Discover and read the best of Twitter Threads about #aids2022

@NPR

If you read just one #monkeypox article, make it this one, illustrating both the folly of not listening to people on the ground in the most affected communities & the perils of shaming & stigmatizing sex so much that people won't talk about it. 1/ @NPR

n.pr/3PPiCR5

@Dimostic

This Nigerian doctor, Dimie Ogoina (@Dimostic) just addressed a special #monkeypox session at #AIDS2022. 2/

Historically, based on experienced in African countries where #MPX has been known for decades, the virus was often contracted from contact with rodents & was considered difficult to transmit from person-to-person. 3/

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#Monkeypox vaccine messaging is difficult & conflicting because there's not enough research. Data so far is based on immunogenicity (essentially, antibody production) not real-world effectiveness. Starting with 1 dose is a good strategy to get more people some protection ASAP. 1/

@dr_demetre

But saying a single dose provides adequate protection is premature. In particular, people with #HIV have a lower response rate & it seems like they should be prioritized for 2nd doses. @dr_demetre says @US_FDA stands by its recommended 2-dose regimen. #AIDS2022 2/

I went into #AIDS2022 #monkeypox media briefing with many questions, but most don't yet have answers, including importance of various transmission routes in the real world, asymptomatic transmission, does HIV influence susceptibility, TPOXX efficacy, can isolation be shorter. 3/

Fernando Bernal Ortiz

@fernando_bernal

(1/4)VIH en el 2022: La visión de Anthony Fauci

Espectacular resumen de todos los avances alcanzados desde el inicio de la pandemia del VIH

-1989 fue el año del 1er AIDS realizado en Montreal
-75 Millones de diagnósticos desde 1989 y 40 Millones de muertes

#AIDS2022

(2/4)COVID ha amenazado la respuesta global contra el VIH y TBC (redujo acceso y diagnósticos), solo en USA reducción del 17% en nuevos diagnósticos
PEPFAR ha salvado 21Millones de vidas y ha permitido el acceso a TAR a 19Millones

(3/4)
- USA se ha propuesto reducción del 90% en nuevos diag. a 10 años (durante últimos 5 años, se ha reducido en un 75%)
- Esto sin duda demuestra la importancia de liderazgo continuo y que este que no dependa del gobierno de turno (Fauci ha estado a cargo del NIAID desde 1984)

Fernando Bernal Ortiz

@fernando_bernal

(1/3)Paciente Barcelona : Cura Funcional
- Mujer de 59 años
- Fue incluída en protocolo de infección aguda VIH con Inmunomoduladores (ciclosporina)
- Mantuvo indetectabilidad por 15 años, sin TAR, incluso sin presentar blips

#AIDS2022 #CureHIV

(1/2)
- No se documentaron los clásicos factores genéticos involucrados en una potente respuesta inmune

- Documentaron una reducción progresiva de los reservorios a través del tiempo (reducción del 98% en DNA viral, y 94% en DNA proviral)

(1/3)
- Se midió actividad NK y T-CD8+ en la inhibición de la replicación (62% CD8, 75% NK)

- Actividad atípica de NK (2veces mas alto de lo normal)
- NK expresan CD57 que promueven una potente respuesta citotoxica

- Alta actividad de T-CD8 (6 veces mas de lo normal)

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@mdoherty_hiv

And now at #AIDS2022: ad hoc #monkeypox media briefing with @mdoherty_hiv, Marina Klein, @ProfSharonLewin, @dr_demetre, @klts0 & @profchloeorkin.

@dr_demetre

.@dr_demetre: There's not one magic bullet. Learned lessons from #HIV that absolutes tend not to work, so focus on harm reduction. #Monkeypox vaccine supply & demand mismatch will probably go through the summer & fall. #AIDS2022

Marina Klein: Montreal was able to graft #monkeypox vaccine effort onto existing COVID vaccine infrastructure, with low threshold, evening hours, broad eligibility for gay/bi/MSM. #AIDS2022

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Fernando Bernal Ortiz

@fernando_bernal

Cura del VIH y vacuna
- La Relación entre los CD4 y la magnitud de la respuesta inmune es clave
- Papel critico desempeñan los Ac neutralizantes en la adquisición del VIH
- Los coctel de Ac podrían ser una herramienta en el control viral y cura funcional
#AIDS2022

- 3 estudios de eficacia de vacuna VIH no neutralizante indican que títulos altos de Ac del bucle V1V2 pueden desempeñar un papel e n la reducción de la adquizición del VIH
- Respuesta TCD8+ después de vacuna es clave en la respuesta innúmera para evitar adquirir VIH (HVTN505)

- Ac. Monoclonares: datos han demostrado una buena supresión virológica, siendo capaces de proveer una nueva ruta para el diseño de vacunas.

- Tecnología RNAm: INVITRO han demostrado hasta un 79% de reducción del riesgo (mas de 20 estudios anticipados para los próximos 2 años!!)

