Discover and read the best of Twitter Threads about #VV116
Most recents (3)
2) #TVG489
Allogenic CAR T cells
These will hopefully be able to clear infected cells, if T cell evasion by SARS-CoV-2 (via MHC I downregulation) can be overcome
labiotech.eu/trends-news/te…
Allogenic CAR T cells
These will hopefully be able to clear infected cells, if T cell evasion by SARS-CoV-2 (via MHC I downregulation) can be overcome
labiotech.eu/trends-news/te…
I have wondered why ph2/3 #VV116 trials exclude participants with eye disease (super specific imo)
From study protocol: Conjunctiva and cornea changes were noted in dogs treated at 250 mpk
A VV116-specific effect or also applicable to #GS441524 prodrugs @GileadSciences?
From study protocol: Conjunctiva and cornea changes were noted in dogs treated at 250 mpk
A VV116-specific effect or also applicable to #GS441524 prodrugs @GileadSciences?
I am reminded of the FDA-approved ocular drugs that are ester prodrugs. Added lipophilicity + esterase expression in cornea might explain preclinical ocular tox with VV116 in dogs.
BIG NEWS: deuterated #GS441524 tri-iBu ester (#VV116) is in clinical trials in Uzbekistan for #COVID19. Trials in China 🔜. Developed by the one and only *Wuhan Institute of Virology*. Deuterium was added to bypass @GileadSciences 💊 1/4
@ncats_nih_gov
shine.cn/news/nation/21…
@ncats_nih_gov
shine.cn/news/nation/21…
Official article published in @cell_res in September 2021 by the folk at Wuhan Institute of Virology. Original @biorxivpreprint was published in November 2020. 2/4
nature.com/articles/s4142…
nature.com/articles/s4142…
Chinese patent by the WIV first filed in Sept 2020. WO patent filed in April 2021. Gilead's 2009 patent on 524 and the 2016 patent on #remdesivir do not include any of the compounds described in the WIV patent. Does Gilead actually own any of these WIV compounds?? 3/4
