Discover and read the best of Twitter Threads about #akkermansia

Most recents (3)

🧵 Thread zum Thema #GI #gastrointestinale Probleme im Zuge von #LongCovid

Viele #longcovid (und auch #mecfs) Betroffene berichten von anhaltenden Verdauungsproblemen wie Durchfall - #Diarrhoea nach der Infektion.

Auch ich habe seit 11 Monaten eine gestörte Verdauung …

1/17
6 Monate nach der Infektion wurde es immer schlimmer, unverdaute Substanzen im Stuhl, anhaltender Wasser- und Kräfteentziehender Durchfall.

Ich lies eine #Mikrobiomanalyse einer Stuhlprobe durchführen. (Kosten: 130€)

2/17
Mit folgenden auffälligen Ergebnissen:

1. #leakygut, … heißt mein Darm ist löchrig und Stoffe die eigentlich ausgeschieden in die Toilette gehören, landen leider auch im Blut, woraufhin leider auch das Immunsystem wie zb #Mastzellen reagieren können.

3/17
Read 17 tweets
Have you ever wished to sequence SPECIFIC bacteria but NOT the vast background in #microbiome? Today, we introduce *mEnrich-seq*: #methylation-guided enrichment sequencing of bacterial taxa of interest from microbiome. 4yr project led by @clannabel7! biorxiv.org/content/10.110…🧵1/10
#Metagenomic sequencing throughput is largely consumed by abundant microbes while those with relatively lower abundance cannot be sequenced in a cost-effective manner, due to the highly skewed abundance distribution of diverse bacteria and host DNA. 2/10
Although several methods have been developed (pls see Introduction in preprint) to exclude host DNA and/or the highly abundant microbes, there are still key challenges in achieving high enrichment efficiency and differentiating between bacterial taxa w/ very similar genomes. 3/10
Read 10 tweets
Cross-sectional surveys have generated exciting hypotheses for how our bacteria influence our health and well-being. Next phase in #microbiome research requires that we develop a personalized model of the gut ecosystem and test hypotheses more directly with bacterial isolates.
Here, we unveil the @broadinstitute @OpenBiome Microbiome Library (BIO-ML) a resource of thousands of human gut bacterial isolates paired with whole genome sequences and longitudinal multi-omic data (broadinstitute.org/bio-ml).
Read 10 tweets

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