Discover and read the best of Twitter Threads about #Weightloss
Most recents (24)
The findings of this one suggest that dietary carbohydrate and exercise may generate independent and interactive effects on the plasma metabolome, resulting in the generation of distinct metabolic phenotypes that may influence appetite regulation and perhaps energy intake. 
- This study aimed to determine the interactive effects of carbohydrate and exercise on the plasma hormonal and metabolite responses and explore potential mediators of exercise-induced changes in appetite and energy intake across nutritional states.
- In a randomised-crossover fashion, 12 male participants completed four study visits that involved the consumption of a control (water) or carbohydrate beverage (75 g maltodextrin, 300 kcal), followed by a 30-minute rest or exercise session (75% V'O2max on a cycle ergometer).
This umbrella review finds that the evidence from meta-analyses of Randomised Controlled Trials overall suggests that resistance training is likely to be a suitable intervention for persons with sarcopenic obesity, although the results may be suboptimal, in general.
- This is the first umbrella review on sarcopenic obesity conducted to provide comprehensive insights into the effectiveness of different nutrition and exercise interventions for adults.
- Four systematic reviews with between 30 to 225 participants were included in the umbrella review.
In this one, sustained weight loss was associated with lower HbA1c at 10 years and improvement in lipid profile, while maintenance of ≥7% weight loss at 1 year was associated with decreased incidence of diabetic nephropathy at 10 years in patients with diabetes.
- The study evaluated 129 patients with diabetes and obesity enrolled in a 12-week translational model of intensive lifestyle intervention.
- At 1 year, participants were divided into group A, who maintained <7% weight loss (n=61, 47.7%), and group B, who maintained ≥7% weight loss (n=67, 52.3%).
Follow-up was continued for 10 years.
Follow-up was continued for 10 years.
In this one, an intervention of 200 minute of walking per day was associated with profound effects on the metabolic profile of the participant, a reduced body weight, similar in magnitude to that seen after bariatric surgery, and increased fatty acid beta-oxidation.
- This was a feasibility study of a subject who performed an exercise intervention of low-intensity, non-fatiguing walking on a deskmill/treadmill for 200 minutes daily, approximately the average time a German spends watching television per day, for 6 days a week, for 4 weeks.
- Data suggested that walking can have a profound effect on the metabolism of a person – an effect that is visible both acutely as well as after 1.5 days.
🧵 How Gila monster’s venom inspired a new fat-loss drug that everyone is talking about.
A story of unlikely collaboration.
This is how Semaglutide (Ozempic) was invented:
A story of unlikely collaboration.
This is how Semaglutide (Ozempic) was invented:
Semaglutide is an injectable drug that is used to treat Type 2 diabetes.
But, how did a diabetes drug become a potential game-changer for obesity?
It all started in 1995.
But, how did a diabetes drug become a potential game-changer for obesity?
It all started in 1995.
An endocrinologist named Daniel Drucker learned that the venom of Gila Monster lizard contained hormones that can regulate blood sugar.
His curiosity led to a call with a zoo in Utah & had a lizard shipped to his lab where he started experimenting on the deadly venom.
His curiosity led to a call with a zoo in Utah & had a lizard shipped to his lab where he started experimenting on the deadly venom.
Ready for an #obesity #research disruptor?
