Discover and read the best of Twitter Threads about #apob
Most recents (11)
1/🧵 If Plaque #ApoB-48 > #ApoB-100
Quite a rabbit hole so far...
First, let me say that data on this has been a bit limited. But *IF* we do ultimately confirm there are more ApoB-48 (B48) than ApoB-100 (B100) in ASCVD plaque, it would be a very big deal.
Let's unpack...
Quite a rabbit hole so far...
First, let me say that data on this has been a bit limited. But *IF* we do ultimately confirm there are more ApoB-48 (B48) than ApoB-100 (B100) in ASCVD plaque, it would be a very big deal.
Let's unpack...
2/ First, thanks to @TuckerGoodrich for pinging me on these pubs and pressing the discussion.
But also credit to @CaloriesProper on tweeting this a couple years ago (I missed it then)
To understand why this would be so important if true, some review...
But also credit to @CaloriesProper on tweeting this a couple years ago (I missed it then)
To understand why this would be so important if true, some review...
3/ B48 and B100s are the major proteins on chylomicrons (CMs) and VLDLs, respectively.
CMs mostly carry lipids from the small intestine to the bloodstream (lipids consumed), VLDL mostly carry lipids from storage; predominantly from adipose stores.
See full linages here 👇
CMs mostly carry lipids from the small intestine to the bloodstream (lipids consumed), VLDL mostly carry lipids from storage; predominantly from adipose stores.
See full linages here 👇
1/🧵 I'm definitely a fan of both @DominicDAgosti2 and @DrRagnar (obviously), so I was excited to see them chatting about #lipids, #LMHRs, and Dom's consideration of increasing carbs to lower his #ApoB
If no one minds, I'd like to add some thoughts...
If no one minds, I'd like to add some thoughts...
2/ First -- I'm extremely excited to share @DominicDAgosti2 may be the most notable N=1 I've waited for regarding #ResistanceTraining change & #LDL/#ApoB in a #ketogenetic context
Those who've followed me for a while know exactly what I'm talking about...
Those who've followed me for a while know exactly what I'm talking about...
3/ When chatting with Dom in SD last year for dinner, he mentioned focusing less on maintaining such a sizable muscle mass as he typically does, and I predicted he'd likely see his LDL/ApoB as considerably higher with this change if still #keto. This podcast appears to confirm...
1/🚨New Episode🚨
The Lipid Panel Reimagined: #MindtheGap Segment
How do you interpret the #lipidpanel to help inform patients' risk for #cardiovascular disease? Do you use #ApoB? 🧐
🎧: link.chtbl.com/Lipids
Sponsor: go.amboss.com/CoreIM-E8
The Lipid Panel Reimagined: #MindtheGap Segment
How do you interpret the #lipidpanel to help inform patients' risk for #cardiovascular disease? Do you use #ApoB? 🧐
🎧: link.chtbl.com/Lipids
Sponsor: go.amboss.com/CoreIM-E8
2/ Unfortunately, our patient is stuck in "bumper-to-bumper" #cholesterol traffic 🚗!
See traffic analogy to understand why ApoB can give us information that LDL-C may not:
#Mindblown! 🤯
See traffic analogy to understand why ApoB can give us information that LDL-C may not:
#Mindblown! 🤯
3/ Overall, LOWER ⬇️ is better for both #LDL-C and #ApoB in terms of reducing #CV disease risk!
But #discordance between LDL-C vs. ApoB is actually quite common!
Take a look at the orange line to see how ApoB confers a higher CVD risk over time 👇
But #discordance between LDL-C vs. ApoB is actually quite common!
Take a look at the orange line to see how ApoB confers a higher CVD risk over time 👇
🧵 Dec 9th anniversary thread
On this day in 2015 I received a lab result that would alter the course of my life.
Just two weeks earlier I had gotten my very first bloodwork after half a year on #keto that showed my total and #LDL #Cholesterol had nearly doubled (!)… /1
On this day in 2015 I received a lab result that would alter the course of my life.
