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SARS-CoV-2 contains a novel nuclearization sequence PRRARSV in the spike protein. This is equivalent to the Simian Immunodeficiency Virus SV 40 TAg. Both the spike protein itself and mRNA are found to translocate to the nucleus.
ncbi.nlm.nih.gov/pmc/articles/P…
ncbi.nlm.nih.gov/pmc/articles/P…
Here is general information SV 40 TAg from Wikipedia. The protein is ideal for studying nuclearization signals.
en.wikipedia.org/wiki/SV40_larg…
en.wikipedia.org/wiki/SV40_larg…
The spike is imported into the nucleus with importin a.
sciencedirect.com/science/articl…
sciencedirect.com/science/articl…