@bcorkey 's studies on hyperinsulinemia and inflammation are a perennial favorite
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@bcorkey 's studies on hyperinsulinemia and inflammation are a perennial favorite
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We often focus on slow or fast metabolism but there isn't enough talk on *energy efficiency*. See how much additional Δkcal is required (beyond that calculated) to effect 10% weight Δ: nejm.org/doi/full/10.10…
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Tony Ferrante MD PhD of @ColumbiaMed providing an excellent systems based overview of the "metabolic" complications of #obesity and potential mechanisms: lipotoxicity, inflammation, adipokines
Some highlights:
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Some highlights:
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Neurology:
Check out this relationship where higher BMI is associated with ↑ risk of #dementia EXCEPT in age >70 when it's better to be in "overweight" category
👉Aiming for a "normal BMI" is not the best goal for everyone
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Check out this relationship where higher BMI is associated with ↑ risk of #dementia EXCEPT in age >70 when it's better to be in "overweight" category
👉Aiming for a "normal BMI" is not the best goal for everyone
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For example:
Are you asking patients to "try lifestyle changes" first before referring them to specialty care? (eg, endocrinology, bariatric surgery)
This is a subtle example of #weightbias
(Assuming they haven't tried already)
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Are you asking patients to "try lifestyle changes" first before referring them to specialty care? (eg, endocrinology, bariatric surgery)
This is a subtle example of #weightbias
(Assuming they haven't tried already)
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A 2009 study found that MDs self-reported less respect for patients with higher BMI
ncbi.nlm.nih.gov/pmc/articles/P…
There must be longitudinal studies demonstrating this has improved since 2009??? @scottkahan @ConscienHealth
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ncbi.nlm.nih.gov/pmc/articles/P…
There must be longitudinal studies demonstrating this has improved since 2009??? @scottkahan @ConscienHealth
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From a non-runner to #running half marathons: snippets from this amazing ongoing journey
1. Nov 2020: Age 49 yrs, Wt: 95 Kg, no prior running experience. Decided to start my running journey. No personal coach or nutritionist. Aim was #weightloss and to improve #fitness
1. Nov 2020: Age 49 yrs, Wt: 95 Kg, no prior running experience. Decided to start my running journey. No personal coach or nutritionist. Aim was #weightloss and to improve #fitness
2. Running highlights:
2021: 339 runs of 10k or longer; 69 Half marathons (HM); 1 marathon
2022: 304 runs of 10k or longer, 43 HM
2023 (until today): 44 runs of 10k or longer, 7 HM
Personal best: 10k- 51:11 minutes; HM: 1:55:34 hours
2021: 339 runs of 10k or longer; 69 Half marathons (HM); 1 marathon
2022: 304 runs of 10k or longer, 43 HM
2023 (until today): 44 runs of 10k or longer, 7 HM
Personal best: 10k- 51:11 minutes; HM: 1:55:34 hours
3. Modifications in my daily routine
*Started sleeping 8 hours (earlier 5 hours)
*Started waking up at 5 AM instead of 7 AM
*Shifted dinner time to 7 PM from 10 PM
*Reduced daily working hours to 9 hours (earlier 15 hours) including patient care, research & teaching
*Started sleeping 8 hours (earlier 5 hours)
*Started waking up at 5 AM instead of 7 AM
*Shifted dinner time to 7 PM from 10 PM
*Reduced daily working hours to 9 hours (earlier 15 hours) including patient care, research & teaching
In this one, a phenotype-tailored lifestyle intervention was associated with further improvements in measures of body composition and triglycerides compared with a standard lifestyle intervention.
- This 12-week, single-centre non-randomised proof-of-concept clinical trial included men and women aged 18–65 years with a body mass index (BMI) greater than 30 without history of any bariatric procedure, and current use of any medication known to affect weight.
- Participants were assigned to their intervention based on their period of enrollment.
The findings of this one may suggest that individuals with lower habitual exercise and/or higher fasting concentrations of PYY are more likely to show a compensatory increase in energy intake for energy expended in exercise.
- The present study aimed to identify predictors of post-exercise energy intake and compensation in healthy adults following a single 45-min aerobic exercise bout.
- Individuals with lower habitual exercise and/or higher fasting concentrations of PYY ate more after an acute exercise bout, even after accounting for the energy expended during the exercise bout.
This systematic review finds that the literature overall suggests that the metabolizable energy of nuts is lower than that predicted by Atwater factors, something that may in part explain the lack of an effect of nut consumption on body weight reported in the literature.
- This systematic review with narrative synthesis aimed to examine the metabolizable energy of tree nuts and peanuts in vitro and in adult humans.
- Findings suggest that the metabolizable energy of the nut types investigated (almonds, cashews, hazelnuts, pistachios, walnuts, and peanuts) is lower than what would be expected following application of Atwater factors.
In this one in adults with obesity without diabetes who initially lost at least 5% of body weight, only the combination of an aerobic exercise program and a GLP-1 receptor agonist improved postprandial glucose & glucagon responses and beta cell function compared with placebo.
