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NEXT Adaptive and Platform trial designs by @Lennie333 #datascience #ai #ml #icudata
#LIVES2022 #ventilation
@ESICM
we assume "large effect sizes" in ICU trials
@Lennie333 @ESICM this is because otherwise we will need large "n" and long time for trials.

e.g., anti-hypertensives - you dont want to test one drug at one dose. you want to test a range of doses and a range of duration.

third-thing : we struggle to find a end-point especially in critical care
@Lennie333 @ESICM huge effort doing RCT but we use "mortality" yes/no as a very binary endpoint. For patient, length of stay, quality of life after d/c important end points beyond survival.

in RCT, we cant learn whilst the trials are still running. in classic RCT.
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