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Please check out our latest publication on pathological protein succinylation in humans:
"SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease"
doi.org/10.1038/s41467…
"SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease"
doi.org/10.1038/s41467…
I first got involved in this project in 2016, and I gave an oral presentation on this at #USHUPO 2018.
Very fortunate to be part of this worldwide collaborative team, including: California, North Carolina, Wisconsin, Switzerland, and Sweden
Very fortunate to be part of this worldwide collaborative team, including: California, North Carolina, Wisconsin, Switzerland, and Sweden
This started with Philipp's observation that succinyl-CoA binding proteins of the complex succinyl-CoA ligase (SCL) had higher succinylation than other proteins in the TCA cycle 
