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Our work #aboutime "Species-specific pace of development is associated with differences in protein stability" is now published science.sciencemag.org/content/369/65…. What determines the pace of embryonic development?
A comparative temporal analysis of the developing spinal cord in human and mouse embryos showed that the sequence of events in motor neuron formation is the same, yet the pace is different between mouse and human. What could be the cause? 🐭⌛️🚻⏳
We developed mouse and human motor neuron differentiation models from embryonic stem cells and found that human motor neurons progressed at a slower rate than mouse cells. This suggested that species-specific tempo differences are cell-intrinsic.
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