of this terrible time w/ COVID19 comes this amazing paper with huge implications for #cancer 👉”Microbiome analyses of blood and tissues suggest cancer diagnostic approach”: nature.com/articles/s4158…
2/ Here’s a press release with more on the study: health.ucsd.edu/news/releases/…
