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Here's a question that you might not have considered: how did the dose for #sacubitril/valsartan in #HFrEF get chosen?
Out today is a paper in @JACCJournals led by @RezaMohebiMD that addresses some questions about sac/val dose in HFrEF.
a 🧵
jacc.org/doi/epdf/10.10…
Out today is a paper in @JACCJournals led by @RezaMohebiMD that addresses some questions about sac/val dose in HFrEF.
a 🧵
jacc.org/doi/epdf/10.10…
It's a little known fact that prior to the PH3 PARADIGM trial, a PH2 study in HFrEF was not performed--normally PH2 studies provide target doses for the pivotal outcomes trials.
So how was the dose of sacubitril/valsartan chosen??
So how was the dose of sacubitril/valsartan chosen??
The target dose of 97/103 mg twice daily was selected to achieve serum concentrations of valsartan = to those in Val-HeFT and VALIANT while simultaneously achieving 90% neprilysin inhibition in normal individuals.
Thank you to everyone who responded to our call below.
All signposts to resources/networks/committees will appear in the following Wiley texts (if proposals accepted), see thread 🧵👇🏻
#AdvancedPractice #ACP #ACCP #SCP #CNS #FCP #ANP @HonoraryGeordi_
All signposts to resources/networks/committees will appear in the following Wiley texts (if proposals accepted), see thread 🧵👇🏻
#AdvancedPractice #ACP #ACCP #SCP #CNS #FCP #ANP @HonoraryGeordi_
📕#ACP at a glance - approved, due in print Autumn/Winter 2022
📙#AdvancedPractice Framework (APF) for UK practice - approved, due in print Autumn/Winter 2022
📘 APF for Acute, Emergency & Crit Care - proposal under peer review
#CriticalCare #emergencymedicine #ACCP #ECACP
📙#AdvancedPractice Framework (APF) for UK practice - approved, due in print Autumn/Winter 2022
📘 APF for Acute, Emergency & Crit Care - proposal under peer review
#CriticalCare #emergencymedicine #ACCP #ECACP
📗 APF for #Paediatric & Child Health - proposal in development
📙 APF for MH, LD & Autism - initial expressions of interest (EOIs)
📕 APF for #PrimaryCare - initial EOIs
📘 APF for #Frailty , Rehabilitation & community-based care - (initial EOIs!)
#AdvancedPractice #ACP #AP
📙 APF for MH, LD & Autism - initial expressions of interest (EOIs)
📕 APF for #PrimaryCare - initial EOIs
📘 APF for #Frailty , Rehabilitation & community-based care - (initial EOIs!)
#AdvancedPractice #ACP #AP
What happens to BNP when a person is started on #sacubitrilvalsartan?
#BNP should go up, right?
Thanks to work by @pmyhre in our group, we have some new and interesting data.
A 🧵, read on! 👇
#BNP should go up, right?
Thanks to work by @pmyhre in our group, we have some new and interesting data.
A 🧵, read on! 👇
When the #PARADIGM-HF study was published, one of the things immediately noticed was the increase in BNP that occurred after being started on sacubitril/valsartan.
This is because through effect of sacubitril, neprilysin is inhibited. Why might this lead to an increase in BNP?
This is because through effect of sacubitril, neprilysin is inhibited. Why might this lead to an increase in BNP?
#Neprilysin is a ubiquitous metalloproteinase that assaults BNP (among other targets including ANP and CNP) and cleaves it in numerous places as shown.
Note that in BNP, there are cleavage sites that involve numerous places where immunoassays for measurement of BNP may bind.
Note that in BNP, there are cleavage sites that involve numerous places where immunoassays for measurement of BNP may bind.
PTI Leader Mr #FawadChaudhry revealed to Dr Moeed Pirzada that Mr Ansar Abbasi , Mr Hamid Mir & Mr Orya Maqbool Jan connived with the #Taliban against #Pakistan
Ref : dailymotion.com/video/x2drk99
#TTP #China
#ETIM #AlQaeda #Afghanistan #CPEC #OBOR #DasuDam #FATA #FATF
Ref : dailymotion.com/video/x2drk99
#TTP #China
#ETIM #AlQaeda #Afghanistan #CPEC #OBOR #DasuDam #FATA #FATF
تحریک انصاف کے رہنما #فواد_چوہدری صاحب کیمطابق انصار عباسی ، حامد میر اور اوریا مقبول جان نے پاکستان کیخلاف طالبان کے ساتھ مل کر محاز قائم کیا
dailymotion.com/video/x2drk99
#TTP #China #Taliban #Pakistan
#ETIM #AlQaeda #Afghanistan #CPEC #OBOR #DasuDam #FATA #FATF
dailymotion.com/video/x2drk99
#TTP #China #Taliban #Pakistan
#ETIM #AlQaeda #Afghanistan #CPEC #OBOR #DasuDam #FATA #FATF
PTI Leader Mr #FawadChaudhry says “ death of Most Wanted Terrorist #HakimullahMehsud of #TTP is like a personal loss of #PTI , #PMLN , Mr Imran Khan & Chaudhry Nisar
Ref : dailymotion.com/video/x16qjnk
#China
#ETIM #AlQaeda #Afghanistan #CPEC #OBOR #DasuDam #FATA #FATF #Taliban
Ref : dailymotion.com/video/x16qjnk
#China
#ETIM #AlQaeda #Afghanistan #CPEC #OBOR #DasuDam #FATA #FATF #Taliban
1. Voy a hacer un hilo hoy con mi actuación en el Parlamento desde noviembre de 2018, fecha en la que dejé el Directorio del @bseuruguay, hasta hoy. En este período próximo a terminar, fui diputado suplente en orden preferencial de la Lista 10 del @partidocolorado
@bseuruguay @PartidoColorado 2. En el período mencionado fui Convocado a la Cámara de Representantes en 35 oportunidades. Asistí a todas las convocatorias. No asistí a la del 14 de agosto, porque no fui notificado de la licencia que se pidió el titular.
parlamento.gub.uy/camarasycomisi…
parlamento.gub.uy/camarasycomisi…
@bseuruguay @PartidoColorado 3. Fui convocado en 5 ocasiones a concurrir a Comisiones, participando en 4 oportunidades. A la que no concurrí, fue a la del 14 de agosto, por la misma razón que en el posteo anterior.
#Cantandolaposta
parlamento.gub.uy/camarasycomisi…
#Cantandolaposta
parlamento.gub.uy/camarasycomisi…