Joseph Cherabie MD, MSc🇱🇧🇺🇸🏳️‍🌈 (He/they)

@picardonhealth

And now, the Future of #HIV Media Coverage -- plus COVID & I won't be surprised if they mention #monkeypox. With @picardonhealth, @sciencecohen, @sarahboseley, @boosulyn, @SipokaziF, @apoorva_nyc, @rkhamsi & @ProfSharonLewin #AIDS2022

@sciencecohen

.@sciencecohen: There used to be AIDS journalists, that's rare now. With COVID, every reporter became a health reporter. Public more informed about science than ever before. But, adds @picardonhealth, they're more misinformed as well. #AIDS2022

@apoorva_nyc

How to balance COVID -- & now monkeypox -- with ongoing issues like #HIV/#AIDS?
@apoorva_nyc: When people stop seeing a disease as a threat to themselves, they don’t pay attention anymore. How do we get people to care about something that affects a specific population? #AIDS2022

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@JncherabieMD

#AIDS2022 Plenary Session on HIV in Indigenous Cultures in Canada
Stigma amongst Indigenous peoples with HIV still prominent, especially in rural areas still play a role, secondary to imposed ideology of Church and colonization
This is a major barrier to reaching 95-95-95 goals

A call for Indigenous People to be included as a Priority Population in the global HIV response, with global commitment to these peoples all around the world, wherever Indigenous People happen to be. #AIDS2022

Converging syndemic of HIV and the opioid epidemic, with COVID-19 exposing the cracks in the system, along with the increasing need to focus on and prioritize mental health during the lockdown has greatly affected Indigenous Peoples #AIDS2022

Joseph Cherabie MD, MSc🇱🇧🇺🇸🏳️‍🌈 (He/they)

@JncherabieMD

Good morning from Day 2 from #AIDS2022, first talk, the possibility of HIV mRNA Vaccine
Difficulties - HIV integrates into DNA, highly mutable, and complex response to HIV envelope glycoprotein

An mRNA vaccine was able to create broadly neutralizing antibodies however much different landscape on surface of HIV compared to SARS-COV-2
mRNA sticks around, is cheap to produce, easily modified, and creates endogenous protein
Of course vaccine equity is v important #AIDS2022

Possibility to Prime, then boost multiple times to create broadly neutralizing Abs, would require multiple clinical trials
IAVI G001 - 2 immunizations of vaccine, low dose and high dose arms, well tolerated, 94-97% response, increased mutation levels on second vaccine #AIDS2022

World Health Organization (WHO)

@WHO

Did you know?

4⃣0⃣0⃣ million people have no access to essential health services
2⃣1⃣4⃣ million women of reproductive age in developing countries cannot access modern contraceptive methods
2⃣2⃣ million unsafe #abortions occur each year globally

🔸Every day 🗓️ more than 1⃣ million sexually transmitted infections are acquired

🔸Around the 🌎🌍🌏: the number of new #HIV infections among young people is still unacceptably high

#AIDS2022

Every person, irrespective of #HIV status, should be able to realize their sexual and reproductive health and rights.

📌 bit.ly/3SaLODB

#AIDS2022

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Joseph Cherabie MD, MSc🇱🇧🇺🇸🏳️‍🌈 (He/they)

@cityofhope

A Southern California man appears to be cured of #HIV after undergoing a stem cell transplant to treat leukemia, Dr. Jana Dikter of @cityofhope reported this week at #AIDS2022. @eBARnews
ebar.com/story.php?ch=N…

@UCSF

This risky procedure isn't suitable for most people with HIV, it offers clues for more feasible approaches. "These cures are no longer anecdotal - we now have a real case series," said Dr. Steven Deeks of @UCSF . #AIDS2022

@iasociety

.@iasociety put journalists in a bind by holding press conferences so early. Dikter gave a summary at Wed press briefing & @cityofhope issued a press release, but her actual presentation isn't until Monday. Of course, mainstream media reported it right away after the presser.

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@JncherabieMD

Newly released WHO Consolidated Guidelines on HIV, Hepatitis, and STI prevention, diagnosis, treatment, and care for key populations

who.int/news/item/29-0…

#AIDS2022

Essential health interventions recommended below!

And newly released UNAIDS Report, highlighting HIV acquisition amongst priority populations

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@annieluet

Annie Luetkemeyer (@annieluet) reports doxycycline PEP reduces risk of STIs for gay/bi men & trans women on #PrEP (incidence 32% vs 11%) & #HIV+ (31% vs 12%) — even more so for those who used it consistently. @UCSF #AIDS2022

DoxyPEP led to reductions in #gonorrhea, #chlamydia & #syphilis. Analysis of antibiotic resistance & gut microbiome is underway. #AIDS2022

@cityofhope

City of Hope Patient is older than the few other people previously cured after stem cell transplants & he's been living with #HIV longer, suggesting this approach may be feasible for more people with both HIV & cancer. #AIDS2022 @cityofhope #AIDS 1/
bit.ly/3zDttb6

@TimothyRayBrown

This follows the cures of @TimothyRayBrown, @londonpatient, the New York Patient -- & some count the Dusseldorf Patient -- making this the 4th or 5th such case. @pozmagazine 2/
poz.com/article/patient

Stem cell transplants are too risky to be an option for most people living with #HIV, but these findings provide clues that could help researchers develop more widely applicable approaches for long-term HIV remission. 3/