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NEXT Adaptive and Platform trial designs by @Lennie333 #datascience #ai #ml #icudata
#LIVES2022 #ventilation
@ESICM
we assume "large effect sizes" in ICU trials
#LIVES2022 #ventilation
@ESICM
we assume "large effect sizes" in ICU trials
@Lennie333 @ESICM this is because otherwise we will need large "n" and long time for trials.
e.g., anti-hypertensives - you dont want to test one drug at one dose. you want to test a range of doses and a range of duration.
third-thing : we struggle to find a end-point especially in critical care
e.g., anti-hypertensives - you dont want to test one drug at one dose. you want to test a range of doses and a range of duration.
third-thing : we struggle to find a end-point especially in critical care
@Lennie333 @ESICM huge effort doing RCT but we use "mortality" yes/no as a very binary endpoint. For patient, length of stay, quality of life after d/c important end points beyond survival.
in RCT, we cant learn whilst the trials are still running. in classic RCT.
in RCT, we cant learn whilst the trials are still running. in classic RCT.
