Discover and read the best of Twitter Threads about #acetate

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Does #gut #microbiota interact with #microglia in the #aging #brain? Are microglia metabolically affected (#mitochondria)? Does #diet take part? any #translational data?
Our paper made it last week in @NatureNeuro
so it's about time for a 🧵!
nature.com/articles/s4159… Image
1. Microglia from aged and young-adult #male & #female mice, under SPF or #germ_free conditions were profiled by bulk #RNAseq. We identified a gene-set, which depended on the housing condition regardless of #age & regulate central processes in microglia. "Microglial GF signature" Image
2. Utilizing #WGCNA, we found major differences between microglia of SPF and GF mice in the aged groups. But do we see any functional difference on a cellular level? Image
Read 13 tweets
Hey geomicrobiology and microbiome tweeps!

Do you know that the sulfosugar #sulfoquinovose (SQ) is a ubiquitous microbial nutrient in the environment and in a vegetarian diet?

No?

Here comes some SQ propaganda…a thread

#sulfurcycle #carboncycle #H2S #microbiome #diet Image
First, for #sulfoquinovose newbies, I very much recommend the wonderful review by Ethan Goddard-Borger @ethangbaus & Spencer Williams @sjwill99

Sulfoquinovose in the biosphere: occurrence, metabolism and functions portlandpress.com/biochemj/artic…
#sulfoquinovose is a sulfonated glucose and most often found as polar head group of sulfoquinovosyl diacylglycerol (SQDG), a ubiquitous sulfolipid in the photosynthetic membranes of all green land plants, algae, dinoflagellates, and cyanobacteria Image
Read 25 tweets

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