Just two weeks earlier I had gotten my very first bloodwork after half a year on #keto that showed my total and #LDL #Cholesterol had nearly doubled (!)… /1
2/ With that first test I was overcome with shock and curiosity — much more former than the latter.
I wanted to get a repeat test to confirm this wasn’t a lab error.
I wasn’t ready to give up #keto, but I was miserable enough that I ate considerably less.
I wanted to get a repeat test to confirm this wasn’t a lab error.
I wasn’t ready to give up #keto, but I was miserable enough that I ate considerably less.
3/ At the same time I learned as much as I could about Lipidology - which focuses on how the body moves lipids (like cholesterol) in the blood.
And to my surprise, this system is already very familiar to me as a software engineer given it is a distributed object network.
And to my surprise, this system is already very familiar to me as a software engineer given it is a distributed object network.
🧵 New paper on comparing advanced lipid testing (NMR) with body fat (adiposity) - ht @nicknorwitz
High adiposity associates with:
- ⬆️ #ApoB & #LDL-C
- ⬆️ #triglycerides
- ⬆️ levels of all fatty acids
How does this relate to #LEM? Let's unpack... /1
nature.com/articles/s4385…
High adiposity associates with:
- ⬆️ #ApoB & #LDL-C
- ⬆️ #triglycerides
- ⬆️ levels of all fatty acids
How does this relate to #LEM? Let's unpack... /1
nature.com/articles/s4385…
2/ "Adiposity-related hypertriglyceridemia is mainly driven by increased numbers of triglyceride-rich VLDLs (which carry the largest proportion of triglycerides in blood). Concurrently, the cholesterol in these lipoproteins also seem to be higher at higher adiposity levels."
3/ And these next sentences are key -- take special note of the underlined text...
1/ I'd love to take an opportunity to expand on this important topic, and if I may, suggest something important to watch for with some newly emerging data.
To @MichaelMindrum point, I too believe the #ApoB will demonstrate higher association with #ASCVD than #LDL #Cholesterol..
To @MichaelMindrum point, I too believe the #ApoB will demonstrate higher association with #ASCVD than #LDL #Cholesterol..
2/ But to be sure, ApoB can be best represented as:
(1) Non-LDL ApoB lipoproteins
- and -
(2) LDL ApoB lipoproteins
The first category is predominantly chylomicrons, VLDL, and IDL -- which associate very highly with ASCVD.
(1) Non-LDL ApoB lipoproteins
- and -
(2) LDL ApoB lipoproteins
The first category is predominantly chylomicrons, VLDL, and IDL -- which associate very highly with ASCVD.
3/ You can think of category (1) as "Triglyceride Rich Lipoproteins" (TRL, aka "remnants") and category (2) as "Triglyceride Poor Lipoproteins" (TPL)
The population of #LMHRs have extremely high levels of ApoB. But this pattern is a mix of very *low* TRL and very high TPL.
The population of #LMHRs have extremely high levels of ApoB. But this pattern is a mix of very *low* TRL and very high TPL.
1/6 Yes -- this article is over 3 years old now and I then presented on Remnant Cholesterol (RC) at LC Denver earlier that year.
In rereading this article, there are a few things I'd update -- but the general focus on systemic outcome relevance still holds...
In rereading this article, there are a few things I'd update -- but the general focus on systemic outcome relevance still holds...
2/6 A more updated article on this, along with further thoughts, can be found here: cholesterolcode.com/thoughts-regar…
3/6 If you read nothing else, check out this section from the article, and why I'm so vocal about *not* looking only at #ApoB (which lumps non-LDL and LDL) together.
Again -- and with emphasis -- this is part of the larger hypothesis. But all the more reason to research it...
Again -- and with emphasis -- this is part of the larger hypothesis. But all the more reason to research it...
1/ This new MR study by @mendel_random, @mvholmes, et al makes use of UK Biobank data and determines #ApoB increases risk of #AllCauseMortality, and even #T2Diabetes
This is actually relevant timing as we are rapidly approaching the #LMHRstudy. sciencedirect.com/science/articl…
This is actually relevant timing as we are rapidly approaching the #LMHRstudy. sciencedirect.com/science/articl…
2/ If you didn't already know, "Lean Mass Hyper-responders" (#LMHRs) would be considered hypercholesterolemic, with this resulting from being very low carb (typically #keto), and are often lean and/or athletic.