- The aim of this study was to investigate glucose tolerance, glucagon response, and beta cell function during a 1-year maintenance period with either exercise, the glucagon-like peptide-1 receptor agonist liraglutide, or the combination after diet-induced weight loss.
- In this randomized placebo-controlled trial, adults with obesity (BMI: 32–43 kg/m2) without diabetes underwent an 8-week low-calorie diet (800 kcal/d) and were randomized to 52 weeks of aerobic exercise, liraglutide 3.0 mg/d, exercise and liraglutide combined, or placebo.
The findings of this one suggest indicate no individual or additive benefit of higher dietary quality on working memory during a 2-year calorie restriction period in healthy adults without obesity and a mean age of 38.1 years.
- The study tried to evaluate the association between dietary quality and spatial working memory in healthy adults without obesity (aged 21–50 y) during a 2-year calorie restriction intervention.
- Two dietary pattern indices with different underlying principles were used: 1) the Dietary Inflammatory Index (DII), which is a validated tool designed to assess the inflammatory potential of individual diets...
In this one, an 8-hour time-restricted eating (TRE) protocol was not associated with additional benefits for reducing intrahepatic triglyceride content, body fat and metabolic risk factors compared with daily calorie restriction in adults with obesity and NAFLD.
- All participants were instructed to follow a diet of 1500 to 1800 kcal/d for men and 1200 to 1500 kcal/d for women.
- The diets were composed of 40% to 55% carbohydrate, 15% to 20% protein, and 20% to 30% fat.
🚨Only Diet,No Workout 🚨
🤔🤔🤔🤔🤔🤔🤔🤔
◾फक्त Diet ने वजन कमी करता येईल का?
◾"Calories Burning मध्ये Exercise ही Ineffective आहे" असे Expert का म्हणतात?
◾Weight Loss साठी कोणता Approach Best राहिलं?
◾सगळं काही जाणून घेऊयात 👇या Thread मध्ये.
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🤔🤔🤔🤔🤔🤔🤔🤔
◾फक्त Diet ने वजन कमी करता येईल का?
◾"Calories Burning मध्ये Exercise ही Ineffective आहे" असे Expert का म्हणतात?
◾Weight Loss साठी कोणता Approach Best राहिलं?
◾सगळं काही जाणून घेऊयात 👇या Thread मध्ये.
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▪️वजन कमी करण्यासाठी जेवढ्या Calories खातो, त्यापेक्षा जास्त Calories Burn केल्या पाहिजेत हे आपल्या सर्वांना च माहिती आहे.
▪️पण आपली Body कोणकोणत्या मार्गाने Calories Burn करते ते आधी पाहुयात👇
◼️How Body Burn Calories◼️
▪️BMR.
▪️NEAT.
▪️TEF.
▪️Exercise.
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▪️पण आपली Body कोणकोणत्या मार्गाने Calories Burn करते ते आधी पाहुयात👇
◼️How Body Burn Calories◼️
▪️BMR.
▪️NEAT.
▪️TEF.
▪️Exercise.
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◾BMR - Basal Metabolic Rate◾
- आपल्या शरीराचं Basic Function👇 चालू ठेवण्यासाठी लागणाऱ्या Minimum Amount Of Calories म्हणजे BMR.
- Basic Function - Breathing, Blood Circulation etc.
- आपल्या Total Calories Burning च्या 👉👉60-80% Calories या BMR मध्ये Burn होतात.
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- आपल्या शरीराचं Basic Function👇 चालू ठेवण्यासाठी लागणाऱ्या Minimum Amount Of Calories म्हणजे BMR.
- Basic Function - Breathing, Blood Circulation etc.
- आपल्या Total Calories Burning च्या 👉👉60-80% Calories या BMR मध्ये Burn होतात.
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This one failed to find a reduction in nonexercise physical activity after exercise, after either a bout of resistance or aerobic exercise.
- A reduction in nonexercise physical activity after exercise may reduce the effectiveness of exercise interventions on weight loss in adults with overweight or obesity.
- The purpose of this secondary analysis was to examine the effect of a single bout of aerobic or resistance exercise on nonexercise physical activity and sedentary behavior in inactive adults with overweight or obesity.
