Discover and read the best of Twitter Threads about #VX548

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Since obeldesivir, figuring out the structure of undisclosed cmpds in the clinic has become my new hobby 🤠

So I'll periodically post structures of other cmpds here

I'll start w #VX548, a Nav1.8 inhibitor for treating pain by @VertexPharma $VRTX. Inspired by @cispt2 1/8
VX-548 is currently in ph3 for the tx of acute pain. From trials registry, the earliest trial date is on July 19, 2021. 2/8
A series of patents were recently published by Vertex on the same series of the inhibitors (Dec. 8, 2022)

These all have the same priority/filing/publish dates

Earliest priority traces back to June 4, 2021: ~1 mo. earlier than 1st trial reg (July 19, 2021) 3/8
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