Discover and read the best of Twitter Threads about #anemiaregion

Most recents (2)

1/14

πŸŽ€β€œDon’t make a change too complicated, just begin.”

πŸ”Š We have a chance to make a β€˜change for good’ in anemia Rx in CKD.

πŸ‘₯Let’s discuss hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs), the probable championsπŸ† of NephMadness 2021. #AnemiaRegion
2/ πŸ“–Hypoxia Inducible Factor (HIF) - Physiology

- Present in all tissues.
- Has O2 regulated πžͺ (3 isoforms) and constitutively expressed 𝛃 subunits.
- HIF-2πžͺ is expressed in the peritubular fibroblasts, mainly involved in the upregulation of EPO gene.
3/

πŸ—οΈβ†“ Hypoxia, HIF πžͺ heterodimerizes with 𝛃 subunit in the nucleus β†’ the complex binds with DNA sequences called hypoxia response elements β†’ Gene activation β†’ ↑ RBC production by ↑ essential protein synthesis linked with iron and EPO pathways. mdpi.com/1422-0067/19/2…
Read 14 tweets
1/12

It has been more than a century tackling Anemia in CKD since its first description by Richard Bright in 1835.

πŸ‘‰ #NephMadness 2021 is featuring strong contenders from the #AnemiaRegion.

πŸ€” Let's find out why Anemia in CKD is an important consideration. #NSMCInternship
2/πŸ“Š What % of patients with CKD stage 4 have anemia based on KDOQI (Hb <13.5 g/dL for men and <12.0 g/dL for women) and WHO (<13.0 g/dL for men & <12.0 g/dL for women)?
3/

😳 Around 60% of the patients with stage 4 CKD not on dialysis have anemia based on KDOQI/WHO.

😟 Anemia contributes to significant morbidity in patients with CKD.

pubmed.ncbi.nlm.nih.gov/18359408/
Read 12 tweets

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