Emulsifiers! You unknowingly consume them daily. They are in almost every readymade food. But what are these and what impact they have on your #health. In below thread, i explore the world of #emulsifiers and why you should avoid them. #HealthyLiving #weightloss #processedfood
Emulsifiers are detergent that combine different substances together. Certain substances in food are water soluble & others are fat soluble. How to mix them together? Add emulsifiers & voila - problem solved
The emulsifiers mostly have names that is difficult to pronounce but you can see them in food ingredients list on packaging. Common ones are polysorbate 20, 60 or 80 (P80), carboxymethyl cellulose (CMC), sorbitran, propylene glycol, sodium stearoyl lactylate, Gum arabic
Here, the combination of exercise and a GLP-1 receptor agonist reduced metabolic syndrome severity, abdominal obesity, and inflammation following an eight-week low-calorie diet, consequently reducing cardiometabolic risk more than exercise or the GLP-1 receptor agonist alone.
- The study investigated improvements in metabolic syndrome, abdominal obesity, and low-grade inflammation during moderate-to-vigorous exercise, liraglutide 3.0 mg/day, or the combination of the two following an eight-week low-calorie diet...
...in a one-year maintenance period following a diet-induced weight loss.
This systematic review and meta-analysis suggests that beetroot or nitrate supplements are not likely to improves body composition indices regardless of supplement dosage, trial duration, and athletic status.
- All included studies indicated that beetroot or nitrate supplementation are not likely to change body composition indices of the intervened groups compared with controls.
- Subgroup analyses suggested no significant differences in body composition-related outcomes between subgroups in terms of duration of intervention, dose, study design, baseline BMI of participants, and athletic status (athlete versus non athlete).
🔶चपाती की भाकरी? नक्की काय खावे🔶
🔸Jowar Roti Or Wheat Roti🔸
-बरेच जण म्हणतात चपाती ने वजन वाढतं.
-वजन कमी करायची असेल तर भाकरी खावा.
-मधुमेह असणाऱ्यांनी चपाती ऐवजी भाकरी निवडावी.
-यामध्ये खरंच काही तथ्य आहे का?
सगळं काही जाणून घेऊयात या Thread मध्ये👇
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🔸Jowar Roti Or Wheat Roti🔸
-बरेच जण म्हणतात चपाती ने वजन वाढतं.
-वजन कमी करायची असेल तर भाकरी खावा.
-मधुमेह असणाऱ्यांनी चपाती ऐवजी भाकरी निवडावी.
-यामध्ये खरंच काही तथ्य आहे का?
सगळं काही जाणून घेऊयात या Thread मध्ये👇
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▪️गेले बरेच दिवसांपूर्वी Whatsapp वर "जेवणात का खावी ज्वारीची भाकरी""ज्वारीच्या भाकरीचे महत्व" असे Messages पाहिले.
▪️या मेसेज मध्ये "गव्हामुळे अनेक आजार होतात, वजन वाढतं, Acidity वाढते आणि बरेच काही सांगितलं होतं".
▪️असे मेसेज समाजात प्रबोधनाऐवजी गैरसमज च जास्त पसवरतात.
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▪️या मेसेज मध्ये "गव्हामुळे अनेक आजार होतात, वजन वाढतं, Acidity वाढते आणि बरेच काही सांगितलं होतं".
▪️असे मेसेज समाजात प्रबोधनाऐवजी गैरसमज च जास्त पसवरतात.
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🔶चपाती भाकरी मधील Macronutrient🔶 Per 100Gm Of Grain.
▪️Carbohydrate▪️
गहू - 72 Gm.
ज्वारी - 72 Gm.
▪️Protein▪️
गहू - 13 Gm.
ज्वारी - 11 Gm.
▪️Total Calories▪️
गहू - 340 Calories.
ज्वारी - 329 Calories.
वरील Comparison वरून समजलं असेल की दोघांमध्ये फार मोठा फरक नाहीये.
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▪️Carbohydrate▪️
गहू - 72 Gm.
ज्वारी - 72 Gm.
▪️Protein▪️
गहू - 13 Gm.
ज्वारी - 11 Gm.
▪️Total Calories▪️
गहू - 340 Calories.
