Discover and read the best of Twitter Threads about #aacrmolepi

Most recents (1)

Re-upping my thread on the utility of small-effect GWAS findings in light of discussion at #AACRMolEpi Workshop (ahem @travisgerke). And adding a few comments about polygenic risk scores (PRS). /thread
While the potential utility of PRS in any particular context is up for debate, a blanket statement that “GWAS findings are not useful for prediction" is unwarranted.
Often the “modest” c-statistics for PRS (from 0.6 to 0.7) are cited as evidence that PRS are not useful. But there is no universal c-statistic threshold that determines utility. “How good is good enough” will depend on the context, what you want to do with the PRS.
Read 12 tweets

Related hashtags

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3.00/month or $30.00/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!