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The fact that adaptive designs allow prespecified changes to be made to an ongoing trial based on interim results also creates the potential for biases to be introduced at different stages of the trial. #AdaptiveDesigns
This brings additional demands for transparency and adequate reporting of adaptive trials so that consumers of research findings can make informed judgements about the validity and trustworthiness of results. #AdaptiveDesigns
Inadequately reported adaptive trials that are difficult to interpret their results and reproduce methods, results, and inference. This can severely undermine public confidence in research findings to influence clinical practice resulting in research waste.