ज्वारी - 329 Calories.
वरील Comparison वरून समजलं असेल की दोघांमध्ये फार मोठा फरक नाहीये.
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🚨 Fat Burning Hormones 🚨
◼️"हॉर्मोन" जे आपली 'चरबी कमी' करतात◼️
▪️हे हॉर्मोन्स कसे काम करतात.
▪️कधी चांगल्या प्रमाणत तयार होतात.
▪️कोणत्या गोष्टी मुळे हॉर्मोन लेवल बिघडते.
▪️नॉर्मल लेवल राहण्यासाठी काय करावे.
सगळं काही जाणून घेऊयात,या Thread मध्ये
👇👇
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◼️"हॉर्मोन" जे आपली 'चरबी कमी' करतात◼️
▪️हे हॉर्मोन्स कसे काम करतात.
▪️कधी चांगल्या प्रमाणत तयार होतात.
▪️कोणत्या गोष्टी मुळे हॉर्मोन लेवल बिघडते.
▪️नॉर्मल लेवल राहण्यासाठी काय करावे.
सगळं काही जाणून घेऊयात,या Thread मध्ये
👇👇
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🔶T3 Hormone:
▪️Thyroid Gland मध्ये तयार होतात,
▪️शरीरात Metabolism Control करण्याचं काम करतात,
▪️ज्यावेळी आपण 'Stress Free' असतो त्यावेळी T3 शरीरात चांगल्या प्रमाणत तयार होतं,
▪️पण Irregular Eating, पुरेसा आहार न घेणं, Refined Oils चा अतिवापर यामुळे T3 च Secretion कमी होतं.
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▪️Thyroid Gland मध्ये तयार होतात,
▪️शरीरात Metabolism Control करण्याचं काम करतात,
▪️ज्यावेळी आपण 'Stress Free' असतो त्यावेळी T3 शरीरात चांगल्या प्रमाणत तयार होतं,
▪️पण Irregular Eating, पुरेसा आहार न घेणं, Refined Oils चा अतिवापर यामुळे T3 च Secretion कमी होतं.
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▪️✅Stressful Situation पासून दूर राहणे, Stress Removal Activities करणे, Refined food, Refined Oils चं प्रमाण कमी करणे, यामुळे T3 योग्य प्रमाणात तयार होण्याला मदत होते.
🔶Growth Hormone (GH):
▪️जसं की याचं नाव आहे हे Growth Control
करतात.
▪️लहानपणी ज्या मुलांची वाढ खुंटलेली
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🔶Growth Hormone (GH):
▪️जसं की याचं नाव आहे हे Growth Control
करतात.
▪️लहानपणी ज्या मुलांची वाढ खुंटलेली
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Time-restricted eating alone may not result in long-term weight loss
1. Time-restricted eating (TRE), a form of #IntermittentFasting (IF), has gained popularity for #weightloss.
However, weight loss was not seen in a recently published study with TRE.
#obesity #MedTwitter
1. Time-restricted eating (TRE), a form of #IntermittentFasting (IF), has gained popularity for #weightloss.
However, weight loss was not seen in a recently published study with TRE.
#obesity #MedTwitter
2. 547 participants (78% women, mean age 51 years, mean BMI 30.8) were followed up for 6 years.
*Mean interval from first to last meal was 11.5 hours and was not associated with weight change.
*The number of #meals per day was positively associated with weight change.
*Mean interval from first to last meal was 11.5 hours and was not associated with weight change.
*The number of #meals per day was positively associated with weight change.
3. Total daily number of large (>1000 calories) and medium meals (500-1000 calories) was associated with increased weight over follow‐up time, while total number of small meals (<500 calories) was associated with decreasing weight.
Contrary to some studies suggesting that time‐restricted eating could improve circadian rhythms and play a role in metabolic regulation, this one found that the frequency and the size, rather than the timing, of meals to be stronger determinants of weight change over time.
- The window of time between first to last meal was not associated with weight change over an average of about 6 years of follow‐up.
- The average daily number of large and medium meals was associated with increased weight over time, suggesting that the meal frequency and meal sizes, rather than the timing of meals, was a stronger determinant of weight gain over time.
