Discover and read the best of Twitter Threads about #allergists

Most recents (3)

1/ As #Allergists, built upon the recommendations of U.S. regulatory agencies, we can provide clear steps to the medical community on how to safely administer both doses of the #COVID vaccine in individuals with #allergic histories. #AIMedEd…
2/ Neither the #PfizerBioNTech nor #Moderna #COVID19 mRNA vaccines are formulated with any food, drugs, or latex, but both contain the excipient #PEG. However, to date, confirmation that PEG is the cause of reactions to #CovidVaccines is lacking.
3/ Complement-activation-related pseudoallergy, vasovagal reactions (well known cause of hypotension), anxiety symptoms or vocal cord dysfunction can mimic symptoms of severe allergic reactions. Serum #tryptase, complement studies, and #PEG antibodies may be helpful.
Read 6 tweets
1/OK so there *may* be new reports of allergy to #COVID19 vaccines but many other things (e.g., vasovagal syncope) can be misdiagnosed as allergy so we need more clinical details from the UK…
2/ BUT, it is not surprising that allergic reactions might be identified during massive vaccination but not clinical trials because #allergy to vaccines are exceedingly rare (1 per million). In the @US_FDA report, AEs within 30 min for vaccine vs placebo were similar: Image
3/Most vaccine allergies come from the excipients and allergists can do skin testing to the vaccine and its excipients (often facilitating safe and totally unremarkable vaccination). Excipients are often shared for many approved vaccines:…
Read 10 tweets
So much talk this morning about the headlines re:  #Pfizervaccine and #allergicreaction. Let’s not add to the fire. #MedTwitter #AllergyTwitter
#Allergists are losing it... myself included... a long thread... 1/
First, the reports do not give us any details about the reactions.  In allergy practice of the most important things is the history. What were the symptoms, what was the timing, what is the patient’s previous history? Without this, we shouldn’t jump to conclusions. 2/
Second, in the Phase 3 data released by Pfizer there was a report of a “slight imbalance” in potential allergic reactions in the vaccine group when compared to the placebo group at a rate of 0.63% compared to 0.51%… that is VERY VERY SMALL. 3/
Read 14 tweets

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