Discover and read the best of Twitter Threads about #UnintendedConsequence
Most recents (2)
1/15: My new paper in Harm Reduction Journal simulates what the US situation might look like if we promote e-cigarettes as a harm reduction policy: rdcu.be/cg94K . Hint: #VapingSavesLives
2/15: In system dynamics modeling, it’s important to focus on a specific, measurable problem to solve. Here, it’s the combustible tobacco-related death burden (~480,000 lives/year).
3/15: We also need a specific goal for the tobacco-related death rate. Since it's unreasonable to expect zero tobacco use, I've set the goal to that of accidental deaths (1% of the population) – below that attributed to poor diet/physical inactivity or alcohol.
So folks wanted a #journalclub on the @JAMAPediatrics paper on #epidurals and #autism. Ok......here we go!
1. Let's review the intro first. Beyond conjecture, they offer scant data to justify their study which was an animal study (ref 5). They say 'standard clinical doses of LAs 👇produce neurotoxic effects & altered neurobeh devlpment in monkeys.' 
These aren't standard doses. We use in fact substantially lower concentrations & doses of epidural local anesthetics. Plus, this small study in non-laboring monkeys included multiple behav outcomes. So high likelihood of chance finding. Also, anyone know if monkeys get ASD??