(You can read more on this phenotype at CholesterolCode.com/lmhr)
(You can read more on this phenotype at CholesterolCode.com/lmhr)
3/ Setting aside why this population exhibits this (see #LipidEnergyModel for more), the most important question is whether they are at risk.
This MR study builds on the existing conventional expectation that they are, and no less in a dose-dependent manner...
This MR study builds on the existing conventional expectation that they are, and no less in a dose-dependent manner...
1/ For a very layperson-friendly video on conventional view of #LDL / #HDL #Cholesterol, and #ApoB, I highly recommend this one from @NutritionMadeS3
It's very visual and IMO fairly true to the more specific position of mainstream lipidology...
It's very visual and IMO fairly true to the more specific position of mainstream lipidology...
2/ Love his opening: "why is this topic so confusing? well, for starters scientists are horrible at coming up with names...there's LDL...and LDL cholesterol and they're different things....but a lot of people call them both LDL....and then there's HDL, VLDL..." (trails off)
3/ He's 100% right. It's why it's so hard to convert this for the lay audience. Lipidology could use a terminology upgrade.
For example, how did "Chylomicrons" manage to get a special exception to the "-DL" acronym party? (Only fellow lipophiles will get that joke... 😐)
For example, how did "Chylomicrons" manage to get a special exception to the "-DL" acronym party? (Only fellow lipophiles will get that joke... 😐)
1/ My presentation to @stanford on the Lipid Energy Model is now up at my channel.
It was a great honor to be invited and discuss my research, experiments, and this hypothesis in depth.
Lots of discussion on #LDL #HDL #Cholesterol #ApoB and #LipidTriad
It was a great honor to be invited and discuss my research, experiments, and this hypothesis in depth.
Lots of discussion on #LDL #HDL #Cholesterol #ApoB and #LipidTriad
2/ For many of you who have followed my work for a while, this will feel like review. But this presentation challenged me to tie everything together as best I could for a non-#keto/#lchf audience at a university level. Given the feedback /retention, it appears to have gone well..
3/ Of course, there's quite a lot that it *not* covered, and indeed I wanted to squeeze a bit more into it. Sometimes I wish I could summarize the energy delivery throughput and cross my fingers everyone at a certain level will get it. But that's been the biggest challenge...
1/ #ListenThread -
My guest appearance on #SigmaNutritionRadio just dropped where I have a very friendly #debate with @NutritionDanny and Alan Flanagan on #LDL #Cholesterol, #ApoB, #Atherosclerosis, #AllCauseMortality & much, much more!
sigmanutrition.com/episode321/
My guest appearance on #SigmaNutritionRadio just dropped where I have a very friendly #debate with @NutritionDanny and Alan Flanagan on #LDL #Cholesterol, #ApoB, #Atherosclerosis, #AllCauseMortality & much, much more!
sigmanutrition.com/episode321/
2/ I did this podcast semi-sleep deprived and between interviews for #TheCCDoc. But I know my main hopes going in were to emphasize:
(1) Why I favor the "Lipid profile-centric" model over the "Lipoprotein-centric" model.
(2) How this is relevant to "the triad" ⬆️LDL⬆️HDL⬇️TG
(1) Why I favor the "Lipid profile-centric" model over the "Lipoprotein-centric" model.
(2) How this is relevant to "the triad" ⬆️LDL⬆️HDL⬇️TG
3/
(3) Why this triad is of particular interest to all of us as it relates to not just cardiovascular disease, but in particular -- all cause mortality (ACM)
I honestly couldn't remember how well I did in getting these core points across, thus relistening now...
(3) Why this triad is of particular interest to all of us as it relates to not just cardiovascular disease, but in particular -- all cause mortality (ACM)
I honestly couldn't remember how well I did in getting these core points across, thus relistening now...
