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We’re excited to share our newest publication @nature. With #scRNAseq we investigated 10 key #epigenetic regulators in #embryogenesis. Interesting early task for #Polycomb! Meissner lab @MPI_MolGen & @HSCRB /w @helenekretzmer & Zachary D. Smith (1/13) nature.com/articles/s4158…
What is normal in #devbio? First, we generated a single-cell reference of WT mouse #gastrulation and early organogenesis to which we later compared mutant phenotypes. We identified 42 embryonic and extraembryonic cell states and placed them in a lineage tree. (2/13) 
Our WT reference is time-resolved covering #embryo stages E6.5-8.5. Variation is information: We pooled multiple embryos with unique SNP profiles per single-cell experiment; cell-to-embryo assignment is possible from scRNA data. (3/13)
