Discover and read the best of Twitter Threads about #YALEIMPACT
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So wonderful to see this work published! Timing is everything when it comes to immune control of COVID. Neutralizing antibody production is delayed in lethal COVID. By the brilliant @carolilucas @sneakyvirus1 & #YaleIMPACT team 💪🏼(1/n)
For explanation about this study, please read this thread (2/n) 👇🏽
One additional piece of data to highlight - mRNA vax 1st shot (28 days) induces NAb comparable to hospitalized patients. Post 2nd shot vax (7 days) induces ⬆️ ⬆️ levels of NAb comparable to high neutralizers (HN). Thanks to @InciYildirim11 @SaadOmer3 #VaccinesWork (end) 
How does COVID reinfection happen?
Our deep dive into the immune profiles during the 1st and 2nd infections. A case study.
Work led by @sneakyvirus1 @AndersonBrito_ Paul Turbin @peowenlu @BenIsraelow and Marwan Azar (1/)
medrxiv.org/content/10.110…
Our deep dive into the immune profiles during the 1st and 2nd infections. A case study.
Work led by @sneakyvirus1 @AndersonBrito_ Paul Turbin @peowenlu @BenIsraelow and Marwan Azar (1/)
medrxiv.org/content/10.110…
To address this question, we first looked at other confirmed cases of COVID reinfection. The number of such cases is limited due to the requirement for viral genome sequences in both infections. (2/)
We noted that very little information is available regarding the immune responses that developed during the first infection that can explain why someone would get reinfected. (3/)
Problem: current PCR for #COVID19 testing requires multiple reactions per sample (2 viral and 1 host genes/ CDC assay). ⬆️ costs, reagents, labor and error rate.
A solution: "Detection of SARS-CoV-2 RNA by multiplex RT-qPCR" by Eriko Kudo et al. (1/n)
biorxiv.org/content/10.110…
A solution: "Detection of SARS-CoV-2 RNA by multiplex RT-qPCR" by Eriko Kudo et al. (1/n)
biorxiv.org/content/10.110…
We hope this method will help expand testing everywhere, particularly in resource-limited parts of the world. #TestTraceIsolate (2/n)
Teamwork 💪🏽 @BenIsraelow @VogelsChantal @peowenlu @awyllie13 @maria_tokuyama @arvieil @DougBrackney @IsabelOtt @MaryPetrone10 R. Earnest S. Lapidus C. Muenker @AJMooreHealth @arnaucasanovas @SaadOmer3 @DelaCruzYaleMed @ShelFarFar A. Ko & @NathanGrubaugh. #YALEIMPACT team! (end)
