Discover and read the best of Twitter Threads about #Visium
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Excited to announce our new method #CytoSPACE for mapping single cells from a reference atlas to #SpatialTranscriptomics (ST) data at high resolution, out now in @NatureBiotech! 1/10
nature.com/articles/s4158…
nature.com/articles/s4158…
Available assays for ST lack single-cell resolution (e.g. #Visium) or have limited gene recovery (e.g. #MERSCOPE).
CytoSPACE computationally reconstructs tissue specimens to obtain high gene coverage and spatially-resolved scRNA-seq data suitable for downstream analysis. 2/10
CytoSPACE computationally reconstructs tissue specimens to obtain high gene coverage and spatially-resolved scRNA-seq data suitable for downstream analysis. 2/10
CytoSPACE works by constrained global optimization to yield robust mappings, outperforming existing methods across benchmarks. 3/10 
In #biotech #stocks news, $TXG @10xGenomics is opening upwards +4% in today's trading. The company is down more than 75% in the 52-wk window. They peaked in Q1 2021 and have since then declined at a similar pace as other $XBI stocks out there.
$TXG is in the #Singlecell and #Spatial biology field. They've recently made their pivot into Spatial Biology apparent, and have both an #NGS Next-Generation Sequencing and #InSitu imaging play on it, with their #Visium and #Xenium lines respectively.
The $TXG top institutional holders include Morgan Stanley with less than 10%, followed by 3 of the heavy hitters in #biotech: UK's Baillie Gifford, Vanguard Group, and Black Rock.
My highlights of the @10xGenomics #Xperience2021 event. The list of products keeps growing, I would highlight Chromium Connect as an underappreciated tool to bring the products up another level of throughput. Important as with #NGS, it won't take long to go from n=1 to n=96+.
#CellPlex species-agnostic multiplexing up to 12 samples: not dissimilar to products such as TotalSeq, but baked-in so that it's been tested to work with the rest of the workflow.
Going close to 1M cells, the #ChromiumX brings about 100x fold throughput increase, all marked with 'HT' in the Kits. I'd be interesting to know how the different #BodyAtlas projects embrace this and for what.
#JPM2021 @10xGenomics My Highlights:
Fixed RNA: does this mean less ambient RNA, higher efficiency even if the original sample is fresh?
Fixed RNA: does this mean less ambient RNA, higher efficiency even if the original sample is fresh?
#ChromiumX 1M cells per run experiment. No word on price per bead compared to Chromium NextGEM.
