Discover and read the best of Twitter Threads about #antivirals

Most recents (14)

What's going on with #China and #COVID-19?

Model 📈 covid19.healthdata.org
Blog 🗨️ bit.ly/IHME-Episodes
Briefings 📊 healthdata.org/covid/updates

Here's the breakdown: a thread 🧵 The daily reported COVID-19 death rate per 1 million in Chin
What we're expecting in #China:
- Major #omicron epidemic in coming months
- According to our reference scenario, we expect 323,000 total deaths by 4/1/23
- Infections to peak around 4/1, but we expect number of susceptible individuals to sustain transmission months after April
What about #vaccines?

Although there is a high #vaccination rate, there's comparatively low effectiveness of the vaccines used in #China against Omicron & the large gap since vaccination for many individuals means that 80% of the population is susceptible to #Omicron infection.
Read 13 tweets
#FreedomDay would people who now feel they have freedom and #Covid is just a cold, who’ve been on holiday, the pub, concerts, etc., join our #Campaign to getevusheld.uk. @evusheld4theuk is a group of immunosuppressed ppl who don’t respond to Covid vaccine. Because …..
They don’t respond to #pfizer, #AstraZeneca #Moderna or they can’t have the same vaccine as you because drugs they are taking for @bloodcancer_uk @kidneycareuk @ArthritisSoc and many other diseases you haven’t heard of but YOU might get. Nobody expects a life limiting diagnosis
There is a drug they could have which would act like t(e vaccine acts on you. It’s called #Evusheld and made by Astra Zeneca. The Gov rolled out the vaccines in the emergency of Covid and you can have them without any further testing, no matter which #variants come along…
Read 8 tweets
I am a doctor who contracted covid caring for covid patients at work. Failure to provide RPE left me and my colleagues knowingly exposed to deadly airborne pathogen. Previously fit and well, no co-morbidities, I am a shell of my former self. 🧵 @LaylaMoran @AppgCoronavirus 1/10
Diagnoses so far include, encephalitis, central sleep apnoea, myopericarditis, bilateral sensorineural hearing loss, tinnitus, dysautomnia, POTs, PEM/PESE. 14 mths into this illness, I am still housebound. 2/10
After dedicating the last decade of my life to becoming a doctor & placing myself into significant debt, I now face the threat of dismissal. 3/10
Read 10 tweets
Patients have been asking about the new #COVID19 #antivirals.

I looked into the effectiveness of two well-publicised 'game changer' anti-virals, #Paxlovid and #Lagrevio ImageImage
On the Pfizer medication which has widespread coverage in the media - #Paxlovid - well it is unpublished, though the FDA issued an emergency approval. Pfizer website has minimal info.

But is looks like- for HIGH RISK patients only- it reduces the risk
of hospitalisation or death by 3.5% (that is 29 people needed to be treated, so that 1 benefits).

Caveats ++ as unsure on side effects, cost etc. but that is genuinely useful, yet prob not the 'gamechanger' for community care, which #COVIDcelebs would lead us believe.
Read 6 tweets
Daily Bookmarks to GAVNet 12/29/2021 greeneracresvaluenetwork.wordpress.com/2021/12/29/dai…
Someone in my home has COVID. How do we isolate safely? - Clean Air Crew

cleanaircrew.org/someone-in-my-…

#COVID19, #IsolationAtHome, #TransmissionRisk, #HouseholdMembers
Differences Between a Secular and a Religious Upbringing

dailysignal.com/2021/12/14/dif…

#SecularUpbringing, #ReligiousUpbringing, #ValueSystems, #differences
Read 15 tweets
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses. Image
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011 Image
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic. Image
Read 199 tweets
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus. Image
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component. Image
Read 213 tweets
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%. Image
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies. Image
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others Image
Read 236 tweets
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed. Image
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues. Image
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin. Image
Read 235 tweets
@jenbrea Hey! So I'm getting to the point where I could write a long paper about potential overlapping connections b/t #Alzheimer's and #MECFS, but I'll summarize a few top trends in this thread! First, I brainstormed often on topic with the late Rob Moir
@jenbrea 2/ Rob’s research (done w/ Rudy Tanzi + Will Eimer at Harvard) forms the core of a potential ongoing paradigm shift in Alzheimer’s - namely that #amyloid beta may be an antimicrobial peptide that forms in response to pathogens in #brain tissue: pubmed.ncbi.nlm.nih.gov/30001512/
@jenbrea 3/ To better understand that research, read this #interview I did with Rob before he passed away last year from glioblastoma. Key to ME/CFS is his work indicates that amyloid may form in response to herpesviruses like HSV1 in the Alzheimer’s brain: microbeminded.com/2017/12/18/int…
Read 14 tweets
As the #COVID19 #outbreak evolves, comparisons have been made with #influenza. Both cause respiratory disease but there are important differences between #SARSCoV2 #virus causing COVID-19 & the influenza virus causing the #flu [from WHO COVID situation report 06.03.2020] #scicomm
Similarity #1. Both #COVID19 & the #flu have a similar disease presentation. Both cause respiratory disease, which presents as a wide range of illness from asymptomatic or mild through to severe disease and even death.
Similarity #2. Both #SARSCoV2 & #influenza viruses are transmitted by contact, droplets & fomites so same #publichealth measures (hand hygiene, good respiratory etiquette (coughing into elbow / into a tissue, immediately disposing of the tissue) are important to prevent infection
Read 13 tweets
#Event201 begins. Check it out online to participate virtually! centerforhealthsecurity.org/event201/ #pandemic #biosecurity
Global leaders in business and government have convened to address the pandemic situation. @T_Inglesby from @JHSPH_CHS Moderates. See the #Event201 website for details on the participants.
Global distribution of cases and deaths from #Event201
Read 45 tweets
Incredibly important hypothesis piece published today 👉 “Proposed here is a theory that #microorganisms from within the #brain and elsewhere in the body contribute to the long-term #neurological deterioration characteristic of traumatic brain injury”: sciencedirect.com/science/articl…
From paper 👉 1. “First, since the normal human #brain is not sterile, but is host to a variety of microorganisms, blows to the #skull may dislodge them from their accustomed local environments, in which they have been living in quiet equilibrium with neighboring #brain cells”
2. “2nd, upon impact commensal #microbes already resident on surfaces of the nose, mouth + eyes, and potentially harmful organisms from the environment, may gain access to the #brain through the distal ends of the olfactory + optic #nerves or even a disrupted blood-brain barrier”
Read 6 tweets

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