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Re-upping my thread on the utility of small-effect GWAS findings in light of discussion at #AACRMolEpi Workshop (ahem @travisgerke). And adding a few comments about polygenic risk scores (PRS). /thread
While the potential utility of PRS in any particular context is up for debate, a blanket statement that “GWAS findings are not useful for prediction" is unwarranted.
Often the “modest” c-statistics for PRS (from 0.6 to 0.7) are cited as evidence that PRS are not useful. But there is no universal c-statistic threshold that determines utility. “How good is good enough” will depend on the context, what you want to do with the PRS.
