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Have you ever seen a single-arm, non-randomized study with survival curves showing one subgroup of patients doing better the other and thought "wow, that drug must improve survival in that responding subgroup"?
Learned from @VinayPrasadMD about this type of analysis, called "survival by tumor response". Paper published in JCO in 1983 by Anderson et al. describes this in detail.
Although I don't consider myself a #Tweetorialist, I will try a mini-#Tweetorial summarizing this paper and hope that @ProfDFrancis approves
